155 research outputs found
Two cases of perivascular epithelioid cell tumor of the uterus: clinical, radiological and pathological diagnostic challenge
Cosmic ray diffusion near the Bohm limit in the Cassiopeia A supernova remnant
Supernova remnants (SNRs) are believed to be the primary location of the
acceleration of Galactic cosmic rays, via diffusive shock (Fermi) acceleration.
Despite considerable theoretical work the precise details are still unknown, in
part because of the difficulty in directly observing nucleons that are
accelerated to TeV energies in, and affect the structure of, the SNR shocks.
However, for the last ten years, X-ray observatories ASCA, and more recently
Chandra, XMM-Newton, and Suzaku have made it possible to image the synchrotron
emission at keV energies produced by cosmic-ray electrons accelerated in the
SNR shocks. In this article, we describe a spatially-resolved spectroscopic
analysis of Chandra observations of the Galactic SNR Cassiopeia A to map the
cutoff frequencies of electrons accelerated in the forward shock. We set upper
limits on the electron diffusion coefficient and find locations where particles
appear to be accelerated nearly as fast as theoretically possible (the Bohm
limit).Comment: 18 pages, 5 figures. Accepted for publication in Nature Physics (DOI
below), final version available week of August 28, 2006 at
http://www.nature.com/nphy
Intraventricular dyssynchrony in light chain amyloidosis: a new mechanism of systolic dysfunction assessed by 3-dimensional echocardiography
<p>Abstract</p> <p>Background</p> <p>Light chain amyloidosis (AL) is a rare but often fatal disease due to intractable heart failure. Amyloid deposition leads to diastolic dysfunction and often preserved ejection fraction. We hypothesize that AL is associated with regional systolic dyssynchrony. The aim is to compare left ventricular (LV) regional synchrony in AL subjects versus healthy controls using 16-segment dyssynchrony index measured from 3-dimension-al (3D) echocardiography.</p> <p>Methods</p> <p>Cardiac 3D echocardiography full volumes were acquired in 10 biopsy-proven AL subjects (60 ± 3 years, 5 females) and 10 healthy controls (52 ± 1 years, 5 females). The LV was subdivided into 16 segments and the time from end-diastole to the minimal systolic volume for each of the 16 segments was expressed as a percent of the cycle length. The standard deviations of these times provided a 16-segment dyssynchrony index (16-SD%). 16-SD% was compared between healthy and AL subjects.</p> <p>Results</p> <p>Left ventricular ejection fraction was comparable (control vs. AL: 62.4 ± 0.6 vs. 58.6 ± 2.8%, p = NS). 16-SD% was significantly higher in AL versus healthy subjects (5.93 ± 4.4 vs. 1.67 ± 0.87%, p = 0.003). 16-SD% correlated with left ventricular mass index (R 0.45, p = 0.04) but not to left ventricular ejection fraction.</p> <p>Conclusion</p> <p>Light chain amyloidosis is associated with left ventricular regional systolic dyssynchrony. Regional dyssynchrony may be an unrecognized mechanism of heart failure in AL subjects.</p
Visualization of Abscess Formation in a Murine Thigh Infection Model of Staphylococcus aureus by 19F-Magnetic Resonance Imaging (MRI)
Background: During the last years, 19 F-MRI and perfluorocarbon nanoemulsion (PFC) emerged as a powerful contrast agent based MRI methodology to track cells and to visualize inflammation. We applied this new modality to visualize deep tissue abscesses during acute and chronic phase of inflammation caused by Staphylococcus aureus infection. Methodology and Principal Findings: In this study, a murine thigh infection model was used to induce abscess formation and PFC or CLIO (cross linked ironoxides) was administered during acute or chronic phase of inflammation. 24 h after inoculation, the contrast agent accumulation was imaged at the site of infection by MRI. Measurements revealed a strong accumulation of PFC at the abscess rim at acute and chronic phase of infection. The pattern was similar to CLIO accumulation at chronic phase and formed a hollow sphere around the edema area. Histology revealed strong influx of neutrophils at the site of infection and to a smaller extend macrophages during acute phase and strong influx of macrophages at chronic phase of inflammation. Conclusion and Significance: We introduce 19 F-MRI in combination with PFC nanoemulsions as a new platform to visualize abscess formation in a murine thigh infection model of S. aureus. The possibility to track immune cells in vivo by this modality offers new opportunities to investigate host immune response, the efficacy of antibacterial therapies and th
Molecular targeted therapies in head and neck cancer - An update of recent developements -
Targeted therapies have made their way into clinical practice during the past decade. They have caused a major impact on the survival of cancer patients in many areas of clinical oncology and hematology. Indeed, in some hematologic malignancies, such as chronic myelogenous leukemia or non-Hodgkin's lymphomas, biologicals and antibodies specifically designed to target tumour-specific proteins have revolutionized treatment standards. In solid tumours, new drugs targeting EGF- or VEGF- receptors are now approved and are entering clinical practise for treatment of colon, lung, kidney and other cancers, either alone or in combination with conventional treatment approaches
Use of the anterior-posterior chest diameter in CT: reduction in radiation dose?
Vascular Biology and Interventio
Cardiac resynchronization therapy guided by late gadolinium-enhancement cardiovascular magnetic resonance
320-row CT: does beat-to-beat motion of the coronary arteries affect image quality?
Vascular Biology and Interventio
Functional analysis by 64-slice CT scanning: prediction of left ventricular dysfunction together with reduction in radiation exposure?
Cardiac Dysfunction and Arrhythmia
- …