4,886 research outputs found
A fourth generation, anomalous like-sign dimuon charge asymmetry and the LHC
A fourth chiral generation, with in the range GeV and a moderate value of the CP-violating phase can explain the
anomalous like-sign dimuon charge asymmetry observed recently by the D0
collaboration. The required parameters are found to be consistent with
constraints from other and decays. The presence of such quarks, apart
from being detectable in the early stages of the LHC, would also have important
consequences in the electroweak symmetry breaking sector.Comment: 18 pages, 9 figures, Figure 1 is modified, more discussions are added
in section 2. new references adde
A Polarization-Imaging-Based Machine Learning Framework for Quantitative Pathological Diagnosis of Cervical Precancerous Lesions
Polarization images encode high resolution microstructural information even at low resolution. We propose a framework combining polarization imaging and traditional microscopy imaging, constructing a dual-modality machine learning framework that is not only accurate but also generalizable and interpretable. We demonstrate the viability of our proposed framework using the cervical intraepithelial neoplasia grading task, providing a polarimetry feature parameter to quantitatively characterize microstructural variations with lesion progression in hematoxylin-eosin-stained pathological sections of cervical precancerous tissues. By taking advantages of polarization imaging techniques and machine learning methods, the model enables interpretable and quantitative diagnosis of cervical precancerous lesion cases with improved sensitivity and accuracy in a low-resolution and wide-field system. The proposed framework applies routine image-analysis technology to identify the macro-structure and segment the target region in H&E-stained pathological images, and then employs emerging polarization method to extract the micro-structure information of the target region, which intends to expand the boundary of the current image-heavy digital pathology, bringing new possibilities for quantitative medical diagnosis
Quasi-static stop band with flexural metamaterial having zero rotational stiffness
Metamaterials realizing stop bands have attracted much attentions recently since they can break-through the well-known mass law. However, achieving the stop band at extremely low frequency has been still a big challenge in the fields of elastic metamaterials. In this paper, we propose a new metamaterial based on the idea of the zero rotational stiffness, to achieve extremely low frequency stop band for flexural elastic waves. Unlike the previous ways to achieve the stop band, we found that the zero rotational stiffness can provide a broad stop band at extremely low frequency, which starts from even almost zero frequency. To achieve the zero rotational stiffness, we propose a new elastic metamaterial consisting of blocks and links with the hinge connection. Analytic developments as well as numerical simulations evidence that this new metamaterial can exhibit extremely low and broad stop band, even at the quasi-static ranges. In addition, the metamaterial is shown to exhibit the negative group velocity at extremely low frequency ranges, as well as the quasi-static stop band, if it is properly designed.ope
Abnormal Stop Band Behavior Induced by Rotational Resonance in Flexural Metamaterial
This paper investigates abnormal stop band behavior of resonance-based flexural elastic metamaterials under the rotational resonance motion. Due to the unique physics of flexural waves, we found that the stop band generated by the rotational resonance motion exhibits peculiar behavior which are quite different from general belief - it is shown that the negativity due to the rotational resonance does not provide any stop bands and the stop band generation due to the rotational resonance is governed by totally different band gap condition. To explain the peculiar behavior, a discrete Timoshenko beam model with both effective mass and rotational inertia as independent variables is introduced, and the wave behaviors of resonance-based flexural elastic metamaterial are precisely and fully described. The unique band gap condition, including the peculiar behavior, is derived with numerical validations. We expect our new model can provide a strong background for various flexural elastic metamaterials which can be effectively applied in various vibration devices
Cis and trans regulatory mechanisms control AP2-mediated B cell receptor endocytosis via select tyrosine-based motifs.
