The kinematic and thermohaline zonation of the Antarctic Circumpolar Current at Drake Passage

The waters of the Antarctic Circumpolar Current at Drake Passage show mesoscale horizontal zonation into four water mass regimes horizontally separated by three fronts. Vertical profiles of T, S and O2 on opposite sides of each front are described and compared. Although the surface waters are significantly different across fronts, the vertical profiles from the same side of a specific front are remarkably uniform from year to year and from cruise to cruise...

Repeated nutrient, oxygen, and density sections through the Loop Current

Based on observations made in May, 1972, the nutrient and dissolved-oxygen concentrations in the offshore waters of the eastern Gulf of Mexico are described and related to the Loop Current and anticyclonic current rings, which are the principal circulation features of this region. The characteristic relationships of oxygen and nutrients to density parameters are presented..

Transcriptional repression by ApiAP2 factors is central to chronic toxoplasmosis

Tachyzoite to bradyzoite development in Toxoplasma is marked by major changes in gene expression resulting in a parasite that expresses a new repertoire of surface antigens hidden inside a modified parasitophorous vacuole called the tissue cyst. The factors that control this important life cycle transition are not well understood. Here we describe an important transcriptional repressor mechanism controlling bradyzoite differentiation that operates in the tachyzoite stage. The ApiAP2 factor, AP2IV-4, is a nuclear factor dynamically expressed in late S phase through mitosis/cytokinesis of the tachyzoite cell cycle. Remarkably, deletion of the AP2IV-4 locus resulted in the expression of a subset of bradyzoite-specific proteins in replicating tachyzoites that included tissue cyst wall components BPK1, MCP4, CST1 and the surface antigen SRS9. In the murine animal model, the mis-timing of bradyzoite antigens in tachyzoites lacking AP2IV-4 caused a potent inflammatory monocyte immune response that effectively eliminated this parasite and prevented tissue cyst formation in mouse brain tissue. Altogether, these results indicate that suppression of bradyzoite antigens by AP2IV-4 during acute infection is required for Toxoplasma to successfully establish a chronic infection in the immune-competent host

The importance of the Scotia Sea on the outflow of Weddell Sea Deep Water

Weddell Sea Deep Water influences the thermohaline circulation of the world ocean directly as a component of the deep western boundary current in the South Atlantic Ocean and indirectly by cooling and freshening Circumpolar Deep Water. Because it is filled with recently ventilated Weddell Sea Deep Water, the Scotia Sea is important to both influences. The main component of the abyssal waters renewing most of the world oceans via deep boundary currents is the Circumpolar Deep Water of the Antarctic Circumpolar Current. Weddell Sea Deep Water is recognized as the main source of cold, fresh waters to Circumpolar Deep Water, and we show that Weddell Sea Deep Water is incorporated into the Antarctic Circumpolar Current within the Scotia Sea. As a result of this ventilation, the Scotia Sea provides an effective link between the deep waters of the Weddell Sea and the rest of the world abyssal ocean. Some of the Weddell Sea Deep Water filling the Scotia Sea leaves as a westward flow via the southern Drake Passage. Weddell Sea Deep Water also enters the Georgia Basin directly from the Scotia Sea and flows beneath the Antarctic Circumpolar Current to contribute to the deep western boundary current of the Argentine Basin. In most previous studies, a deep spreading route from the Weddell Sea over the South Sandwich Trench east of the Scotia Sea had been considered the only source of Weddell Sea Deep Water for this deep western boundary current