388 research outputs found
A close halo of large transparent grains around extreme red giant stars
Intermediate-mass stars end their lives by ejecting the bulk of their
envelope via a slow dense wind back into the interstellar medium, to form the
next generation of stars and planets. Stellar pulsations are thought to elevate
gas to an altitude cool enough for the condensation of dust, which is then
accelerated by radiation pressure from starlight, entraining the gas and
driving the wind. However accounting for the mass loss has been a problem due
to the difficulty in observing tenuous gas and dust tens of milliarcseconds
from the star, and there is accordingly no consensus on the way sufficient
momentum is transferred from the starlight to the outflow. Here, we present
spatially-resolved, multi-wavelength observations of circumstellar dust shells
of three stars on the asymptotic giant branch of the HR diagram. When imaged in
scattered light, dust shells were found at remarkably small radii (<~ 2 stellar
radii) and with unexpectedly large grains (~300 nm radius). This proximity to
the photosphere argues for dust species that are transparent to starlight and
therefore resistant to sublimation by the intense radiation field. While
transparency usually implies insufficient radiative pressure to drive a wind,
the radiation field can accelerate these large grains via photon scattering
rather than absorption - a plausible mass-loss mechanism for lower-amplitude
pulsating stars.Comment: 13 pages, 1 table, 6 figure
A measurement of the 4He(g,n) reaction from 23 < Eg < 70 MeV
A comprehensive set of 4He(g,n) absolute cross-section measurements has been
performed at MAX-lab in Lund, Sweden. Tagged photons from 23 < Eg < 70 MeV were
directed toward a liquid 4He target, and neutrons were identified using
pulse-shape discrimination and the Time-of-flight Technique in two
liquid-scintillator detector arrays. Seven-point angular distributions have
been measured for fourteen photon energies. The results have been subjected to
complementary Transition-coefficient and Legendre-coefficient analyses. The
results are also compared to experimental data measured at comparable photon
energies as well as Recoil-Corrected Continuum Shell Model, Resonating Group
Method, and Effective Interaction Hyperspherical-Harmonic Expansion
calculations. For photon energies below 29 MeV, the angle-integrated data are
significantly larger than the values recommended by Calarco, Berman, and
Donnelly in 1983.Comment: 16 pages, 14 figures, some more revisions, submitted to Physical
Review
Why do Particle Clouds Generate Electric Charges?
Grains in desert sandstorms spontaneously generate strong electrical charges;
likewise volcanic dust plumes produce spectacular lightning displays. Charged
particle clouds also cause devastating explosions in food, drug and coal
processing industries. Despite the wide-ranging importance of granular charging
in both nature and industry, even the simplest aspects of its causes remain
elusive, because it is difficult to understand how inert grains in contact with
little more than other inert grains can generate the large charges observed.
Here, we present a simple yet predictive explanation for the charging of
granular materials in collisional flows. We argue from very basic
considerations that charge transfer can be expected in collisions of identical
dielectric grains in the presence of an electric field, and we confirm the
model's predictions using discrete-element simulations and a tabletop granular
experiment
Secondary flow and heat transfer coefficient distributions in the developing flow region of ribbed turbine blade cooling passages
In the Shadow of the Transiting Disk: Imaging epsilon Aurigae in Eclipse
Eclipses of the single-line spectroscopic binary star, epsilon Aurigae,
provide an opportunity to study the poorly-defined companion. We used the MIRC
beam combiner on the CHARA array to create interferometric images during
eclipse ingress. Our results demonstrate that the eclipsing body is a dark disk
that is opaque and tilted, and therefore exclude alternative models for the
system. These data constrain the geometry and masses of the components,
providing evidence that the F-star is not a massive supergiant star.Comment: As submitted to Nature. Published in Nature April 8, 2010
Changes in JC virus-specific T cell responses during natalizumab treatment and in natalizumab-associated progressive multifocal leukoencephalopathy
Progressive multifocal leukoencephalopathy (PML) induced by JC virus (JCV) is a risk for natalizumab-treated multiple sclerosis (MS) patients. Here we characterize the JCV-specific T cell responses in healthy donors and natalizumab-treated MS patients to reveal functional differences that may account for the development of natalizumab-associated PML. CD4 and CD8 T cell responses specific for all JCV proteins were readily identified in MS patients and healthy volunteers. The magnitude and quality of responses to JCV and cytomegalovirus (CMV) did not change from baseline through several months of natalizumab therapy. However, the frequency of T cells producing IL-10 upon mitogenic stimulation transiently increased after the first dose. In addition, MS patients with natalizumab-associated PML were distinguished from all other subjects in that they either had no detectable JCV-specific T cell response or had JCV-specific CD4 T cell responses uniquely dominated by IL-10 production. Additionally, IL-10 levels were higher in the CSF of individuals with recently diagnosed PML. Thus, natalizumab-treated MS patients with PML have absent or aberrant JCV-specific T cell responses compared with non-PML patients, and changes in T cell-mediated control of JCV replication may be a risk factor for developing PML. Our data suggest further approaches to improved monitoring, treatment and prevention of PML in natalizumab-treated patients
Gene expression and matrix turnover in overused and damaged tendons
Chronic, painful conditions affecting tendons, frequently known as tendinopathy, are very common types of sporting injury. The tendon extracellular matrix is substantially altered in tendinopathy, and these changes are thought to precede and underlie the clinical condition. The tendon cell response to repeated minor injuries or “overuse” is thought to be a major factor in the development of tendinopathy. Changes in matrix turnover may also be effected by the cellular response to physical load, altering the balance of matrix turnover and changing the structure and composition of the tendon. Matrix turnover is relatively high in tendons exposed to high mechanical demands, such as the supraspinatus and Achilles, and this is thought to represent either a repair or tissue maintenance function. Metalloproteinases are a large family of enzymes capable of degrading all of the tendon matrix components, and these are thought to play a major role in the degradation of matrix during development, adaptation and repair. It is proposed that some metalloproteinase enzymes are required for the health of the tendon, and others may be damaging, leading to degeneration of the tissue. Further research is required to investigate how these enzyme activities are regulated in tendon and altered in tendinopathy. A profile of all the metalloproteinases expressed and active in healthy and degenerate tendon is required and may lead to the development of new drug therapies for these common and debilitating sports injuries
Victim awareness : re-examining a probation fundamental
‘Ensuring offenders' awareness of the effects of crime on the victims of crime and the public’ is one of five stated aims of the National Probation Service of England and Wales and specifically undertaking victim awareness work is an expectation of the service’s work. The nature and putative value of such work appears to be rarely questioned however. It is argued that ‘victim awareness’ is a confused concept in terms of its rationale, definition, and empirical basis as a criminogenic need. These issues are evaluated and the practice implications discussed. A possible model of victim awareness work is described
Bacillus cereus Spores Release Alanine that Synergizes with Inosine to Promote Germination
spores germinate in the presence of a single germinant, inosine, yet with a significant lag period. spores. spores appear to have developed a unique quorum-sensing feedback mechanism to monitor spore density and to coordinate germination
The Society for Pediatric Anesthesia recommendations for the use of opioids in children during the perioperative period
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149726/1/pan13639_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149726/2/pan13639.pd
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