Following antigen recognition, B cell receptor (BCR)-mediated endocytosis is the first step of antigen processing and presentation to CD4+ T cells, a crucial component of the initiation and control of the humoral immune response. Despite this, the molecular mechanism of BCR internalization is poorly understood. Recently, studies of activated B cell-like diffuse large B cell lymphoma (ABC DLBCL) have shown that mutations within the BCR subunit CD79b leads to increased BCR surface expression, suggesting that CD79b may control BCR internalization. Adaptor protein 2 (AP2) is the major mediator of receptor endocytosis via clathrin-coated pits. The BCR contains five putative AP2-binding Yxxร motifs, including four that are present within two immunoreceptor tyrosine-based activation motifs (ITAMs). Using a combination of in vitro and in situ approaches, we establish that the sole mediator of AP2-dependent BCR internalization is the membrane proximal ITAM Yxxร motif in CD79b, which is a major target of mutation in ABC DLBCL. In addition, we establish that BCR internalization can be regulated at a minimum of two different levels: regulation of Yxxร AP2 binding in cis by downstream ITAM-embedded DCSM and QTAT regulatory elements and regulation in trans by the partner cytoplasmic domain of the CD79 heterodimer. Beyond establishing the basic rules governing BCR internalization, these results illustrate an underappreciated role for ITAM residues in controlling clathrin-dependent endocytosis and highlight the complex mechanisms that control the activity of AP2 binding motifs in this receptor system
Improved Measurements of Partial Rate Asymmetry in B -> h h Decays
We report improved measurements of the partial rate asymmetry (Acp) in B -> h
h decays with 140fb^-1 of data collected with the Belle detector at the KEKB
e+e- collider. Here h stands for a charged or neutral pion or kaon and in total
five decay modes are included: K-+ pi+-, K0s pi-+, K-+ pi0, pi-+ pi0 and K0s
pi0. The flavor of the last decay mode is determined from the accompanying B
meson. Using a data sample 4.7 times larger than that of our previous
measurement, we find Acp(K-+ pi+-) -0.088+-0.035+-0.013, 2.4 sigma from zero.
Results for other decay modes are also presented.Comment: 9 pages, 1 figur
Study of the decays B->D_s1(2536)+ anti-D(*)
We report a study of the decays B -> D_s1(2536)+ anti-D(*), where anti-D(*)
is anti-D0, D- or D*-, using a sample of 657 x 10^6 B anti-B pairs collected at
the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric-energy
e+e- collider. The branching fractions of the decays B+ -> D_s1(2536)+ anti-D0,
B0 -> D_s1(2536)+ D- and B0 -> D_s1(2536)+ D*- multiplied by that of
D_s1(2536)+ -> (D*0K+ + D*+K0) are found to be (3.97+-0.85+-0.56) x 10^-4,
(2.75+-0.62+-0.36) x 10^-4 and (5.01+-1.21+-0.70) x 10^-4, respectively.Comment: 6 pages, 2 figues, submitted to PRD (RC
N-acetyltransferase 2 (NAT2) gene polymorphisms in colon and lung cancer patients
BACKGROUND: N-acetyltransferase 2 (NAT2) metabolizes arylamines and hydrazines moeities found in many therapeutic drugs, chemicals and carcinogens. The gene encoding NAT2 is polymorphic, thus resulting in rapid or slow acetylator phenotypes. The acetylator status may, therefore, predispose drug-induced toxicities and cancer risks, such as bladder, colon and lung cancer. Indeed, some studies demonstrate a positive association between NAT2 rapid acetylator phenotype and colon cancer, but results are inconsistent. The role of NAT2 acetylation status in lung cancer is likewise unclear, in which both the rapid and slow acetylator genotypes have been associated with disease. METHODS: We investigated three genetic variations, c.481C>T, c.590G>A (p.R197Q) and c.857G>A (p.G286E), of the NAT2 gene, which are known to result in a slow acetylator phenotype. Using validated PCR-RFLP assays, we genotyped 243 healthy unrelated Caucasian control subjects, 92 colon and 67 lung cancer patients for these genetic variations. As there is a recent meta-analysis of NAT2 studies on colon cancer (unlike in lung cancer), we have also undertaken a systematic review of NAT2 studies on lung cancer, and we incorporated our results in a meta-analysis consisting of 16 studies, 3,865 lung cancer patients and 6,077 control subjects. RESULTS: We did not obtain statistically significant differences in NAT2 allele and genotype frequencies in colon cancer patients and control group. Certain genotypes, however, such as [c.590AA+c.857GA] and [c.590GA+c.857GA] were absent among the colon cancer patients. Similarly, allele frequencies in lung cancer patients and controls did not differ significantly. Nevertheless, there was a significant increase of genotypes [c.590GA] and [c.481CT+c.590GA], but absence of homozygous c.590AA and [c.590AA+c.857GA] in the lung cancer group. Meta-analysis of 16 NAT2 studies on lung cancer did not evidence an overall association of the rapid or slow acetylator status to lung cancer. Similarly, the summary odds ratios obtained with stratified meta-analysis based on ethnicity, and smoking status were not significant. CONCLUSION: Our study failed to show an overall association of NAT2 genotypes to either colon or lung cancer risk
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