Entrepreneurs’ age, institutions, and social value creation goals: a multi-country study

This study explores the relationship between an entrepreneur's age and his/her social value creation goals. Building on the lifespan developmental psychology literature and institutional theory, we hypothesize a U-shaped relationship between entrepreneurs’ age and their choice to create social value through their ventures, such that younger and older entrepreneurs create more social value with their businesses while middle age entrepreneurs are relatively more economically and less socially oriented with their ventures. We further hypothesize that the quality of a country’s formal institutions in terms of economic, social, and political freedom steepen the U-shaped relationship between entrepreneurs’ age and their choice to pursue social value creation as supportive institutional environments allow entrepreneurs to follow their age-based preferences. We confirm our predictions using multilevel mixed-effects linear regressions on a sample of over 15,000 entrepreneurs (aged between 18 and 64 years) in 45 countries from Global Entrepreneurship Monitor data. The findings are robust to several alternative specifications. Based on our findings, we discuss implications for theory and practice, and we propose future research directions

Great expectations for earthquake early warnings on the United States West Coast

© 2022 The AuthorsIn October 2019, California became the first state in the United States to fully activate a public earthquake early warning system—ShakeAlert®—managed by the U.S. Geological Survey. The system was subsequently rolled out in March 2021 in Oregon and May 2021 in Washington. Earthquake early warning (EEW) systems can provide seconds of notice to people and technological systems that shaking is imminent, but their effectiveness depends on recipients’ expectations and actions as well as technical performance. To better understand these dependencies, we surveyed representative samples of adults in California (N = 1219), Oregon (N = 1020), and Washington (N = 1037) in February 2021. Most respondents had experienced earthquakes, but few had lived through violent shaking; most had not followed protective action guidance to Drop, Cover, and Hold On (DCHO) in earthquakes; and most reported no personal or social harm from prior earthquakes. Nevertheless, expectations and perceived usefulness of EEW were high, and higher still for those who expected alerts to be accurate and easy to use, expressed tolerance of missed and erroneous warnings, and expected to be affected by a damaging earthquake in their lifetime. Results suggest opportunities to better align public preferences and expectations with ShakeAlert operations. For example, some respondents preferred lower alerting thresholds than those proposed by government and scientists. Moreover, reported tolerance of warning errors was widespread, but respondents wanted explanations quickly, suggesting a need to further develop post-alert messaging. Findings from this study should be informative for future research on the co-evolution of experiences and expectations with EEW systems

Deletion of Porcn in Mice Leads to Multiple Developmental Defects and Models Human Focal Dermal Hypoplasia (Goltz Syndrome)

Focal Dermal Hypoplasia (FDH) is a genetic disorder characterized by developmental defects in skin, skeleton and ectodermal appendages. FDH is caused by dominant loss-of-function mutations in X-linked PORCN. PORCN orthologues in Drosophila and mice encode endoplasmic reticulum proteins required for secretion and function of Wnt proteins. Wnt proteins play important roles in embryo development, tissue homeostasis and stem cell maintenance. Since features of FDH overlap with those seen in mouse Wnt pathway mutants, FDH likely results from defective Wnt signaling but molecular mechanisms by which inactivation of PORCN affects Wnt signaling and manifestations of FDH remain to be elucidated.We introduced intronic loxP sites and a neomycin gene in the mouse Porcn locus for conditional inactivation. Porcn-ex3-7flox mice have no apparent developmental defects, but chimeric mice retaining the neomycin gene (Porcn-ex3-7Neo-flox) have limb, skin, and urogenital abnormalities. Conditional Porcn inactivation by EIIa-driven or Hprt-driven Cre recombinase results in increased early embryonic lethality. Mesenchyme-specific Prx-Cre-driven inactivation of Porcn produces FDH-like limb defects, while ectodermal Krt14-Cre-driven inactivation produces thin skin, alopecia, and abnormal dentition. Furthermore, cell-based assays confirm that human PORCN mutations reduce WNT3A secretion.These data indicate that Porcn inactivation in the mouse produces a model for human FDH and that phenotypic features result from defective WNT signaling in ectodermal- and mesenchymal-derived structures

