161 research outputs found
Intercomparison of the northern hemisphere winter mid-latitude atmospheric variability of the IPCC models
We compare, for the overlapping time frame 1962-2000, the estimate of the
northern hemisphere (NH) mid-latitude winter atmospheric variability within the
XX century simulations of 17 global climate models (GCMs) included in the
IPCC-4AR with the NCEP and ECMWF reanalyses. We compute the Hayashi spectra of
the 500hPa geopotential height fields and introduce an integral measure of the
variability observed in the NH on different spectral sub-domains. Only two
high-resolution GCMs have a good agreement with reanalyses. Large biases, in
most cases larger than 20%, are found between the wave climatologies of most
GCMs and the reanalyses, with a relative span of around 50%. The travelling
baroclinic waves are usually overestimated, while the planetary waves are
usually underestimated, in agreement with previous studies performed on global
weather forecasting models. When comparing the results of various versions of
similar GCMs, it is clear that in some cases the vertical resolution of the
atmosphere and, somewhat unexpectedly, of the adopted ocean model seem to be
critical in determining the agreement with the reanalyses. The GCMs ensemble is
biased with respect to the reanalyses but is comparable to the best 5 GCMs.
This study suggests serious caveats with respect to the ability of most of the
presently available GCMs in representing the statistics of the global scale
atmospheric dynamics of the present climate and, a fortiori, in the perspective
of modelling climate change.Comment: 39 pages, 8 figures, 2 table
Disease Dynamics in a Specialized Parasite of Ant Societies
Coevolution between ant colonies and their rare specialized parasites are intriguing, because lethal infections of workers may correspond to tolerable chronic diseases of colonies, but the parasite adaptations that allow stable coexistence with ants are virtually unknown. We explore the trade-offs experienced by Ophiocordyceps parasites manipulating ants into dying in nearby graveyards. We used field data from Brazil and Thailand to parameterize and fit a model for the growth rate of graveyards. We show that parasite pressure is much lower than the abundance of ant cadavers suggests and that hyperparasites often castrate Ophiocordyceps. However, once fruiting bodies become sexually mature they appear robust. Such parasite life-history traits are consistent with iteroparity– a reproductive strategy rarely considered in fungi. We discuss how tropical habitats with high biodiversity of hyperparasites and high spore mortality has likely been crucial for the evolution and maintenance of iteroparity in parasites with low dispersal potential
Sensitivity of Asian Summer Monsoon precipitation to tropical sea surface temperature anomalies
Standardisation framework for the Maudsley staging method for treatment resistance in depression
Background:
Treatment-resistant depression (TRD) is a serious and relatively common clinical condition. Lack of consensus on defining and staging TRD remains one of the main barriers to understanding TRD and approaches to
intervention. The Maudsley Staging Method (MSM) is the first multidimensional model developed to define and stage treatment-resistance in “unipolar depression”. The model is being used increasingly in treatment and epidemiological studies of TRD and has the potential to support consensus. Yet, standardised methods for rating the MSM have not been described adequately. The aim of this report is to present standardised approaches for rating or completing the MSM.
Method:
Based on the initial development of the MSM and a narrative review of the literature, the developers of the
MSM provide explicit guidance on how the three dimensions of the MSM–treatment failure, severity of depressive
episode and duration of depressive episode– may be rated.
Result: The core dimension of the MSM, treatment failure, may be assessed using the Maudsley Treatment Inventory
(MTI), a new method developed for the purposes of completing the MSM. The MTI consists of a relatively comprehensive list of medications with options for rating doses and provisions treatment for multiple episodes. The second dimension, severity of symptoms, may be assessed using simple instruments such as the Clinical Global Impression, the Psychiatric Status Rating or checklist from a standard diagnostic checklist. The standardisation also provides a simple rating scale for scoring the third dimension, duration of depressive episode.
Conclusion:
The approaches provided should have clinical and research utility in staging TRD. However, in proposing this
model, we are fully cognisant that until the pathophysiology of depression is better understood, staging methods can only be tentative approximations. Future developments should attempt to incorporate other biological/ pathophysiological dimensions for staging
A putative functional role for oligodendrocytes in mood regulation
Altered glial structure and function is implicated in several major mental illnesses and increasing evidence specifically links changes in oligodendrocytes with disrupted mood regulation. Low density and reduced expression of oligodendrocyte-specific gene transcripts in postmortem human subjects points toward decreased oligodendrocyte function in most of the major mental illnesses. Similar features are observed in rodent models of stress-induced depressive-like phenotypes, such as the unpredictable chronic mild stress and chronic corticosterone exposure, suggesting an effect downstream from stress. However, whether oligodendrocyte changes are a causal component of psychiatric phenotypes is not known. Traditional views that identify oligodendrocytes solely as nonfunctional support cells are being challenged, and recent studies suggest a more dynamic role for oligodendrocytes in neuronal functioning than previously considered, with the region adjacent to the node of Ranvier (i.e., paranode) considered a critical region of glial–neuronal interaction. Here, we briefly review the current knowledge regarding oligodendrocyte disruptions in psychiatric disorders and related animal models, with a focus on major depression. We then highlight several rodent studies, which suggest that alterations in oligodendrocyte structure and function can produce behavioral changes that are informative of mood regulatory mechanisms. Together, these studies suggest a model, whereby impaired oligodendrocyte and possibly paranode structure and function can impact neural circuitry, leading to downstream effects related to emotionality in rodents, and potentially to mood regulation in human psychiatric disorders
Activation of locus coeruleus heme oxygenase-carbon monoxide pathway promoted an anxiolytic-like effect in rats
Impact of the LMDZ atmospheric grid configuration on the climate and sensitivity of the IPSL-CM5A coupled model
The use of visual and automatized behavioral markers to assess methodologies: a study case on PIT-tagging in the Alpine newt
peer reviewedBiomarkers are now widely used as tools in various research fields to assess individual integrity. The recent advances in quantification methods of behavioral patterns, such as computerized video-tracking procedures, make them valuable biomarkers. However, the corollary of these novelties is that they remain relatively unknown and unused. In this study, we show that such tools can assess the validity of research methods, such as individual recognition. To demonstrate this we employed as a model a marking method (Passive Integrate Transponders: PIT-tagging) widely used in amphibians. Both detailed visual observations and video-tracking methods were complementary in highlighting components at different behavioral scales: locomotion, feeding, and breeding. We illustrate the scientific and ethical adequacy of the targeted marking method but also suggest that more studies should integrate behavioral analyses. Such biomarkers are a powerful tool to assess conservation concerns when other techniques cannot detect detrimental effects
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