Uncertainty in strain-rate from field measurements of the geometry, rates and kinematics of active normal faults: Implications for seismic hazard assessment

Multiple measurements of the geometry, kinematics and rates of slip across the Auletta fault (Campania, Italy) are presented, and we use these to determine: (1) the spatial resolution of field measurements needed to accurately calculate a representative strain-rate; (2) what aspects of the geometry and kinematics would introduce uncertainty with regard to the strain-rate if not measured in the field. We find that the magnitude of the post last-glacial maximum throw across the fault varies along strike. If such variations are unnoticed, different values for a representative strain-rate, hence different results in seismic hazard calculations, would be produced. To demonstrate this, we progressively degrade our dataset, calculating the implied strain-rate at each step. Excluding measurements can alter strain-rate results beyond 1σ uncertainty, thus we urge caution when using only one measurement of slip-rate for calculating hazard. We investigate the effect of approximating the throw profile along the fault with boxcar and triangular distributions and show that this can underestimate or overestimate the strain-rate, with results in the range of 72–237% of our most detailed strain-rate calculation. We discuss how improved understanding of the potential implied errors in strain-rate calculations from field structural data should be implemented in seismic hazard calculations

Progression through emergency and temporary shelter, transitional housing and permanent housing: A longitudinal case study from the 2018 Lombok earthquake, Indonesia

Increasing quality while reducing the time and costs of progressing disaster-affected populations from emergency shelter to permanent housing is key for improving post-disaster resilience. However, targets set around quality and time are often overly optimistic; the process is complex and factors affecting the progression of shelter and housing through the initial weeks and months following a disaster are diverse and not well documented. To identify which contributors are key to recovery efforts and at what stages in the process they can help or hinder, we need to study post-disaster environments over time. This longitudinal study of the shelter and housing evolution over the first eight months following the August 2018 Lombok earthquake helps to provide some insight. We argue that unrealistic expectations over timelines and standards were set. We consider the humanitarian response through aid and grants, the role of individual actors, and wealth and location of those affected. Hampering overall recovery efforts were a lack of transitional housing policy, an overly complex grant process for permanent housing construction, and a failure to declare a national disaster in a politicised environment. Conversely, shelter vulnerability reduction (people moving into more secure shelter then housing) at household level was marginally affected by wealth, proximity to a regency centre, being in an urban location or receiving additional shelter aid in the first few months, but less influential four months following the disaster. Most households self-recovered, with those recovering fastest being the most proactive and adaptable, who were supported by an effective village leader

Cell wall modifications during conidial maturation of the human pathogenic fungus Pseudallescheria boydii

This is the final version of the article. Available from the publisher via the DOI in this record.Progress in extending the life expectancy of cystic fibrosis (CF) patients remains jeopardized by the increasing incidence of fungal respiratory infections. Pseudallescheria boydii (P. boydii), an emerging pathogen of humans, is a filamentous fungus frequently isolated from the respiratory secretions of CF patients. It is commonly believed that infection by this fungus occurs through inhalation of airborne conidia, but the mechanisms allowing the adherence of Pseudallescheria to the host epithelial cells and its escape from the host immune defenses remain largely unknown. Given that the cell wall orchestrates all these processes, we were interested in studying its dynamic changes in conidia as function of the age of cultures. We found that the surface hydrophobicity and electronegative charge of conidia increased with the age of culture. Melanin that can influence the cell surface properties, was extracted from conidia and estimated using UV-visible spectrophotometry. Cells were also directly examined and compared using electron paramagnetic resonance (EPR) that determines the production of free radicals. Consistent with the increased amount of melanin, the EPR signal intensity decreased suggesting polymerization of melanin. These results were confirmed by flow cytometry after studying the effect of melanin polymerization on the surface accessibility of mannose-containing glycoconjugates to fluorescent concanavalin A. In the absence of melanin, conidia showed a marked increase in fluorescence intensity as the age of culture increased. Using atomic force microscopy, we were unable to find rodlet-forming hydrophobins, molecules that can also affect conidial surface properties. In conclusion, the changes in surface properties and biochemical composition of the conidial wall with the age of culture highlight the process of conidial maturation. Mannose-containing glycoconjugates that are involved in immune recognition, are progressively masked by polymerization of melanin, an antioxidant that is commonly thought to allow fungal escape from the host immune defenses.The study was funded by “Région Pays de la Loire” in the frame of “Myco-AFM” research program). BED was supported by the Dutch Virgo Consortium (FES0908, NGI 050-060-452) and CAPES/BRASIL. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Influence of Fault System Geometry and Slip Rates on the Relative Role of Coseismic and Interseismic Stresses on Earthquake Triggering and Recurrence Variability