Social Determinants Contribute to Disparities in Test Positivity, Morbidity and Mortality: Data from a Multi-Ethnic Cohort of 1094 GU Cancer Patients Undergoing Assessment for COVID-19

Background: The COVID-19 pandemic exploits existing inequalities in the social determinants of health (SDOH) that influence disease burden and access to healthcare. The role of health behaviours and socioeconomic status in genitourinary (GU) malignancy has also been highlighted. Our aim was to evaluate predictors of patient-level and neighbourhood-level factors contributing to disparities in COVID-19 outcomes in GU cancer patients. Methods: Demographic information and co-morbidities for patients screened for COVID-19 across the Mount Sinai Health System (MSHS) up to 10 June 2020 were included. Descriptive analyses and ensemble feature selection were performed to describe the relationships between these predictors and the outcomes of positive SARS-CoV-2 RT-PCR test, COVID-19-related hospitalisation, intubation and death. Results: Out of 47,379 tested individuals, 1094 had a history of GU cancer diagnosis; of these, 192 tested positive for SARS-CoV-2. Ensemble feature selection identified social determinants including zip code, race/ethnicity, age, smoking status and English as the preferred first language—being the majority of significant predictors for each of this study’s four COVID-19-related outcomes: a positive test, hospitalisation, intubation and death. Patient and neighbourhood level SDOH including zip code/ NYC borough, age, race/ethnicity, smoking status, and English as preferred language are amongst the most significant predictors of these clinically relevant outcomes for COVID-19 patients. Conclusion: Our results highlight the importance of these SDOH and the need to integrate SDOH in patient electronic medical records (EMR) with the goal to identify at-risk groups. This study’s results have implications for COVID-19 research priorities, public health goals, and policy implementations

Síndrome de Goltz: relato de dois casos Goltz syndrome: report of two cases

A hipoplasia dérmica focal é genodermatose rara, de caráter dominante, ligada ao cromossoma X. Os autores apresentam dois casos dessa síndrome, destacando suas principais características dermatológicas e a importância da avaliação multidisciplinar em seu diagnóstico e acompanhamento.<br>Focal dermal hypoplasia is a rare X-linked dominant genodermatosis. Two cases of Goltz-Gorlin syndrome are reported, showing the clinical manifestations, necessity of multidisciplinary evaluation, diagnosis and continuous follow-up

Correlates of chronic disease and patient–provider discussions among middle-aged and older adult males: Implications for successful aging and sexuality

Objective: Effective erectile dysfunction (ED) treatments and cardiovascular disease (CVD) and diabetes risk assessments are available, but require patientprovider communication. The present study explored this issue using 2010 National Social Life, Health and Aging Project data for males age 57 years and older (n=1011).Methods: Multinomial logistic regression was performed to compare factors associated with being without CVD/diabetes (39.9%), being diagnosed with CVD only (43.1%), and having comorbid CVD/diabetes (CVD 17.0%). Logistic regression compared factors associated with having ever discussed sexual issues with physicians.Results: CVD-only participants were more likely to be ≥75 years (p=0.004) and smoke (p=0.019); CVD&D participants were more likely to report activity limitations (p\u3c0.001) and less likely to have sex within the previous year (p=0.014). Compared to CVD-only, men with CVD&D were more likely to be minorities, obese, have daily activity limitations, and report erectile difficulties (all p\u3c0.05). Males discussing sexual issues with physicians were more likely to report higher education [OR=1.68, p=0.001], have sex in previous year [OR1.73, p=0.006], and have erectile difficulties [OR2.26, p\u3c0.001].Discussion: Increased patient and provider awareness and communication are needed to lifestyle behaviors, promote self-care practices, and improve health care utilization among male patients affected by chronic disease and ED. © 2012 Informa UK, Ltd