Radio pulsar populations

The goal of this article is to summarize the current state of play in the field of radio pulsar statistics. Simply put, from the observed sample of objects from a variety of surveys with different telescopes, we wish to infer the properties of the underlying sample and to connect these with other astrophysical populations (for example supernova remnants or X-ray binaries). The main problem we need to tackle is the fact that, like many areas of science, the observed populations are often heavily biased by a variety of selection effects. After a review of the main effects relevant to radio pulsars, I discuss techniques to correct for them and summarize some of the most recent results. Perhaps the main point I would like to make in this article is that current models to describe the population are far from complete and often suffer from strong covariances between input parameters. That said, there are a number of very interesting conclusions that can be made concerning the evolution of neutron stars based on current data. While the focus of this review will be on the population of isolated Galactic pulsars, I will also briefly comment on millisecond and binary pulsars as well as the pulsar content of globular clusters and the Magellanic Clouds.Comment: 16 pages, 6 figures, to appear in Proceedings of ICREA Workshop on The High-Energy Emission from Pulsars and their Systems, Sant Cugat, Spain, 2010 April 12-16 (Springer

Binary and Millisecond Pulsars at the New Millennium

We review the properties and applications of binary and millisecond pulsars. Our knowledge of these exciting objects has greatly increased in recent years, mainly due to successful surveys which have brought the known pulsar population to over 1300. There are now 56 binary and millisecond pulsars in the Galactic disk and a further 47 in globular clusters. This review is concerned primarily with the results and spin-offs from these surveys which are of particular interest to the relativity community.Comment: 59 pages, 26 figures, 5 tables. Accepted for publication in Living Reviews in Relativity (http://www.livingreviews.org

Synaptically evoked glutamate transporter currents in Spinal Dorsal Horn Astrocytes

<p>Abstract</p> <p>Background</p> <p>Removing and sequestering synaptically released glutamate from the extracellular space is carried out by specific plasma membrane transporters that are primarily located in astrocytes. Glial glutamate transporter function can be monitored by recording the currents that are produced by co-transportation of Na⁺ions with the uptake of glutamate. The goal of this study was to characterize glutamate transporter function in astrocytes of the spinal cord dorsal horn in real time by recording synaptically evoked glutamate transporter currents.</p> <p>Results</p> <p>Whole-cell patch clamp recordings were obtained from astrocytes in the spinal substantia gelatinosa (SG) area in spinal slices of young adult rats. Glutamate transporter currents were evoked in these cells by electrical stimulation at the spinal dorsal root entry zone in the presence of bicuculline, strychnine, DNQX and D-AP5. Transporter currents were abolished when synaptic transmission was blocked by TTX or Cd²⁺. Pharmacological studies identified two subtypes of glutamate transporters in spinal astrocytes, GLAST and GLT-1. Glutamate transporter currents were graded with stimulus intensity, reaching peak responses at 4 to 5 times activation threshold, but were reduced following low-frequency (0.1 – 1 Hz) repetitive stimulation.</p> <p>Conclusion</p> <p>These results suggest that glutamate transporters of spinal astrocytes could be activated by synaptic activation, and recording glutamate transporter currents may provide a means of examining the real time physiological responses of glial cells in spinal sensory processing, sensitization, hyperalgesia and chronic pain.</p

Biological characteristics and treatment outcomes of metastatic or recurrent neuroendocrine tumors: tumor grade and metastatic site are important for treatment strategy

<p>Abstract</p> <p>Background</p> <p>Studies about the biology, treatment pattern, and treatment outcome of metastatic/recurrent neuroendocrine tumor (NET) have been few.</p> <p>Methods</p> <p>We enrolled patients with metastatic/recurrent NET diagnosed between January 1996 and July 2007 and retrospectively analyzed.</p> <p>Results</p> <p>A total of 103 patients were evaluated. Twenty-six patients (25.2%) had pancreatic NET, 27 (26.2%) had gastrointestinal NET, 2 (1.9%) had lung NET, 28 (27.2%) had NET from other sites, and 20 (19.4%) had NET from unknown origin. The liver was the most common metastatic site (68.9%). Thirty-four patients had grade 1 disease, 1 (1.0%) had grade 2 disease, 15 (14.6%) had grade 3 disease, 9 (8.7%) had large cell disease, and 7 (6.8%) had small cell disease.</p> <p>Sixty-six patients received systemic treatment (interferon, somatostatin analogues or chemotherapy), 64 patients received local treatment (TACE, radiofrequency ablation, metastasectomy, etc.). Thirty-six patients received both systemic and local treatments.</p> <p>Median overall survival (OS) was 29.0 months (95% confidence interval, 25.0-33.0) in the103 patients. OS was significantly influenced by grade (<it>p </it>= .001). OS was 43.0, 23.0, and 29.0 months in patients who received local treatment only, systemic treatment only, and both treatments, respectively (<it>p </it>= .245). The median time-to-progression (TTP) was 6.0 months. Overall response rate was 34.0% and disease-control rate was 64.2%. TTP was influenced by the presence of liver metastasis (<it>p </it>= .011).</p> <p>Conclusions</p> <p>OS of metastatic/recurrent NET was different according to tumor grade. TTP was different according to metastasis site. Therefore, development of optimal treatment strategy based on the characteristics of NET is warranted.</p

