Bela Bartok\u27s Scherzo for Piano and Orchestra , Op. 2: An Analytical Study.

This study examines Bela Bartok\u27s Scherzo for Piano and Orchestra, Op. 2 (1904), a work that was composed during a period when the composer\u27s style was about to undergo a radical change. Chapter One charts the course of Bartok\u27s training as a pianist, discusses his compositional influences, and provides a brief history of the Scherzo and its more familiar sibling, the Rhapsody for Piano and Orchestra, Op. 1. Chapter Two looks at the Scherzo in detail, addressing the following: the overall form, the harmonic plan, the size and use of the orchestra, the idiomatic piano writing, and the use of thematic transformation (or alteration). In the course of the description, several features are pointed out--namely: Bartok\u27s assimilation and (perhaps subconscious) imitation of certain stylistic characteristics of Brahms, Liszt, Wagner, and Strauss; the curious absence of the piano in approximately 60% of the work; the prevalent interval of the third; the numerous tempo changes; the expressive lyricism and exciting climaxes; and the use of humor in the mocking, jesting style. Chapter Three is a brief conclusion that summarizes the strengths and weaknesses of the Scherzo, revealing details of Bartok\u27s compositional style at the time the work was composed

Life spring thesis

Life spring thesi

Beyond complex Langevin equations II: a positive representation of Feynman path integrals directly in the Minkowski time

Recently found positive representation for an arbitrary complex, gaussian weight is used to construct a statistical formulation of gaussian path integrals directly in the Minkowski time. The positivity of Minkowski weights is achieved by doubling the number of real variables. The continuum limit of the new representation exists only if some of the additional couplings tend to infinity and are tuned in a specific way. The construction is then successfully applied to three quantum mechanical examples including a particle in a constant magnetic field -- a simplest prototype of a Wilson line. Further generalizations are shortly discussed and an intriguing interpretation of new variables is alluded to.Comment: 16 pages, 2 figures, references adde

Expanding Predictive Assessment of Northern Bobwhite Covey Calling Rates to Incorporate Regional Effects

Many surveys based on discrete vocalizations make the invalid assumption that individuals present in the survey area are always available for detection (e.g., calling) during the survey period. Northern bobwhites (Colinus virginianus) are known to exhibit variable calling rates, particularly during autumn covey surveys. Adjustment of density and abundance estimates to account for calling rate may increase reliability of population metrics, and may increase our ability to effectively assess conservation management. Two previous independent studies across 4 regions used logistic regression to evaluate effects of weather, time, and density covariates on calling rates of radio-marked autumn bobwhite coveys. Results from these studies varied and there is uncertainty regarding application without further investigation into regional differences in calling rates. We combined these data sets comprising known calling rates of 279 bobwhite coveys in 4 regions (Florida, Missouri, North Carolina, and Tennessee) from 1998 to 2000. Observed calling rates averaged 69% over all sites, and ranged from 56 to 80% in the Florida and Missouri regions, respectively. We used binomial logistic regression to evaluate effects of region, adjacent calling coveys, weekly period, change in barometric pressure, percent cloud cover, temperature, and wind speed on covey calling rates. The top ranking model suggested strong effects of region and number of adjacent coveys on calling probability (P , 0.0001) with 42% model weight relative to other candidate models. Two competing models suggested inclusion of the 6-hr change in barometric pressure (0100 – 0700 hrs) (18% model weight) or weekly period (17% model weight) might also be appropriate. Validation using the best approximating model (region þ adjacent coveys) suggested calling probability estimates were within 6% of the observed calling rate in one region. This suggests the predictive model may provide a valid estimator of calling rate when applied to covey survey data in the appropriate region. However, there is uncertainty regarding application of region-specific model coefficients to survey data outside of these regions. If effects of region are important predictors of calling rate, managers must be cognizant of these prior to adjusting parameter estimates. Further, there is a research need concerning utility and ubiquity of calling rate predictors, particularly for regions that lack known calling rate data

Effects of anisotropic interactions on the structure of animal groups

This paper proposes an agent-based model which reproduces different structures of animal groups. The shape and structure of the group is the effect of simple interaction rules among individuals: each animal deploys itself depending on the position of a limited number of close group mates. The proposed model is shown to produce clustered formations, as well as lines and V-like formations. The key factors which trigger the onset of different patterns are argued to be the relative strength of attraction and repulsion forces and, most important, the anisotropy in their application.Comment: 22 pages, 9 figures. Submitted. v1-v4: revised presentation; extended simulations; included technical results. v5: added a few clarification

A concept for trial institutions focussing on randomised controlled trials in surgery

