Type-Specific HPV Prevalence in Cervical Cancer and High-Grade Lesions in Latin America and the Caribbean: Systematic Review and Meta-Analysis

BACKGROUND: Cervical cancer is a major public health problem in Latin America and the Caribbean (LA&C), showing some of the highest incidence and mortality rates worldwide. Information on HPV type distribution in high-grade cervical lesions (HSIL) and invasive cervical cancer (ICC) is crucial to predict the future impact of HPV16/18 vaccines and screening programmes, and to establish an appropriate post-vaccinal virologic surveillance. The aim was to assess the prevalence of HPV types in HSIL and ICC in studies in LA&C. METHODS AND FINDINGS: We performed a systematic review, following the MOOSE guidelines for systematic reviews of observational studies, and the PRISMA statement for reporting systematic reviews and meta-analyses. Inclusion criteria were at least ten cases of HSIL/ICC, and HPV-type elicitation. The search, without language restrictions, was performed in MEDLINE, Cochrane Library, EMBASE, LILACS from inception date to December 2009, proceedings, reference lists and consulting experts. A meta-analysis was performed using arc-sine transformations to stabilize the variance of simple proportions. Seventy-nine studies from 18 countries were identified, including 2446 cases of HSIL and 5540 of ICC. Overall, 46.5% of HSIL cases harbored HPV 16 and 8.9% HPV18; in ICC, 53.2% of cases harbored HPV 16 and 13.2% HPV 18. The next five most common types, in decreasing frequency, were HPV 31, 58, 33, 45, and 52. Study's limitations comprise the cross-sectional design of most included studies and their inherent risk of bias, the lack of representativeness, and variations in the HPV type-specific sensitivity of different PCR protocols. CONCLUSIONS: This study is the broadest summary of HPV type distribution in HSIL and ICC in LA&C to date. These data are essential for local decision makers regarding HPV screening and vaccination policies. Continued HPV surveillance would be useful, to assess the potential for changing type-specific HPV prevalence in the post-vaccination era in Latin America

Revista de Saúde Pública: 50 years disseminating the knowledge in nutrition

ABSTRACT This work describes and comments on articles in the area of Public Health Nutrition published in Revista de Saúde Pública (RSP – Public Health Journal) from 1967 to 2016. We searched in the PubMed database restricted to the periodical “Revista de Saúde Pública” and using terms related to key topics in the area of Public Health Nutrition. We retrieved 742 articles and, after exclusion of duplicates and articles unrelated to the subject, we analyzed 441 articles, grouped according to subject: dental caries, anemia, hypovitaminosis A, macro/micronutrients, malnutrition, nutritional assessment, overweight/obesity, food consumption, low birthweight, and breastfeeding. We observed significant increase in the number of articles published and diversification of subjects addressed over the 50 years, representing the consistent development of the scientific field of Nutrition in Brazil. Since its inception, RSP has played an important role in the dissemination of knowledge about the main nutritional issues in Brazil

A dataset of fact-checked images shared on whatsapp during the brazilian and indian elections

Copyright © 2020, Association for the Advancement of Artificial Intelligence (www.aaai.org). All rights reserved. Recently, messaging applications, such as WhatsApp, have been reportedly abused by misinformation campaigns, especially in Brazil and India. A notable form of abuse in WhatsApp relies on several manipulated images and memes containing all kinds of fake stories. In this work, we performed an extensive data collection from a large set of WhatsApp publicly accessible groups and fact-checking agency websites. This paper opens a novel dataset to the research community containing fact-checked fake images shared through WhatsApp for two distinct scenarios known for the spread of fake news on the platform: the 2018 Brazilian elections and the 2019 Indian elections

Ruptura da Glândula Tiróide associada a Trauma Cervical Fechado – caso clínico

Although soft tissues injury in cervical trauma is relatively common, the injury of the thyroid is extremely rare, as we can see in English-language reports. The papers relate that trauma of the thyroid gland is quite rare in patients without preexisting goiter. This paper relates a blunt cervical trauma in a young woman without goiter disease that results in lesion of the thyroid diagnosed by computed tomography scan (CT) and that has been conduced conservatively, with a favorable course without further complications.Embora a lesão de partes moles no trauma cervical seja relativamente comum, a lesão da tiróide é extremamente rara, como ressalta a literatura em Inglês. Os trabalhos relatam que o trauma da glândula tiróide é muito raro em pacientes sem bócio pré-existente. Este artigo relata um caso de trauma cervical contuso numa mulher jovem sem bócio, que resultou em lesão da tiróide diagnosticada por tomografia computorizada (TC) e que foi conduzido de forma conservadora, com uma evolução favorável, sem complicações posteriores