Improved Measurements of Partial Rate Asymmetry in B -> h h Decays

We report improved measurements of the partial rate asymmetry (Acp) in B -> h h decays with 140fb^-1 of data collected with the Belle detector at the KEKB e+e- collider. Here h stands for a charged or neutral pion or kaon and in total five decay modes are included: K-+ pi+-, K0s pi-+, K-+ pi0, pi-+ pi0 and K0s pi0. The flavor of the last decay mode is determined from the accompanying B meson. Using a data sample 4.7 times larger than that of our previous measurement, we find Acp(K-+ pi+-) -0.088+-0.035+-0.013, 2.4 sigma from zero. Results for other decay modes are also presented.Comment: 9 pages, 1 figur

Search for D-0-D-0(-) mixing in D-0 -> K+pi(-) decays and measurement of the doubly-Cabibbo-suppressed decay rate

We have searched for mixing in the Ddegrees-(D) over cap (0) D-0 system by measuring the decay-time distribution of D0 ! K(+)pi(-) decays. The analysis uses 90 fb(-1) of data collected by the Belle detector at the KEKB e(+) e(-) collider. We fit the decay-time distribution for the mixing parameters x(1) and y(1) and also for the parameter R-D, which is the ratio of the rate for the doubly-Cabibbo-suppressed decay D-0--> K(+)pi(-) to that for the Cabibbo-favored decay D-0 --> K- pi(+). We do these fits both assuming CP conservation and allowing for CP violation. We use a frequentist method to obtain a 95% C. L. region in the x(J2)- y(l) plane. Assuming no mixing, we measure R-D=(0: 381 +/- 0: 017 (+) (0.008)(-0.016))%

Spatial navigation deficits — overlooked cognitive marker for preclinical Alzheimer disease?

Detection of incipient Alzheimer disease (AD) pathophysiology is critical to identify preclinical individuals and target potentially disease-modifying therapies towards them. Current neuroimaging and biomarker research is strongly focused in this direction, with the aim of establishing AD fingerprints to identify individuals at high risk of developing this disease. By contrast, cognitive fingerprints for incipient AD are virtually non-existent as diagnostics and outcomes measures are still focused on episodic memory deficits as the gold standard for AD, despite their low sensitivity and specificity for identifying at-risk individuals. This Review highlights a novel feature of cognitive evaluation for incipient AD by focusing on spatial navigation and orientation deficits, which are increasingly shown to be present in at-risk individuals. Importantly, the navigation system in the brain overlaps substantially with the regions affected by AD in both animal models and humans. Notably, spatial navigation has fewer verbal, cultural and educational biases than current cognitive tests and could enable a more uniform, global approach towards cognitive fingerprints of AD and better cognitive treatment outcome measures in future multicentre trials. The current Review appraises the available evidence for spatial navigation and/or orientation deficits in preclinical, prodromal and confirmed AD and identifies research gaps and future research priorities

Evidence for direct CP violation in B-0 -> K+pi(-) decays

We report evidence for direct CP violation in the decay B-0-->K(+)pi(-) with 253 fb(-1) of data collected with the Belle detector at the KEKB e(+)e(-) collider. Using 275x10(6) B(B) over bar pairs we observe a B-->K(+/-)pi(-/+) signal with 2140+/-53 events. The measured CP violating asymmetry is A(CP)(K(+)pi(-))=-0.101+/-0.025(stat)+/-0.005(syst), corresponding to a significance of 3.9sigma including systematics. We also search for CP violation in the decays B+-->K(+)pi(0) and B+-->pi(+)pi(0). The measured CP violating asymmetries are A(CP)(K(+)pi(0))=0.04+/-0.05(stat)+/-0.02(syst) and A(CP)(pi(+)pi(0))=-0.02+/-0.10(stat)+/-0.01(syst), corresponding to the intervals -0.05< A(CP)(K(+)pi(0))<0.13 and -0.18< A(CP)(pi(+)pi(0))<0.14 at 90% confidence level

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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Observation of large CP violation and evidence for direct CP violation in B0+p- decays

We report the first observation of CP violation in B0+p- decays based on 152x106 U(4S)B (B) over bar decays collected with the Belle detector at the KEKB asymmetric-energy e+e- collider. We reconstruct a B0+p- CP eigenstate and identify the flavor of the accompanying B meson from its decay products. From the distribution of the time intervals between the two B meson decay points, we obtain App=+0.580.15(stat)0.07(syst) and Spp=-1.000.21(stat)0.07(syst). We rule out the CP-conserving case, App=Spp=0, at a level of 5.2 standard deviations. We also find evidence for direct CP violation with a significance at or greater than 3.2 standard deviations for any Spp value

Measurement of polarization and triple-product correlations in B -> phi K-* decays

We present measurements of decay amplitudes and triple-product correlations in B ->phi K-* decays based on 253 fb(-1) of data recorded at the Upsilon(4S) resonance with the Belle detector at the KEKB e(+)e(-) storage ring. The decay amplitudes for the three different helicity states are determined from the angular distributions of final-state particles. The longitudinal polarization amplitudes are found to be 0.45 +/- 0.05 +/- 0.02 for B-0->phi K-*0 and 0.52 +/- 0.08 +/- 0.03 for B+->phi K*+ decays. CP- and T-odd CP-violating triple-product asymmetries are measured to be consistent with zero

Measurements of B decays to two kaons

We report measurements of B meson decays to two kaons using 253 fb(-1) of data collected with the Belle detector at the KEKB energy-asymmetric e(+)e(-) collider. We find evidence for signals in B+->(K) over bar K-0(+) and B-0-> K-0(K) over bar (0) with significances of 3.0 sigma and 3.5 sigma, respectively. (Charge-conjugate modes are included.) The corresponding branching fractions are measured to be B(B+->(K) over bar K-0(+))=(1.0 +/- 0.4 +/- 0.1)x10(-6) and B(B-0-> K-0(K) over bar (0))=(0.8 +/- 0.3 +/- 0.1)x10(-6). These decay modes are examples of hadronic b -> d transitions. No signal is observed in the decay B-0-> K+K-, and we set an upper limit of 3.7x10(-7) at 90% confidence level

Measurements of the D-sJ resonance properties

We report measurements of the properties of the D-sJ(+)(2317) and D-sJ(+)(2457) resonances produced in continuum e(+)e(-) annihilation near roots=10.6 GeV. The analysis is based on an 86.9 fb(-1) data sample collected with the Belle detector at KEKB. We determine the masses to be M(D-sJ(+)(2317))=2317.2+/-0.5(stat)+/-0.9(syst) MeV/c(2) and M(D-sJ(+)(2457))=2456.5+/-1.3(stat)+/-1.3(syst) MeV/c(2). We observe the radiative decay mode D-sJ(+)(2457)-->D(s)(+)gamma and the dipion decay mode D-sJ(+)(2457)-->D(s)(+)pi(+)pi(-) and determine their branching fractions. No corresponding decays are observed for the D-sJ(2317) state. These results are consistent with the spin-parity assignments of 0(+) for the D-sJ(2317) and 1(+) for the D-sJ(2457)