We model Coulomb stress transfer (CST) due to 30 strong earthquakes occurring on normal faults since 1509 CE in Calabria, Italy, including the influence of interseismic loading, and compare the results to existing studies of stress interaction from the Central and Southern Apennines, Italy. The three normal fault systems have different geometries and long‐term slip‐rates. We investigate the extent to which stress transfer can influence the occurrence of future earthquakes and what factors may govern the variability in earthquake recurrence in different fault systems. The Calabrian, Central Apennines, and Southern Apennines fault systems have 91%, 73%, and 70% of faults with mean positive cumulative CST in the time considered; this is due to fewer faults across strike, more across strike stress reductions, and greater along‐strike spacing in the three regions respectively. In regions with close along strike spacing or few faults across strike, such as Calabria and Southern Apennines, the stress loading history is mostly dominated by interseismic loading and most faults are positively stressed before an earthquake occur on them (96% of all faults that ruptured in Calabria; 94% of faults in Southern Apennines), and some of the strongest earthquakes occur on faults with the highest mean cumulative stress of all faults prior to the earthquake. In the Central Apennines, where across strike interactions are the predominant process, 79% of earthquakes occur on faults positively stressed. The results highlight that fault system geometry plays a central role in characterizing the stress evolution associated with earthquake recurrence

Behavioral Sequence Analysis Reveals a Novel Role for ß2* Nicotinic Receptors in Exploration

Nicotinic acetylcholine receptors (nAChRs) are widely expressed throughout the central nervous system and modulate neuronal function in most mammalian brain structures. The contribution of defined nAChR subunits to a specific behavior is thus difficult to assess. Mice deleted for ß2-containing nAChRs (ß2−/−) have been shown to be hyperactive in an open-field paradigm, without determining the origin of this hyperactivity. We here develop a quantitative description of mouse behavior in the open field based upon first order Markov and variable length Markov chain analysis focusing on the time-organized sequence that behaviors are composed of. This description reveals that this hyperactivity is the consequence of the absence of specific inactive states or “stops”. These stops are associated with a scanning of the environment in wild-type mice (WT), and they affect the way that animals organize their sequence of behaviors when compared with stops without scanning. They characterize a specific “decision moment” that is reduced in ß2−/− mutant mice, suggesting an important role of ß2-nAChRs in the strategy used by animals to explore an environment and collect information in order to organize their behavior. This integrated analysis of the displacement of an animal in a simple environment offers new insights, specifically into the contribution of nAChRs to higher brain functions and more generally into the principles that organize sequences of behaviors in animals

Anatomy of quantum chaotic eigenstates

The eigenfunctions of quantized chaotic systems cannot be described by explicit formulas, even approximate ones. This survey summarizes (selected) analytical approaches used to describe these eigenstates, in the semiclassical limit. The levels of description are macroscopic (one wants to understand the quantum averages of smooth observables), and microscopic (one wants informations on maxima of eigenfunctions, "scars" of periodic orbits, structure of the nodal sets and domains, local correlations), and often focusses on statistical results. Various models of "random wavefunctions" have been introduced to understand these statistical properties, with usually good agreement with the numerical data. We also discuss some specific systems (like arithmetic ones) which depart from these random models.Comment: Corrected typos, added a few references and updated some result

A European lens upon adult and lifelong learning in Asia

In this article, we seek to assess the extent to which adult and lifelong learning policies and practices in Asia have distinctiveness by comparison to those found in western societies, through an analysis of inter-governmental, national and regional policies in the field. We also inform our study through the analysis of the work of organisations with an international remit with a specific focus on Asia and Europe. In one case, the Asia–Europe Meeting Lifelong Learning (ASEM LLL) Hub has a specific function of bringing together researchers in Asia and Europe. In another, the PASCAL Observatory has had a particular focus on one aspect of lifelong learning, that of learning cities, with a concentration in its work on Asia and Europe. We focus on learning city development as a particular case of distinction in the field. We seek to identify the extent to which developments in the field in Asia have influenced and have been influenced by practices elsewhere in world, especially in Europe, and undertake our analysis using theories of societal learning/the learning society, learning communities and life-deep learning. We complement our analysis through assessment of material contained in three dominant journals in the field, the International Journal of Lifelong Education, the International Review of Education and Adult Education Quarterly, each edited in the west

