Fetal Growth versus Birthweight: The Role of Placenta versus Other Determinants

in utero. We aimed to study the effects of maternal characteristics on both birthweight and fetal growth in third trimester and introduce placental weight as a possible determinant of both birthweight and fetal growth in third trimester.The STORK study is a prospective cohort study including 1031 healthy pregnant women of Scandinavian heritage with singleton pregnancies. Maternal determinants (age, parity, body mass index (BMI), gestational weight gain and fasting plasma glucose) of birthweight and fetal growth estimated by biometric ultrasound measures were explored by linear regression models. Two models were fitted, one with only maternal characteristics and one which included placental weight.Placental weight was a significant determinant of birthweight. Parity, BMI, weight gain and fasting glucose remained significant when adjusted for placental weight. Introducing placental weight as a covariate reduced the effect estimate of the other variables in the model by 62% for BMI, 40% for weight gain, 33% for glucose and 22% for parity. Determinants of fetal growth were parity, BMI and weight gain, but not fasting glucose. Placental weight was significant as an independent variable. Parity, BMI and weight gain remained significant when adjusted for placental weight. Introducing placental weight reduced the effect of BMI on fetal growth by 23%, weight gain by 14% and parity by 17%.In conclusion, we find that placental weight is an important determinant of both birthweight and fetal growth. Our findings indicate that placental weight markedly modifies the effect of maternal determinants of both birthweight and fetal growth. The differential effect of third trimester glucose on birthweight and growth parameters illustrates that birthweight and fetal growth are not identical entities

Health literacy and substance use in young Swiss men.

OBJECTIVES: The purpose of the present study was to describe health literacy and its association with substance use among young men. METHODS: The present study was part of the Cohort Study on Substance Use Risk Factors that included 11,930 Swiss males participating in initial screening from August 2010 to July 2011. Self-completed questionnaires covered use of three substances and three components of health literacy. RESULTS: Roughly 22 % reported having searched the Internet for health information and 16 % for information on substances over the past 12 months. At-risk and not at-risk users of alcohol (adjusted odds ratio (AOR) = 2.50 and 1.46), tobacco (AOR = 2.51 and 1.79) and cannabis (AOR = 4.86 and 3.53) searched for information about substances significantly more often via the Internet than abstainers. Furthermore, at-risk users reported better knowledge of risks associated with substance use and a marginally better ability to understand health information than abstainers. CONCLUSIONS: Substance users appear to be more informed and knowledgeable about the risks of substance use than non-users. Consequently, interventions that focus only on information provision may be of limited benefit for preventing substance use

Life-cycle modification in open oceans accounts for genome variability in a cosmopolitan phytoplankton

Emiliania huxleyi is the most abundant calcifying plankton in modern oceans with substantial intraspecific genome variability and a biphasic life cycle involving sexual alternation between calcified 2N and flagellated 1N cells. We show that high genome content variability in Emiliania relates to erosion of 1N-specific genes and loss of the ability to form flagellated cells. Analysis of 185 E. huxleyi strains isolated from world oceans suggests that loss of flagella occurred independently in lineages inhabiting oligotrophic open oceans over short evolutionary timescales. This environmentally linked physiogenomic change suggests life cycling is not advantageous in very large/diluted populations experiencing low biotic pressure and low ecological variability. Gene loss did not appear to reflect pressure for genome streamlining in oligotrophic oceans as previously observed in picoplankton. Life-cycle modifications might be common in plankton and cause major functional variability to be hidden from traditional taxonomic or molecular markers

Delineation of fluvial sediment architecture of subalpine riverine systems using noninvasive hydrogeophysical methods

River management and restoration measures are of increasing importance for integrated water resources management (IWRM) as well as for ecosystem services. However, often river management mainly considers engineering and construction aspects only and the hydrogeological settings as the properties and functions of ancient fluvial systems are neglected which often do not lead to the desired outcome. Knowledge of the distribution of sediment units could contribute to a more efficient restoration. In this study, we present two noninvasive approaches for delineation of fluvial sediment architecture that can form a basis for the restoration, particularly in areas where site disturbance is not permitted. We investigate the floodplain of a heavily modified low-mountain river in Switzerland using different hydrogeophysical methods. In the first approach, we use data from electromagnetic induction (EMI) with four different integral depths (0.75–6 m) and gamma-spectrometry as well as the elevation data as input for a K-means cluster algorithm. The generated cluster map of the surface combines the main characteristics from multilayered input data and delineates areas of varying soil properties. The resulting map provides an indication of areas with different sedimentary units. In the second approach, we develop a new iterative method for the generation of a geological structure model (GSM) by means of various EMI forward models. We vary the geological input parameters based on the measured data until the predicted EMI maps match the measured EMI values. Subsequently, we use the best matched input data for the GSM generation. The derived GSM provides a 3D delineation of possible ancient stream courses. A comparison with an independent ground penetrating radar (GPR) profile confirmed the delineations on the cluster map as well as the vertical changes of the GSM qualitatively. Thus, each of the approaches had the capacity for detecting sedimentary units with distinct hydraulic properties as an indication of former stream courses. The developed methodology presents a promising tool for the characterization of test sites with no additional subsurface information