APPLEBAUM SCHOLARSHIP PAPER: EXPORT BEHAVIOR AND ATTITUDES OF AUSTRALASIA MEAT INDUSTRY FIRMS: A NORTH AMERICAN MARKET FOCUS

International Relations/Trade,

Comparing community resources to industrial needs with application to Daviess County, Missouri

A method of matching industries with communities, the modified Miller-Weiss Indugram, is developed. The technique compares the environmental needs of industry with the environmental resources of a community. The comparison is based upon twenty-five environmental factors. Application of the technique is made to Daviess County, Missouri. Results indicate those industries which are best suited for this rural area --Abstract, page ii

The UPC\u27s New Survivorship and Antilapse Provisions

Law governing transfers of family property has long struggled with questions of survivorship in their many and varied forms. Important results can and regularly do turn on how such issues are resolved

An Overview of Lessons Learned from Sonic-boom Flight Research Projects Conducted by NASA Armstrong Flight Research Center

Over the course of four years, a team of aerospace engineers at the National Aeronautics and Space Administration Armstrong Flight Research Center completed four projects, each with the objective to research sonic-boom signatures from a ground-and building-level perspective. The relatively compressed timeline of these projects resulted in many lessons learned. With each successive project, these lessons have been more relied upon and referenced. This paper provides a high-level overview of the teams relevant lessons learned and the importance of these lessons for future projects

Mineral concentrations in soil extracts, forages, and blood sera of cattle grazing on reclaimed uranium-mined land in southeastern Wyoming

The Pathfinder Uranium Mine which is located in southeastern Wyoming, was actively mined during the 1960's-1980's. Reclamation involved returning the spoil/overburden and replacing the salvaged topsoil. The area was revegetated in 1974-1977, but was not grazed until 1980-85. A grazing experiment was then conducted to determine solubility of mineral elements in soil, uptake by plants and absorption by grazing animals. Blood sera were collected at 28-30 day intervals during the three grazing/growing seasons in 1980-1982. Blood sera samples were frozen and later analyzed by ICP. When compared to published data, plants on the reclaimed site contained lower concentrations of Ca, Mg, Mn, P, and Zn; but higher concentrations of Cd, Cr and Ni than plants on adjacent undisturbed sites. When compared to expected blood sera data, animals grazing on the reclaimed site had lower concentrations of B. Ca, Cu, Mg, and Na; but higher concentrations of Cr and Fe than would be expected for most grazing animals. Livestock producers are advised to provide supplements of Ca, Mg, Mn, P, and Zn to minimize deficiency of these elements in livestock nutrition when grazing these reclaimed lands

In situ generation of Mes2Mg as a non-nucleophilic carbon-centred base reagent for the efficient one-pot conversion of ketones to silyl enol ethers

Treatment of commercially available MesMgBr with 1,4-dioxane produces the key Mes2Mg reagent in situ which then mediates the deprotonation of ketones to deliver trimethylsilyl enol ethers, at readily accessible temperatures and without any nucleophilic addition, in an expedient and high yielding one-pot process

Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity

Treatment of onchocerciasis using mass ivermectin administration has reduced morbidity and transmission throughout Africa and Central/South America. Mass drug administration is likely to exert selection pressure on parasites, and phenotypic and genetic changes in several Onchocerca volvulus populations from Cameroon and Ghana-exposed to more than a decade of regular ivermectin treatment-have raised concern that sub-optimal responses to ivermectin's anti-fecundity effect are becoming more frequent and may spread.Pooled next generation sequencing (Pool-seq) was used to characterise genetic diversity within and between 108 adult female worms differing in ivermectin treatment history and response. Genome-wide analyses revealed genetic variation that significantly differentiated good responder (GR) and sub-optimal responder (SOR) parasites. These variants were not randomly distributed but clustered in ~31 quantitative trait loci (QTLs), with little overlap in putative QTL position and gene content between the two countries. Published candidate ivermectin SOR genes were largely absent in these regions; QTLs differentiating GR and SOR worms were enriched for genes in molecular pathways associated with neurotransmission, development, and stress responses. Finally, single worm genotyping demonstrated that geographic isolation and genetic change over time (in the presence of drug exposure) had a significantly greater role in shaping genetic diversity than the evolution of SOR.This study is one of the first genome-wide association analyses in a parasitic nematode, and provides insight into the genomics of ivermectin response and population structure of O. volvulus. We argue that ivermectin response is a polygenically-determined quantitative trait (QT) whereby identical or related molecular pathways but not necessarily individual genes are likely to determine the extent of ivermectin response in different parasite populations. Furthermore, we propose that genetic drift rather than genetic selection of SOR is the underlying driver of population differentiation, which has significant implications for the emergence and potential spread of SOR within and between these parasite populations