3,593 research outputs found
An Analysis of the Universal Home Care Program: Considerations for Implementation with the Context of Maine\u27s Existing LTSS Programs
A citizen initiative on the November 2018 ballot (Question 1, An Act to Establish Universal Home Care for Seniors and Persons with Disabilities) would establish a Universal Home Care Program (UHC Program) to serve older adults and persons with a disability living in Maine. This report does not constitute either support for or opposition to the referendum but is intended as an independent assessment of how the UHC Program could be implemented if it were to be approved by Maine voters. This analysis focuses on the implications of the UHC Program within the context of the Medicaid and state-funded long term services and supports programs currently administered by the Maine Department of Health and Human Services. The analysis assumes implementation would be guided by three goals: 1) avoiding an unintended negative impact on existing programs, 2) optimizing the use of public resources, and 3) advancing a community first model of care that promotes living at home when appropriate and preferred. This report does not address the financing or governance of the UHC Program as those are defined under the proposed legislation
Providing Long Term Services & Supports to People with Impaired Decision-Making Capacity: Results of Data Analysis and Interviews Examining Needs and Characteristics of Persons with Impaired Decision-Making Capacity in Maine
This document: Reviews the prevalence of impaired decision-making capacity among adults and older adults receiving publicly funded home care services and supports in Maine, the characteristics of this population group, and the caregivers caring for persons with impaired decision-making capacity. Reports on interviews with providers describing their ideas for helping people with impaired decisionmaking capacity live in the community longer. Reviews the legal status of persons receiving long term services and supports in Maine, including the presence of a guardian or a Power of Attorney, among those with impaired decision-making capacity across settings. Reports on interviews with providers, describing kinds of issues they encounter as they serve persons with impaired or deteriorating decision-making capacity
Professional Credentials -What Associated Schools of Construction (ASC) Members Are Doing
Professional Credentials have long been a part of the construction industry and many different credentials are available to the construction professional. Due to the number and variety of professional credentials it is often times difficult for individuals to decide which credentials are most advantageous to their career. ASC member schools with construction management programs have been conservative in the number and variety of professional credentials supported by their respective schools. ASC member schools have also not mirrored the construction industry in their support for certain professional credentials. This paper surveys the department heads of ASC member schools to decipher how they are incorporating professional credentials into their programs
Measuring vertebrate telomeres: applications and limitations
Telomeres are short tandem repeated sequences of DNA found at the ends of eukaryotic
chromosomes that function in stabilizing chromosomal end integrity.
In vivo
studies of
somatic tissue of mammals and birds have shown a correlation between telomere length and
organismal age within species, and correlations between telomere shortening rate and
lifespan among species. This result presents the tantalizing possibility that telomere length
could be used to provide much needed information on age, ageing and survival in natural
populations where longitudinal studies are lacking. Here we review methods available for
measuring telomere length and discuss the potential uses and limitations of telomeres as
age and ageing estimators in the fields of vertebrate ecology, evolution and conservation
Creating an interprofessional faculty and student global health grant program
UMB Center for Global Education Initiatives Founded in 2004 with an NIH Fogarty International Center “Framework” Grant that provided funds to universities to encourage capacity building & training in global health across schools on an academic campus. Focus: interprofessional global health educatio
Patterns of geohelminth infection, impact of albendazole treatment and re-infection after treatment in schoolchildren from rural KwaZulu-Natal/South-Africa
BACKGROUND: Geohelminth infection is a major health problem of children from rural areas of developing countries. In an attempt to reduce this burden, the Department of Health of the province of KwaZulu-Natal (KZN) established in 1998 a programme for helminth control that aimed at regularly treating primary school children for schistosomiasis and intestinal helminths. This article describes the baseline situation and the effect of treatment on geohelminth infection in a rural part of the province. METHODS: Grade 3 schoolchildren from Maputaland in northern KZN were examined for infections with hookworm, Ascaris lumbricoides, and Trichuris trichiura, treated twice with 400 mg albendazole and re-examined several times over one year after the first treatment in order to assess the impact of treatment and patterns of infection and re-infection. RESULTS: The hookworm prevalence in the study population (83.2%) was considerably higher than in other parts of the province whereas T. trichiura and especially A. lumbricoides prevalences (57.2 and 19.4%, respectively) were much lower than elsewhere on the KZN coastal plain. Single dose treatment with albendazole was very effective against hookworm and A. lumbricoides with cure rates (CR) of 78.8 and 96.4% and egg reduction rates (ERR) of 93.2 and 97.7%, respectively. It was exceptionally ineffective against T. trichiura (CR = 12.7%, ERR = 24.8%). Re-infection with hookworm and A. lumbricoides over 29 weeks after treatment was considerable but still well below pre-treatment levels. CONCLUSION: High geohelminth prevalences and re-infection rates in the study population confirm the need for regular treatment of primary school children in the area. The low effectiveness of single course albendazole treatment against T. trichiura infection however demands consideration of alternative treatment approaches
Translational Cancer Research: Balancing Prevention and Treatment to Combat Cancer Globally