<p>Abstract</p> <p>Background</p> <p>Although considered the reference standard for generating valid scientific evidence of a treatment's benefits and harms, the number of Randomised Controlled Trials (RCT) comparing surgical techniques remains low. Much effort has been made in order to overcome methodological issues and improve quality of RCTs in surgery. To the present there has been, however, only little emphasis on development and maintenance of institutions for implementation of adequately designed and conducted surgical RCTs.</p> <p>Mehods/Design</p> <p>Description of the developments in surgical RCT infrastructure in Germany between 2001 and 2006. Cross sectional evaluation of completed and ongoing surgical RCTs within the German Surgical Society and the Clinical Study Centre, Department of Surgery, University of Heidelberg.</p> <p>Results</p> <p>Foundation of a national Clinical Trial Centre (CTC) for the organisation of multi-centre RCTs in the surgical setting (Study Center of the German Surgical Society, SDGC). Establishment of a network of CTCs with affiliated Clinical Sites (CSs) to enhance patient recruitment and shorten the duration of RCTs. Since its foundation four surgical RCTs with a total sample size of 1650 patients (1006 of these randomised) have been supervised by the SDGC with 35 CSs involved in patient recruitment. Five further CTCs were set up in 2006. Together with their affiliated CSs a network has been organised providing improved conditions for the conduction of surgical RCTs.</p> <p>Conclusion</p> <p>Improvement of infrastructure substantially facilitates integration of RCTs into routine surgical practice. A network of collaborating CTCs and CSs can provide an adequate infrastructure for the conduction of multi-centre RCTs.</p

Intra-operative real time intracranial subarachnoid haemorrhage during glial tumour resection: A case report

Glial tumours associated with subarachnoid haemorrhage are very rare. A 64-year-old woman admitted with a history of 3 weeks seizures and a left sided hemiparesis and dysphasia. The magnetic resonance disclosed heterogeneously enhancing a right temporal mass. During surgery, suddenly an abrupt and extensive swelling had occurred both in tumour and the brain tissue. The surgery was completed with a gross total tumour resection together with a partial temporal lobectomy. Postoperative computerized tomography demonstrated a massive subarachnoid hemorrhage (SAH). A cerebral Magnetic Resonance (MR) angiography showed neither an aneurysm nor arteriovenous malformation. Coincidence of an intracerebral tumour and subarachnoid haemorrhage would be devastating

Quantitative cross-species extrapolation between humans and fish: The case of the anti-depressant fluoxetine

This article has been made available through the Brunel Open Access Publishing Fund.Fish are an important model for the pharmacological and toxicological characterization of human pharmaceuticals in drug discovery, drug safety assessment and environmental toxicology. However, do fish respond to pharmaceuticals as humans do? To address this question, we provide a novel quantitative cross-species extrapolation approach (qCSE) based on the hypothesis that similar plasma concentrations of pharmaceuticals cause comparable target-mediated effects in both humans and fish at similar level of biological organization (Read-Across Hypothesis). To validate this hypothesis, the behavioural effects of the anti-depressant drug fluoxetine on the fish model fathead minnow (Pimephales promelas) were used as test case. Fish were exposed for 28 days to a range of measured water concentrations of fluoxetine (0.1, 1.0, 8.0, 16, 32, 64 μg/L) to produce plasma concentrations below, equal and above the range of Human Therapeutic Plasma Concentrations (HTPCs). Fluoxetine and its metabolite, norfluoxetine, were quantified in the plasma of individual fish and linked to behavioural anxiety-related endpoints. The minimum drug plasma concentrations that elicited anxiolytic responses in fish were above the upper value of the HTPC range, whereas no effects were observed at plasma concentrations below the HTPCs. In vivo metabolism of fluoxetine in humans and fish was similar, and displayed bi-phasic concentration-dependent kinetics driven by the auto-inhibitory dynamics and saturation of the enzymes that convert fluoxetine into norfluoxetine. The sensitivity of fish to fluoxetine was not so dissimilar from that of patients affected by general anxiety disorders. These results represent the first direct evidence of measured internal dose response effect of a pharmaceutical in fish, hence validating the Read-Across hypothesis applied to fluoxetine. Overall, this study demonstrates that the qCSE approach, anchored to internal drug concentrations, is a powerful tool to guide the assessment of the sensitivity of fish to pharmaceuticals, and strengthens the translational power of the cross-species extrapolation

Custom Integrated Circuits

Contains reports on seven research projects.U.S. Air Force - Office of Scientific Research (Contract F49620-84-C-0004)National Science Foundation (Grant ECS81-18160)Defense Advanced Research Projects Agency (Contract NOO14-80-C-0622)National Science Foundation (Grant ECS83-10941

Custom Integrated Circuits

Contains reports on six research projects.U.S. Air Force - Office of Scientific Research (Contract F49620-84-C-0004)Analog Devices, Inc.Defense Advanced Research Projects Agency (Contract N00014-80-C-0622)National Science Foundation (Grant ECS83-10941