Shh Signaling from the Nucleus Pulposus Is Required for the Postnatal Growth and Differentiation of the Mouse Intervertebral Disc

Intervertebral discs (IVD) are essential components of the vertebral column. They maintain separation, and provide shock absorbing buffers, between adjacent vertebrae, while also allowing movements between them. Each IVD consists of a central semi-liquid nucleus pulposus (NP) surrounded by a multi-layered fibrocartilagenous annulus fibrosus (AF). Although the IVDs grow and differentiate after birth along with the vertebral column, little is known about the mechanism of this. Understanding the signals that control normal IVD growth and differentiation would also provide potential therapies for degenerative disc disease, which is the major cause of lower back pain and affects a large proportion of the population. In this work, we show that during postnatal growth of the mouse, Sonic hedgehog (Shh) signaling from the NP cells controls many aspects of growth and differentiation of both the NP cells themselves and of the surrounding AF, and that it acts, at least partly, by regulating other signaling pathways in the NP and AF. Recent studies have shown that the NP cells arise from the embryonic notochord, which acts as a major signaling center in the embryo. This work shows that this notochord-derived tissue continues to carry out a major signaling function in the postnatal body and that the IVDs are signaling centers, in addition to their already known functions in the mechanics of vertebral column function

Neural correlates of sexual cue reactivity in individuals with and without compulsive sexual behaviours

Although compulsive sexual behaviour (CSB) has been conceptualized as a "behavioural" addiction and common or overlapping neural circuits may govern the processing of natural and drug rewards, little is known regarding the responses to sexually explicit materials in individuals with and without CSB. Here, the processing of cues of varying sexual content was assessed in individuals with and without CSB, focusing on neural regions identified in prior studies of drug-cue reactivity. 19 CSB subjects and 19 healthy volunteers were assessed using functional MRI comparing sexually explicit videos with non-sexual exciting videos. Ratings of sexual desire and liking were obtained. Relative to healthy volunteers, CSB subjects had greater desire but similar liking scores in response to the sexually explicit videos. Exposure to sexually explicit cues in CSB compared to non-CSB subjects was associated with activation of the dorsal anterior cingulate, ventral striatum and amygdala. Functional connectivity of the dorsal anterior cingulate-ventral striatum-amygdala network was associated with subjective sexual desire (but not liking) to a greater degree in CSB relative to non-CSB subjects. The dissociation between desire or wanting and liking is consistent with theories of incentive motivation underlying CSB as in drug addictions. Neural differences in the processing of sexual-cue reactivity were identified in CSB subjects in regions previously implicated in drug-cue reactivity studies. The greater engagement of corticostriatal limbic circuitry in CSB following exposure to sexual cues suggests neural mechanisms underlying CSB and potential biological targets for interventions

Bmcc1s, a Novel Brain-Isoform of Bmcc1, Affects Cell Morphology by Regulating MAP6/STOP Functions

The BCH (BNIP2 and Cdc42GAP Homology) domain-containing protein Bmcc1/Prune2 is highly enriched in the brain and is involved in the regulation of cytoskeleton dynamics and cell survival. However, the molecular mechanisms accounting for these functions are poorly defined. Here, we have identified Bmcc1s, a novel isoform of Bmcc1 predominantly expressed in the mouse brain. In primary cultures of astrocytes and neurons, Bmcc1s localized on intermediate filaments and microtubules and interacted directly with MAP6/STOP, a microtubule-binding protein responsible for microtubule cold stability. Bmcc1s overexpression inhibited MAP6-induced microtubule cold stability by displacing MAP6 away from microtubules. It also resulted in the formation of membrane protrusions for which MAP6 was a necessary cofactor of Bmcc1s. This study identifies Bmcc1s as a new MAP6 interacting protein able to modulate MAP6-induced microtubule cold stability. Moreover, it illustrates a novel mechanism by which Bmcc1 regulates cell morphology