P-Type ATPase TAT-2 Negatively Regulates Monomethyl Branched-Chain Fatty Acid Mediated Function in Post-Embryonic Growth and Development in C. elegans

Monomethyl branched-chain fatty acids (mmBCFAs) are essential for Caenorhabditis elegans growth and development. To identify factors acting downstream of mmBCFAs for their function in growth regulation, we conducted a genetic screen for suppressors of the L1 arrest that occurs in animals depleted of the 17-carbon mmBCFA C17ISO. Three of the suppressor mutations defined an unexpected player, the P-type ATPase TAT-2, which belongs to the flippase family of proteins that are implicated in mediating phospholipid bilayer asymmetry. We provide evidence that TAT-2, but not other TAT genes, has a specific role in antagonizing the regulatory activity of mmBCFAs in intestinal cells. Interestingly, we found that mutations in tat-2 also suppress the lethality caused by inhibition of the first step in sphingolipid biosynthesis. We further showed that the fatty acid side-chains of glycosylceramides contain 20%–30% mmBCFAs and that this fraction is greatly diminished in the absence of mmBCFA biosynthesis. These results suggest a model in which a C17ISO-containing sphingolipid may mediate the regulatory functions of mmBCFAs and is negatively regulated by TAT-2 in intestinal cells. This work indicates a novel connection between a P-type ATPase and the critical regulatory function of a specific fatty acid

Pulse Profile Variability of PSR J1022+1001 in NANOGrav Data

\ua9 2025. The Author(s). Published by the American Astronomical Society.Pulse profile stability is a central assumption of standard pulsar timing methods. Thus, it is important for pulsar timing array experiments such as the North American Nanohertz Observatory for Gravitational Waves (NANOGrav) to account for any pulse profile variability present in their data sets. We show that in the NANOGrav 15 yr data set, the integrated pulse profile of PSR J1022+1001 as seen by the Arecibo radio telescope at 430, 1380, and 2030 MHz varies considerably in its shape from observation to observation. We investigate the possibility that this is due to the “ideal feed assumption” (IFA), on which NANOGrav’s routine polarization calibration procedure relies. PSR J1022+1001 is ∼90% polarized in one pulse profile component, and also has significant levels of circular polarization. Time-dependent deviations in the feed’s polarimetric response (PR) could cause mixing between the intensity I and the other Stokes parameters, leading to the observed variability. We calibrate the PR using a mixture of measurement equation modeling and measurement equation template matching techniques. The resulting profiles are no less variable than those calibrated using the IFA method, nor do they provide an improvement in the timing quality of this pulsar. We observe the pulse shape in 25 MHz bandwidths to vary consistently across the band, which cannot be explained by interstellar scintillation in combination with profile evolution with frequency. Instead, we favor phenomena intrinsic to the pulsar as the cause

The Anomalous Acceleration of PSR J2043+1711: Long-period Orbital Companion or Stellar Flyby?

\ua9 2025. The Author(s). Published by the American Astronomical Society.Based on the rate of change of its orbital period, PSR J2043+1711 has a substantial peculiar acceleration of 3.5 \ub1 0.8 mm s-1 yr-1, which deviates from the acceleration predicted by equilibrium Milky Way (MW) models at a 4σ level. The magnitude of the peculiar acceleration is too large to be explained by disequilibrium effects of the MW interacting with orbiting dwarf galaxies (∼1 mm s-1 yr-1), and too small to be caused by period variations due to the pulsar being a redback. We identify and examine two plausible causes for the anomalous acceleration: a stellar flyby, and a long-period orbital companion. We identify a main-sequence star in Gaia DR3 and Pan-STARRS DR2 with the correct mass, distance, and on-sky position to potentially explain the observed peculiar acceleration. However, the star and the pulsar system have substantially different proper motions, indicating that they are not gravitationally bound. However, it is possible that this is an unrelated star that just happens to be located near J2043+1711 along our line of sight (chance probability of 1.6%). Therefore, we also constrain possible orbital parameters for a circumbinary companion in a hierarchical triple system with J2043+1711; the changes in the spindown rate of the pulsar are consistent with an outer object that has an orbital period of 60 kyr, a companion mass of 0.3 M⊙ (indicative of a white dwarf or low-mass star), and a semimajor axis of 1900 au. Continued timing and/or future faint optical observations of J2043+1711 may eventually allow us to differentiate between these scenarios