5 research outputs found
Prevention of respiratory tract infections with bacterial lysate OM-85 bronchomunal in children and adults: a state of the art
- Author
- A Capetti
- A Papi
- A Rozy
- A Singanayagam
- B Cvoriscec
- B Orcel
- BE Del-Rio-Navarro
- BE Del-Rio-Navarro
- BE Del-Rio-Navarro
- BE Del-RĂo-Navarro
- BG Williams
- C Steurer-Stey
- CH Razi
- EW Russi
- H Tang
- J Duchow
- J Li
- J Mauel
- JM Puigdollers
- JP Collet
- JP Collet
- JSM Li
- JV Jara-PĂ©rez
- K Crothers
- KR Smith
- M Decramer
- M Huber
- M Kamper-JĂžrgensen
- M Lusuardi
- M SolĂšr
- M Weinberger
- M Weinberger
- MA Alyanakian
- MD Gutiérrez-Tarango
- MD Sprenkle
- MJ MÀkelÀ
- NE Karaca
- O Zaniolo
- PG Holt
- S MiceliSopo
- S Navarro
- UB Schaad
- UB Schaad
- W Oddy
- WG Bessler
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A randomized, placebo-controlled, double-blinded, single-centre, phase IV trial to assess the efficacy and safety of OM-85 in children suffering from recurrent respiratory tract infections
- Author
- A Versporten
- Alberto Argentiero
- BE Del-Rio-Navarro
- CH Razi
- Claudia Tagliabue
- GA Rossi
- Ilaria Coro
- J Cherry
- J Yin
- JA Bielicki
- JV Jara-PĂ©rez
- L Toivonen
- LJ Shallcross
- M de Martino
- N Principi
- N Principi
- N Principi
- Nicola Principi
- PAB Wark
- S Esposito
- S Esposito
- S Esposito
- S Esposito
- S Esposito
- Samantha Bosis
- SC Kearney
- Sonia Bianchini
- Susanna Esposito
- UB Schaad
- UB Schaad
- UB Schaad
- WG Bessler
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Recommended from our members
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19
- Author
- Abdelrazik M
- Abedalthagafi M
- Abel L
- Abel L
- Abellan J
- Abernathy C
- Abraheem A
- Acklery A
- Acosta-Isaac R
- Adam R
- Adams C
- Adams K
- Adams N
- Adanini O
- Afolabi D
- Agasou A
- Agravante K
- Agravante K
- Agrawal S
- Aguado JM
- Aguilar C
- Aguilar PM
- Aguilera-Albesa S
- Ahmad N
- Ahmadhaider N
- Ahmed A
- Ahmed C
- Aitkin E
- Akeroyd L
- Akhtar MN
- Akinkugbe O
- Al-Moasseb H
- Alasdair F
- Alba J
- Albu S
- AlcalĂĄ-Gallardo KAM
- Alcoba-Florez J
- Aldridge J
- Alex B
- Alexander P
- Alfonso J
- Algarin-Lara HR
- Ali A
- Ali HH
- Ali IAM
- Ali S
- Allan A
- Allan E
- Allan J
- Alldis Z
- Allen L
- Allen M
- Allen S
- Allibone S
- Allison KS
- Ally SM
- Almadana V
- Almaden-Boyle C
- Almeida J
- Almoguera B
- Alonso MR
- Altabaibeh A
- Alvarez N
- Alvaro A
- Alves MDM
- Amamio M
- Amamio M
- Amin V
- Anastasescu E
- Anderson J
- Anderson M
- Anderson P
- Anderson S
- Anderson S
- Anderson T
- Andreou P
- Andreu-Bernabeu Ă
- Andrew A
- Andrew B
- Andrew G
- Andrews J
- Andrikopoulos P
- Antcliffe D
- Antoine P
- Antonijoan MR
- Antony S
- Anumakonda V
- Anwer M
- Apetri E
- Aquino M
- Arana-Arri E
- Aranda C
- Arango C
- Araque C
- Araujo IMT
- Araujo NK
- Aravindan L
- Arbane G
- Arcanjo AC
- Archer K
- Arden T
- Arias SS
- Arif S
- Armistead J
- Armstrong D
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- Bafitis V
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- Publication venue
- Springer Nature
- Publication date
- 17/05/2023
- Field of study
Data availability: Downloadable summary data are available through the GenOMICC data site (https://genomicc.org/data). Summary statistics are available, but without the 23andMe summary statistics, except for the 10,000 most significant hits, for which full summary statistics are available. The full GWAS summary statistics for the 23andMe discovery dataset will be made available through 23andMe to qualified researchers under an agreement with 23andMe that protects the privacy of the 23andMe participants. For further information and to apply for access to the data, see the 23andMe website (https://research.23andMe.com/dataset-access/). All individual-level genotype and whole-genome sequencing data (for both academic and commercial uses) can be accessed through the UKRI/HDR UK Outbreak Data Analysis Platform (https://odap.ac.uk). A restricted dataset for a subset of GenOMICC participants is also available through the