Cancer research is drawing on the human genome project to develop new molecular-targeted treatments. This is an exciting but insufficient response to the growing, global burden of cancer, particularly as the projected increase in new cases in the coming decades is increasingly falling on developing countries. The world is not able to treat its way out of the cancer problem. However, the mechanistic insights from basic science can be harnessed to better understand cancer causes and prevention, thus underpinning a complementary public health approach to cancer control. This manuscript focuses on how new knowledge about the molecular and cellular basis of cancer, and the associated high-throughput laboratory technologies for studying those pathways, can be applied to population-based epidemiological studies, particularly in the context of large prospective cohorts with associated biobanks to provide an evidence base for cancer prevention. This integrated approach should allow a more rapid and informed translation of the research into educational and policy interventions aimed at risk reduction across a population
An Assessment of CO2 Storage and Sea‐Air Fluxes for the Atlantic Ocean and Mediterranean Sea Between 1985 and 2018
As part of the second phase of the Regional Carbon Cycle Assessment and Processes project (RECCAP2), we present an assessment of the carbon cycle of the Atlantic Ocean, including the Mediterranean Sea, between 1985 and 2018 using global ocean biogeochemical models (GOBMs) and estimates based on surface ocean carbon dioxide (CO2) partial pressure (pCO2 products) and ocean interior dissolved inorganic carbon observations. Estimates of the basin-wide long-term mean net annual CO2 uptake based on GOBMs and pCO2 products are in reasonable agreement (−0.47 ± 0.15 PgC yr−1 and −0.36 ± 0.06 PgC yr−1, respectively), with the higher uptake in the GOBM-based estimates likely being a consequence of a deficit in the representation of natural outgassing of land derived carbon. In the GOBMs, the CO2 uptake increases with time at rates close to what one would expect from the atmospheric CO2 increase, but pCO2 products estimate a rate twice as fast. The largest disagreement in the CO2 flux between GOBMs and pCO2 products is found north of 50°N, coinciding with the largest disagreement in the seasonal cycle and interannual variability. The mean accumulation rate of anthropogenic CO2 (Cant) over 1994–2007 in the Atlantic Ocean is 0.52 ± 0.11 PgC yr−1 according to the GOBMs, 28% ± 20% lower than that derived from observations. Around 70% of this Cant is taken up from the atmosphere, while the remainder is imported from the Southern Ocean through lateral transport
The Pioneer Anomaly
Radio-metric Doppler tracking data received from the Pioneer 10 and 11
spacecraft from heliocentric distances of 20-70 AU has consistently indicated
the presence of a small, anomalous, blue-shifted frequency drift uniformly
changing with a rate of ~6 x 10^{-9} Hz/s. Ultimately, the drift was
interpreted as a constant sunward deceleration of each particular spacecraft at
the level of a_P = (8.74 +/- 1.33) x 10^{-10} m/s^2. This apparent violation of
the Newton's gravitational inverse-square law has become known as the Pioneer
anomaly; the nature of this anomaly remains unexplained. In this review, we
summarize the current knowledge of the physical properties of the anomaly and
the conditions that led to its detection and characterization. We review
various mechanisms proposed to explain the anomaly and discuss the current
state of efforts to determine its nature. A comprehensive new investigation of
the anomalous behavior of the two Pioneers has begun recently. The new efforts
rely on the much-extended set of radio-metric Doppler data for both spacecraft
in conjunction with the newly available complete record of their telemetry
files and a large archive of original project documentation. As the new study
is yet to report its findings, this review provides the necessary background
for the new results to appear in the near future. In particular, we provide a
significant amount of information on the design, operations and behavior of the
two Pioneers during their entire missions, including descriptions of various
data formats and techniques used for their navigation and radio-science data
analysis. As most of this information was recovered relatively recently, it was
not used in the previous studies of the Pioneer anomaly, but it is critical for
the new investigation.Comment: 165 pages, 40 figures, 16 tables; accepted for publication in Living
Reviews in Relativit
Haemoglobin mass and running time trial performance after recombinant human erythropoietin administration in trained men
<p>Recombinant human erythropoietin (rHuEpo) increases haemoglobin mass (Hbmass) and maximal oxygen uptake (v˙ O2 max).</p>
<p>Purpose: This study defined the time course of changes in Hbmass, v˙ O2 max as well as running time trial performance
following 4 weeks of rHuEpo administration to determine whether the laboratory observations would translate into actual
improvements in running performance in the field.</p>
<p>Methods: 19 trained men received rHuEpo injections of 50 IUNkg21 body mass every two days for 4 weeks. Hbmass was
determined weekly using the optimized carbon monoxide rebreathing method until 4 weeks after administration. v˙ O2 max
and 3,000 m time trial performance were measured pre, post administration and at the end of the study.</p>
<p>Results: Relative to baseline, running performance significantly improved by ,6% after administration (10:3061:07 min:sec
vs. 11:0861:15 min:sec, p,0.001) and remained significantly enhanced by ,3% 4 weeks after administration
(10:4661:13 min:sec, p,0.001), while v˙ O2 max was also significantly increased post administration
(60.765.8 mLNmin21Nkg21 vs. 56.066.2 mLNmin21Nkg21, p,0.001) and remained significantly increased 4 weeks after
rHuEpo (58.065.6 mLNmin21Nkg21, p = 0.021). Hbmass was significantly increased at the end of administration compared to
baseline (15.261.5 gNkg21 vs. 12.761.2 gNkg21, p,0.001). The rate of decrease in Hbmass toward baseline values post
rHuEpo was similar to that of the increase during administration (20.53 gNkg21Nwk21, 95% confidence interval (CI) (20.68,
20.38) vs. 0.54 gNkg21Nwk21, CI (0.46, 0.63)) but Hbmass was still significantly elevated 4 weeks after administration
compared to baseline (13.761.1 gNkg21, p<0.001).</p>
<p>Conclusion: Running performance was improved following 4 weeks of rHuEpo and remained elevated 4 weeks after
administration compared to baseline. These field performance effects coincided with rHuEpo-induced elevated v˙ O2 max and
Hbmass.</p>
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