80 research outputs found
Discovery of the progenitor of the type Ia supernova 2007on
Type Ia supernovae are exploding stars that are used to measure the
accelerated expansion of the Universe and are responsible for most of the iron
ever produced. Although there is general agreement that the exploding star is a
white dwarf in a binary system, the exact configuration and trigger of the
explosion is unclear, which could hamper their use for precision cosmology. Two
families of progenitor models have been proposed. In the first, a white dwarf
accretes material from a companion until it exceeds the Chandrasekhar mass,
collapses and explodes. Alternatively, two white dwarfs merge, again causing
catastrophic collapse and an explosion. It has hitherto been impossible to
determine if either model is correct. Here we report the discovery of an object
in pre-supernova archival X-ray images at the position of the recent type Ia
supernova (2007on) in the elliptical galaxy NGC 1404. Deep optical images (also
archival) show no sign of this object. From this we conclude that the X-ray
source is the progenitor of the supernova, which favours the accretion model
for this supernova, although the host galaxy is older (6-9 Gyr) than the age at
which the explosions are predicted in the accreting models.Comment: Published in Nature See also the two follow-up papers: Roelofs,
Bassa, Voss, Nelemans Nelemans, Voss, Roelofs, Bassa both on astro-ph
02/15/0
Compact High-Velocity Clouds at High Resolution
Six examples of the compact, isolated high-velocity clouds catalogued by
Braun & Burton (1999) and identified with a dynamically cold ensemble of
primitive objects falling towards the barycenter of the Local Group have been
imaged with the Westerbork Synthesis Radio Telescope; an additional ten have
been imaged with the Arecibo telescope. The imaging reveals a characteristic
core/halo morphology: one or several cores of cool, relatively
high-column-density material, are embedded in an extended halo of warmer,
lower-density material. Several of the cores show kinematic gradients
consistent with rotation; these CHVCs are evidently rotationally supported and
dark-matter dominated. The imaging data allows several independent estimates of
the distances to these objects, which lie in the range 0.3 to 1.0 Mpc. The CHVC
properties resemble what might be expected from very dark dwarf irregular
galaxies.Comment: 12 pages, 7 figures, to appear in "The Chemical Evolution of the
Milky Way: Stars versus Clusters", eds. F. Matteuchi and F. Giovannelli,
Kluwer Academic Publisher
The Distribution of Dust and Gas in Elliptical Galaxies
Results from IRAS and recent optical CCD surveys are examined to discuss the
distribution and origin of dust and ionized gas in elliptical galaxies. In
strong contrast with the situation among spiral galaxies, masses of dust in
elliptical galaxies as derived from optical extinction are an order of
magnitude LOWER than those derived from IRAS data. I find that this dilemma can
be resolved by assuming the presence of a diffusely distributed component of
dust which is not detectable in optical data.
The morphology of dust lanes and their association with ionized gas in
elliptical galaxies argues for an external origin of BOTH components of the
ISM.Comment: Invited talk given at conference on "NEW EXTRAGALACTIC PERSPECTIVES
IN THE NEW SOUTH AFRICA: Changing Perceptions of the Morphology, Dust Content
and Dust-Gas Ratios in Galaxies", Held in Johannesburg, South Africa, during
January 22-26, 1996. Proceedings will be edited by D.L. Block and published
by Kluwer, Dordrecht, The Netherlands. uuencoded, gzipped LaTeX file of 8
pages; figures included as PostScript files (enclosed). Uses crckapb.sty
(enclosed) and psfig.st
Discovery of molecular hydrogen in a high-velocity cloud of the Galactic halo
We report the discovery of molecular hydrogen absorption in a Galactic
high-velocity cloud (HVC) in the direction of the Large Magellanic Cloud. For
the same HVC we derive an iron abundance which is half of the solar value.
Thus, all evidence points to a Galactic origin for high-velocity cloud complex
in front of the LMC.Comment: Published in Nature, this week; 14 pages, 3 figure
Cold gas accretion in galaxies
Evidence for the accretion of cold gas in galaxies has been rapidly
accumulating in the past years. HI observations of galaxies and their
environment have brought to light new facts and phenomena which are evidence of
ongoing or recent accretion:
1) A large number of galaxies are accompanied by gas-rich dwarfs or are
surrounded by HI cloud complexes, tails and filaments. It may be regarded as
direct evidence of cold gas accretion in the local universe. It is probably the
same kind of phenomenon of material infall as the stellar streams observed in
the halos of our galaxy and M31. 2) Considerable amounts of extra-planar HI
have been found in nearby spiral galaxies. While a large fraction of this gas
is produced by galactic fountains, it is likely that a part of it is of
extragalactic origin. 3) Spirals are known to have extended and warped outer
layers of HI. It is not clear how these have formed, and how and for how long
the warps can be sustained. Gas infall has been proposed as the origin. 4) The
majority of galactic disks are lopsided in their morphology as well as in their
kinematics. Also here recent accretion has been advocated as a possible cause.
In our view, accretion takes place both through the arrival and merging of
gas-rich satellites and through gas infall from the intergalactic medium (IGM).