Genomics England data service. Monocyte RNA-seq data are available under the title âMonocyte gene expression dataâ within the Oxford University Research Archives (https://doi.org/10.5287/ora-ko7q2nq66). Sequencing data will be made freely available to organizations and researchers to conduct research in accordance with the UK Policy Framework for Health and Social Care Research through a data access agreement. Sequencing data have been deposited at the European GenomeâPhenome Archive (EGA), which is hosted by the EBI and the CRG, under accession number EGAS00001007111.Extended data figures and tables are available online at https://www.nature.com/articles/s41586-023-06034-3#Sec21 .Supplementary information is available online at https://www.nature.com/articles/s41586-023-06034-3#Sec22 .Code availability:
Code to calculate the imputation of P values on the basis of SNPs in linkage disequilibrium is available at GitHub (https://github.com/baillielab/GenOMICC_GWAS).Acknowledgements: We thank the members of the Banco Nacional de ADN and the GRA@CE cohort group; and the research participants and employees of 23andMe for making this work possible. A full list of contributors who have provided data that were collated in the HGI project, including previous iterations, is available online (https://www.covid19hg.org/acknowledgements).Change history: 11 July 2023: A Correction to this paper has been published at: https://doi.org/10.1038/s41586-023-06383-z. -- In the version of this article initially published, the name of Ana Margarita BaldiĂłn-Elorza, of the SCOURGE Consortium, appeared incorrectly (as Ana MarĂa Baldion) and has now been amended in the HTML and PDF versions of the article.Copyright © The Author(s) 2023, Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown1 to be highly efficient for discovery of genetic associations2. Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory therapies with strong beneficial effects in this group3. Here we analyse 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a strong focus on severe and critical disease: ISARIC4C (676 cases) and the SCOURGE consortium (5,934 cases). To put these results in the context of existing work, we conduct a meta-analysis of the new GenOMICC genome-wide association study (GWAS) results with previously published data. We find 49 genome-wide significant associations, of which 16 have not been reported previously. To investigate the therapeutic implications of these findings, we infer the structural consequences of protein-coding variants, and combine our GWAS results with gene expression data using a monocyte transcriptome-wide association study (TWAS) model, as well as gene and protein expression using Mendelian randomization. We identify potentially druggable targets in multiple systems, including inflammatory signalling (JAK1), monocyteâmacrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).GenOMICC was funded by Sepsis Research (the Fiona Elizabeth Agnew Trust), the Intensive Care Society, a Wellcome Trust Senior Research Fellowship (to J.K.B., 223164/Z/21/Z), the Department of Health and Social Care (DHSC), Illumina, LifeArc, the Medical Research Council, UKRI, a BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070 and BBS/E/D/30002275) and UKRI grants MC_PC_20004, MC_PC_19025, MC_PC_1905 and MRNO2995X/1. A.D.B. acknowledges funding from the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z), the Edinburgh Clinical Academic Track (ECAT) programme. This research is supported in part by the Data and Connectivity National Core Study, led by Health Data Research UK in partnership with the Office for National Statistics and funded by UK Research and Innovation (grant MC_PC_20029). Laboratory work was funded by a Wellcome Intermediate Clinical Fellowship to B.F. (201488/Z/16/Z). We acknowledge the staff at NHS Digital, Public Health England and the Intensive Care National Audit and Research Centre who provided clinical data on the participants; and the National Institute for Healthcare Research Clinical