Intergeneration perception toward happiness in elderly life

According to the latest statistics released by the Census and Statistics Department, the Hong Kong population aged 65 and over was 829,300 at the end of 2004. The number of persons aged 65 or older is projected to increase by 17.9% to 978,000, representing 13.2% of population in 2013. This increase in the number and proportion of elderly will intensify the challenges of ageing, which will put further pressure on the government and the society at large. In response to Hong Kong\u27s rapid aging population and in line with the concept of active and successful ageing, the question of how to assist the elderly to achieve a happy elder life has become a very important issue. According to World Health Organization (WHO), healthy” is defined as having good physical, psychological, and social status. Therefore, having a happy elder life means not only having good physical health, but also good psychological state and social status. In the past, studies on understanding the happiness of the elderly were scarce in Hong Kong. The survey on “How to lead a Happy Elder Life” conducted by Hong Kong Christian Service and Elderly Council (2001) was one of the first local study on elderly’s perception about happiness. Similar to other studies overseas (Kehn 1995; Ikels 1994), it was found that “good health status”, “good social relationship”, “stable financial situation”, and “good living arrangement” were the key factors affecting the well-being of the elderly. In addition, some scholars found that the involvement and participation across the generations is also an important element that determines well-being and happiness among the elderly (Hareven 1996). According to Sellars (1998), the collaboration between teenagers and elderly in daily life or school life would not only improve the relationship and understanding among two generations, but would also improve the self-worth of the elderly giving rise to a more fulfilling elder life. In addition, it was found that the quality of care provided by mid-aged adults (such as care givers for the elderly) was another factor affecting the life satisfaction level of the elderly (Hareven and Adams 1996; Hogan, Eggebeen and Snaith 1996). Based on the findings of these studies, it is believed that having a happy elder life requires the mutual effort of and contribution from different generations. In order to assist the elderly people to lead a happy elder life, the Elderly Commission has been promoting the concept of “Healthy Ageing” in Hong Kong since 2001. The aim of the campaign of Healthy Aging was to create a sustained healthy living environment and to allow the citizens to enjoy their elder life autonomously (Department of Health and Elderly Commission 2001). In response to this campaign, Hong Kong Christian Service combine the concepts of “Healthy Aging” and “Happy Elder Life” 3 to conduct an elderly survey on “how to lead a happy elder life” in 2001 (Hong Kong Christian Service 2001). A second study was conducted four years later. The main objectives of this survey remain the same, they are to find out the happiness index in 2005 compared with the 2001 survey and to understand how people of different age groups perceive the question of “How to lead a Happy Elder Life”. The findings of the study serve as useful inputs for promoting mutual understanding, care, and love among the different generations in Hong Kong

The Query Cube: A Framework for Assessing User Productivity with Database Information Retrieval

Three key factors that affect user productivity on database information retrieval are representation realism, expressive ease, and task complexity. Representation realism is the level of abstraction used in formulating queries. Expressive ease is the syntactic flexibility of a query language. Task complexity is the level of difficulty of queries. These factors formed a three dimensional query cube. A laboratory experiment was conducted to evaluate user productivity on database information retrieval corresponding to different vertices of the query cube. The results show that the query cube is a viable framework for assessing user productivity, both on effectiveness and efficiency perspective

Mitigating information frictions in trade:Evidence from export credit guarantees

Information frictions make foreign trade risky. In particular, the risk of buyer default deters firms from selling abroad. To address this issue, many countries offer export credit guarantees to provide insurance to exporters. In this paper, we investigate the causal effects of guarantees by exploiting a quasi-natural experiment in Sweden and rich register data on guarantees, firms and trade. Estimates from a fuzzy regression discontinuity design show large positive effects on the probability of exporting and the value of exports to the destination for which the guarantees are issued. These results are robust to an alternative approach using a difference-in-differences matching estimator. Further findings suggest that guarantees impact firms heterogeneously and play an important role in resolving buyer default risk and easing liquidity constraints. Larger impacts are observed in non-OECD countries, on smaller, liquidity constrained exporters and for firms selling products that face a relatively high cost of buyer default.</p