The infall may have observable effects on the disk such as bursts of star
formation and lopsidedness. We infer a mean ``visible'' accretion rate of cold
gas in galaxies of at least 0.2 Msol/yr. In order to reach the accretion rates
needed to sustain the observed star formation (~1 Msol/yr), additional infall
of large amounts of gas from the IGM seems to be required.Comment: To appear in Astronomy & Astrophysics Reviews. 34 pages.
Full-resolution version available at
http://www.astron.nl/~oosterlo/accretionRevie
Triptolide (TPL) Inhibits Global Transcription by Inducing Proteasome-Dependent Degradation of RNA Polymerase II (Pol II)
Triptolide (TPL), a key biologically active component of the Chinese medicinal herb Tripterygium wilfordii Hook. f., has potent anti-inflammation and anti-cancer activities. Its anti-proliferative and pro-apoptotic effects have been reported to be related to the inhibition of Nuclear Factor κB (NF-κB) and Nuclear Factor of Activated T-cells (NFAT) mediated transcription and suppression of HSP70 expression. The direct targets and precise mechanisms that are responsible for the gene expression inhibition, however, remain unknown. Here, we report that TPL inhibits global gene transcription by inducing proteasome-dependent degradation of the largest subunit of RNA polymerase II (Rpb1) in cancer cells. In the presence of proteosome inhibitor MG132, TPL treatment causes hyperphosphorylation of Rpb1 by activation of upstream protein kinases such as Positive Transcription Elongation Factor b (P-TEFb) in a time and dose dependent manner. Also, we observe that short time incubation of TPL with cancer cells induces DNA damage. In conclusion, we propose a new mechanism of how TPL works in killing cancer. TPL inhibits global transcription in cancer cells by induction of phosphorylation and subsequent proteasome-dependent degradation of Rpb1 resulting in global gene transcription, which may explain the high potency of TPL in killing cancer
Properties of galaxies reproduced by a hydrodynamic simulation.
Previous simulations of the growth of cosmic structures have broadly reproduced the 'cosmic web' of galaxies that we see in the Universe, but failed to create a mixed population of elliptical and spiral galaxies, because of numerical inaccuracies and incomplete physical models. Moreover, they were unable to track the small-scale evolution of gas and stars to the present epoch within a representative portion of the Universe. Here we report a simulation that starts 12 million years after the Big Bang, and traces 13 billion years of cosmic evolution with 12 billion resolution elements in a cube of 106.5 megaparsecs a side. It yields a reasonable population of ellipticals and spirals, reproduces the observed distribution of galaxies in clusters and characteristics of hydrogen on large scales, and at the same time matches the 'metal' and hydrogen content of galaxies on small scales
Dissociation of CAK from Core TFIIH Reveals a Functional Link between XP-G/CS and the TFIIH Disassembly State
Transcription factor II H (TFIIH) is comprised of core TFIIH and Cdk-activating kinase (CAK) complexes. Here, we investigated the molecular and cellular manifestation of the TFIIH compositional changes by XPG truncation mutations. We showed that both core TFIIH and CAK are rapidly recruited to damage sites in repair-proficient cells. Chromatin immunoprecipitation against TFIIH and CAK components revealed a physical engagement of CAK in nucleotide excision repair (NER). While XPD recruitment to DNA damage was normal, CAK was not recruited in severe XP-G and XP-G/CS cells, indicating that the associations of CAK and XPD to core TFIIH are differentially affected. A CAK inhibition approach showed that CAK activity is not required for assembling pre-incision machinery in vivo or for removing genomic photolesions. Instead, CAK is involved in Ser5-phosphorylation and UV-induced degradation of RNA polymerase II. The CAK inhibition impaired transcription from undamaged and UV-damaged reporter, and partially decreased transcription of p53-dependent genes. The overall results demonstrated that a) XP-G/CS mutations affect the disassembly state of TFIIH resulting in the dissociation of CAK, but not XPD from core TFIIH, and b) CAK activity is not essential for global genomic repair but involved in general transcription and damage-induced RNA polymerase II degradation
On the Origin of S0 Galaxies
I will review the basic properties of S0 galaxies in the local Universe in
relation to both elliptical and spiral galaxies, their neighbours on the Hubble
sequence, and also in relation to dwarf spheroidal (dSph) galaxies. This will
include colours, luminosities, spectral features, information about the age and
metallicity composition of their stellar populations and globular clusters,
about their ISM content, as well as kinematic signatures and their implications
for central black hole masses and past interaction events, and the number
ratios of S0s to other galaxy types in relation to environmental galaxy
density. I will point out some caveats as to their morphological discrimination
against other classes of galaxies, discuss the role of dust and the wavelength
dependence of bulge/disk light ratios. These effects are of importance for
investigations into the redshift evolution of S0 galaxies -- both as individual
objects and as a population. The various formation and transformation scenarios
for S0 and dSph galaxies will be presented and confronted with the available
observations.Comment: Invited Review, 18 pages, ``BARS 2004'' Conference, South Africa,
June 2004, eds.: K. C. Freeman, D. L. Block, I. Puerari, R. Groess, Kluwer,
in pres
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