Research Network (NIHR CRN) and the Chief Scientistâs Office (Scotland), who facilitate recruitment into research studies in NHS hospitals, and to the global ISARIC and InFACT consortia. GenOMICC genotype controls were obtained using UK Biobank Resource under project 788 funded by Roslin Institute Strategic Programme Grants from the BBSRC (BBS/E/D/10002070 and BBS/E/D/30002275) and Health Data Research UK (HDR-9004 and HDR-9003). UK Biobank data were used in the GSMR analyses presented here under project 66982. The UK Biobank was established by the Wellcome Trust medical charity, Medical Research Council, Department of Health, Scottish Government and the Northwest Regional Development Agency. It has also had funding from the Welsh Assembly Government, British Heart Foundation and Diabetes UK. The work of L.K. was supported by an RCUK Innovation Fellowship from the National Productivity Investment Fund (MR/R026408/1). J.Y. is supported by the Westlake Education Foundation. SCOURGE is funded by the Instituto de Salud Carlos III (COV20_00622 to A.C., PI20/00876 to C.F.), European Union (ERDF) âA way of making Europeâ, FundaciĂłn Amancio Ortega, Banco de Santander (to A.C.), Cabildo Insular de Tenerife (CGIEU0000219140 âApuestas cientĂficas del ITER para colaborar en la lucha contra la COVID-19â to C.F.) and FundaciĂłn Canaria Instituto de InvestigaciĂłn Sanitaria de Canarias (PIFIISC20/57 to C.F.). We also acknowledge the contribution of the Centro National de Genotipado (CEGEN) and Centro de SupercomputaciĂłn de Galicia (CESGA) for funding this project by providing supercomputing infrastructures. A.D.L. is a recipient of fellowships from the National Council for Scientific and Technological Development (CNPq)-Brazil (309173/2019-1 and 201527/2020-0)
Elective Cancer Surgery in COVID-19âFree Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study
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- on behalf of the COVIDSurg Collaborative
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- Zouzoulas D
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- Ăngelo M
- ĂlgĂ„ A
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- Ăolak E
- Ăfner D
- Ăhlberger L
- ĂÄĂŒcĂŒ H
- ĂberrĂŒck L
- Äoza I
- Ć imko K
- Ć ÄepanoviÄ V
- ĆœateckĂœ J
- ĐĐ°ĐŒĐ°Đ»ĐŸĐČ Đ
- Publication venue
- American Society of Clinical Oncology
- Publication date
- 01/01/2021
- Field of study
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
- Author
- Aawsaj Y
- Abadia M
- AbadâGurumeta A
- AbadâMotos A
- Abassy J
- Abate E
- Abbasov A
- Abbott D
- Abbott Tom EF
- Abdalla M
- Abdeldayem H
- Abdelkabir M
- Abdelkader Salama I
- Abdelkarim M
- Abdelsamed A
- Abdulfattah F
- Abdulwahed E
- AbdurâRahman LO
- Abel MK
- Abelevich A
- Abiyere H
- Aboelkassem Ibrahim A
- Aboharp Hasan Z
- Abou Chaar MK
- Abreu da Silva A
- Abubakar A
- Abukhalaf SA
- Abukhalaf Sadi
- Acebes GarcĂa F
- Achalandabaso Boira M
- Acher A
- Acosta MĂ©rida MA
- Acrich E
- Adam Essa Adam ME
- Adamina M
- Adamina Michel
- Adamina Michel
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Aderombi A
- Adeyeye A
- Adeyeye A
- Adi H
- Adiamah A
- Adisa Adewale
- Afzal MF
- Agapov M
- Agarwal Arnav
- Aggarwal M
- Aghayeva A
- Agilinko J
- Agnes A
- Agostini C
- Agrawal A
- Agrawal N
- Agresta F
- Aguado LĂłpez H
- Aguiar JĂșnior S
- Aguilar Gonzalez M
- Ahmed A
- Ahmed A
- Ahmed K
- Ahmed ME
- Ahmed Z
- Ahmeidat A
- Ahn JH
- Aiken T
- Aimé A
- Akalin M
- Akaydin E
- Akbas A
- Akhtar MA
- Akhtar N
- Akhter Rahman MM
- Akin E
- Akkulak Murat
- Akrivou D
- Al Abdallah M
- Al ahmad F
- Al Asadi T
- Al Awwad S
- Al Ayed A
- Al Habes H
- Al Riyami S
- AL Sayed M
- Alaa S
- AlAamer O
- Aladeojebi A
- Alagoa Joao A
- Alakaloko Felix
- Alam F
- Alameer Ehab
- Alamri Alex
- Alanazi F
- Alawneh F
- Albaqami F
- Albertsmeier M
- Albertsmeier Markus
- Alcaide Matas F
- Alconchel F
- AlcĂĄzar JA
- Alderson Derek
- Aldokali N
- AleksiÄ L
- Alemanno G
- Alfaifi J
- Alfieri S
- Alfonso Garcia M
- Algallai M
- Alghamdi M
- Alghuliga A
- Alhamed A
- Alharthi M