A Method of Drusen Measurement Based on the Geometry of Fundus Reflectance

BACKGROUND: The hallmarks of age-related macular degeneration, the leading cause of blindness in the developed world, are the subretinal deposits known as drusen. Drusen identification and measurement play a key role in clinical studies of this disease. Current manual methods of drusen measurement are laborious and subjective. Our purpose was to expedite clinical research with an accurate, reliable digital method. METHODS: An interactive semi-automated procedure was developed to level the macular background reflectance for the purpose of morphometric analysis of drusen. 12 color fundus photographs of patients with age-related macular degeneration and drusen were analyzed. After digitizing the photographs, the underlying background pattern in the green channel was leveled by an algorithm based on the elliptically concentric geometry of the reflectance in the normal macula: the gray scale values of all structures within defined elliptical boundaries were raised sequentially until a uniform background was obtained. Segmentation of drusen and area measurements in the central and middle subfields (1000 μm and 3000 μm diameters) were performed by uniform thresholds. Two observers using this interactive semi-automated software measured each image digitally. The mean digital measurements were compared to independent stereo fundus gradings by two expert graders (stereo Grader 1 estimated the drusen percentage in each of the 24 regions as falling into one of four standard broad ranges; stereo Grader 2 estimated drusen percentages in 1% to 5% intervals). RESULTS: The mean digital area measurements had a median standard deviation of 1.9%. The mean digital area measurements agreed with stereo Grader 1 in 22/24 cases. The 95% limits of agreement between the mean digital area measurements and the more precise stereo gradings of Grader 2 were -6.4 % to +6.8 % in the central subfield and -6.0 % to +4.5 % in the middle subfield. The mean absolute differences between the digital and stereo gradings 2 were 2.8 +/- 3.4% in the central subfield and 2.2 +/- 2.7% in the middle subfield. CONCLUSIONS: Semi-automated, supervised drusen measurements may be done reproducibly and accurately with adaptations of commercial software. This technique for macular image analysis has potential for use in clinical research

Determining seropositivity-A review of approaches to define population seroprevalence when using multiplex bead assays to assess burden of tropical diseases.

BACKGROUND: Serological surveys with multiplex bead assays can be used to assess seroprevalence to multiple pathogens simultaneously. However, multiple methods have been used to generate cut-off values for seropositivity and these may lead to inconsistent interpretation of results. A literature review was conducted to describe the methods used to determine cut-off values for data generated by multiplex bead assays. METHODOLOGY/PRINCIPAL FINDINGS: A search was conducted in PubMed that included articles published from January 2010 to January 2020, and 308 relevant articles were identified that included the terms "serology", "cut-offs", and "multiplex bead assays". After application of exclusion of articles not relevant to neglected tropical diseases (NTD), vaccine preventable diseases (VPD), or malaria, 55 articles were examined based on their relevance to NTD or VPD. The most frequently applied approaches to determine seropositivity included the use of presumed unexposed populations, mixture models, receiver operating curves (ROC), and international standards. Other methods included the use of quantiles, pre-exposed endemic cohorts, and visual inflection points. CONCLUSIONS/SIGNIFICANCE: For disease control programmes, seropositivity is a practical and easily interpretable health metric but determining appropriate cut-offs for positivity can be challenging. Considerations for optimal cut-off approaches should include factors such as methods recommended by previous research, transmission dynamics, and the immunological backgrounds of the population. In the absence of international standards for estimating seropositivity in a population, the use of consistent methods that align with individual disease epidemiological data will improve comparability between settings and enable the assessment of changes over time

On the effectiveness of natural hedging for insurance companies and pension plans

Natural hedging is one possible method to reduce longevity risk exposure for an annuity provider or a pension plan. In this paper, we provide an assessment of the effectiveness of natural hedging between annuity and life products, using the correlated Poisson Lee–Carter model, Poisson common factor model, product-ratio model, and historical simulation. Our analysis is based on the mortality experience of UK assured lives, pensioners, and annuitants, and the national population of England and Wales. We consider a range of different scenarios, and find that the level of risk reduction is significant in general, with an average of around 60%. These results have important implications for those insurers, reinsurers, and pension plan sponsors who are seeking ways to hedge their unwanted risk exposures

Repurposing hyperpolarization-activated cyclic nucleotide-gated channels as a novel therapy for breast cancer.

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are members of the voltage-gated cation channel family known to be expressed in the heart and central nervous system. Ivabradine, a small molecule HCN channel-blocker, is FDA-approved for clinical use as a heart rate-reducing agent. We found that HCN2 and HCN3 are overexpressed in breast cancer cells compared with normal breast epithelia, and the high expression of HCN2 and HCN3 is associated with poorer survival in breast cancer patients. Inhibition of HCN by Ivabradine or by RNAi, aborted breast cancer cell proliferation in vitro and suppressed tumour growth in patient-derived tumour xenograft models established from triple-negative breast cancer (TNBC) tissues, with no evident side-effects on the mice. Transcriptome-wide analysis showed enrichment for cholesterol metabolism and biosynthesis as well as lipid metabolism pathways associated with ER-stress following Ivabradine treatment. Mechanistic studies confirmed that HCN inhibition leads to ER-stress, in part due to disturbed Ca2+ homeostasis, which subsequently triggered the apoptosis cascade. More importantly, we investigated the synergistic effect of Ivabradine and paclitaxel on TNBC and confirmed that both drugs acted synergistically in vitro through ER-stress to amplify signals for caspase activation. Combination therapy could suppress tumour growth of xenografts at much lower doses for both drugs. In summary, our study identified a new molecular target with potential for being developed into targeted therapy, providing scientific grounds for initiating clinical trials for a new treatment regimen of combining HCN inhibition with chemotherapy