- Alhassan N
- Ali karar AA
- Ali Sani S
- Ali AA
- Ali M
- Ali S
- Alishi Y
- Aliyeva Z
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- Alkadiki Ghadah Z
- Alkhateb S
- Allue M
- Almaadany Faraj S
- Almassaudi A
- Almeida AC
- Almeida JI
- AlmeidaâReis R
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- Alnumani T
- Alobaysi S
- Alobeed O
- Alonso de la Fuente N
- Alonso Poza A
- AlonsoâLamberti L
- Alqahtani D
- Alqannas M
- Alrahawy M
- Alsayadi M
- Alsayadi R
- Alselaim N
- Alser Osaid
- Alshaar Muhammad
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- Alshareea E
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- Alsharif F
- Alshryda Sattar
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- Altomare DF
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- Alzaede S
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- Amaral MJ
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- Anania G
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- Angelou D
- Angenete E
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- Annessi V
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- Arulanantham A
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- Attia D
- Augestad Knut Magne
- Avci EK
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- Ayasra Faris
- Ayasra Y
- Aydin C
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- Ayorinde J
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- Balasubramaniam D
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- Barlow Emma
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- Bigam D
- Bigelow B
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- Bozkurt MA
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- Bravo Ana Minaya
- Breen Kerry A
- Bretherton Chris
- Brewer H
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- Bromage Steve
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- Bywater Edward
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- Capezzuoli L
- CapitanâMorales L
- Capkinoglu E
- Capolupo GT
- Capunge I
- CarabiasâOrgaz A
- Caram EL
- Carannante F
- Carbone F
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- Catena F
- Cato LD
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- Charre L
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- Chaturvedi A
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- Chatzikomnitsa P
- Chaudhry Daoud
- Chavarrias N
- Che jusoh A
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- Chebaro A
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- Chessa A
- Cheung J
- Cheung LK
- Chevallay M
- Chia Z
- Chiappini A
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- Chinda J
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- Chitul A
- Chiva Luis
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- Yetkin G
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- Yildiz A
- Yildiz A
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- Yousof EA
- Youssef M
- Yurttas C
- YĂĄnez C
- YĂŒksel E
- Zafar SN
- Zakaria AD
- Zakaria Z
- Zakharenko A
- Zambon M
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- Zegarac M
- ZeliÄ M
- Zengin AK
- Zerbib P
- Zervas K
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- Zhang H
- Zizzo M
- Zmora O
- Zografos C
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- Zourntou S
- Zubaidi A
- Ăngelo M
- ĂlgĂ„ A
- Ăelebi F
- Ăolak E
- Ăfner D
- Ăhlberger L
- Ăzant A
- Ăzçay N
- ĂÄĂŒcĂŒ H
- ĂberrĂŒck L
- Äoza I
- Ćawnicka A
- ĆœateckĂœ J
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2022
- Field of study
AimThe SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery.MethodsThis was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4âweeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin.ResultsOverall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4âweeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, PÂ =Â 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, PâConclusionOne in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease