2,120 research outputs found
Effects of the genes for dwarfism (dw) and naked neck (Na) on chick growth and lipid metabolism
International audienc
Influence d'une modification de l'accroissement des dépÎts adipeux chez la poule pondeuse: Résultats d'une sélection divergente portant sur trois générations
International audienc
Big-Data-Driven Materials Science and its FAIR Data Infrastructure
This chapter addresses the forth paradigm of materials research -- big-data
driven materials science. Its concepts and state-of-the-art are described, and
its challenges and chances are discussed. For furthering the field, Open Data
and an all-embracing sharing, an efficient data infrastructure, and the rich
ecosystem of computer codes used in the community are of critical importance.
For shaping this forth paradigm and contributing to the development or
discovery of improved and novel materials, data must be what is now called FAIR
-- Findable, Accessible, Interoperable and Re-purposable/Re-usable. This sets
the stage for advances of methods from artificial intelligence that operate on
large data sets to find trends and patterns that cannot be obtained from
individual calculations and not even directly from high-throughput studies.
Recent progress is reviewed and demonstrated, and the chapter is concluded by a
forward-looking perspective, addressing important not yet solved challenges.Comment: submitted to the Handbook of Materials Modeling (eds. S. Yip and W.
Andreoni), Springer 2018/201
An Improved BKW Algorithm for LWE with Applications to Cryptography and Lattices
In this paper, we study the Learning With Errors problem and its binary
variant, where secrets and errors are binary or taken in a small interval. We
introduce a new variant of the Blum, Kalai and Wasserman algorithm, relying on
a quantization step that generalizes and fine-tunes modulus switching. In
general this new technique yields a significant gain in the constant in front
of the exponent in the overall complexity. We illustrate this by solving p
within half a day a LWE instance with dimension n = 128, modulus ,
Gaussian noise and binary secret, using
samples, while the previous best result based on BKW claims a time
complexity of with samples for the same parameters. We then
introduce variants of BDD, GapSVP and UniqueSVP, where the target point is
required to lie in the fundamental parallelepiped, and show how the previous
algorithm is able to solve these variants in subexponential time. Moreover, we
also show how the previous algorithm can be used to solve the BinaryLWE problem
with n samples in subexponential time . This
analysis does not require any heuristic assumption, contrary to other algebraic
approaches; instead, it uses a variant of an idea by Lyubashevsky to generate
many samples from a small number of samples. This makes it possible to
asymptotically and heuristically break the NTRU cryptosystem in subexponential
time (without contradicting its security assumption). We are also able to solve
subset sum problems in subexponential time for density , which is of
independent interest: for such density, the previous best algorithm requires
exponential time. As a direct application, we can solve in subexponential time
the parameters of a cryptosystem based on this problem proposed at TCC 2010.Comment: CRYPTO 201
Haptoglobin Phenotype, Preeclampsia Risk and the Efficacy of Vitamin C and E Supplementation to Prevent Preeclampsia in a Racially Diverse Population
Haptoglobin's (Hp) antioxidant and pro-angiogenic properties differ between the 1-1, 2-1, and 2-2 phenotypes. Hp phenotype affects cardiovascular disease risk and treatment response to antioxidant vitamins in some non-pregnant populations. We previously demonstrated that preeclampsia risk was doubled in white Hp 2-1 women, compared to Hp 1-1 women. Our objectives were to determine whether we could reproduce this finding in a larger cohort, and to determine whether Hp phenotype influences lack of efficacy of antioxidant vitamins in preventing preeclampsia and serious complications of pregnancy-associated hypertension (PAH). This is a secondary analysis of a randomized controlled trial in which 10,154 low-risk women received daily vitamin C and E, or placebo, from 9-16 weeks gestation until delivery. Hp phenotype was determined in the study prediction cohort (n = 2,393) and a case-control cohort (703 cases, 1,406 controls). The primary outcome was severe PAH, or mild or severe PAH with elevated liver enzymes, elevated serum creatinine, thrombocytopenia, eclampsia, fetal growth restriction, medically indicated preterm birth or perinatal death. Preeclampsia was a secondary outcome. Odds ratios were estimated by logistic regression. Sampling weights were used to reduce bias from an overrepresentation of women with preeclampsia or the primary outcome. There was no relationship between Hp phenotype and the primary outcome or preeclampsia in Hispanic, white/other or black women. Vitamin supplementation did not reduce the risk of the primary outcome or preeclampsia in women of any phenotype. Supplementation increased preeclampsia risk (odds ratio 3.30; 95% confidence interval 1.61-6.82, p<0.01) in Hispanic Hp 2-2 women. Hp phenotype does not influence preeclampsia risk, or identify a subset of women who may benefit from vitamin C and E supplementation to prevent preeclampsia
Scaling properties of protein family phylogenies
One of the classical questions in evolutionary biology is how evolutionary
processes are coupled at the gene and species level. With this motivation, we
compare the topological properties (mainly the depth scaling, as a
characterization of balance) of a large set of protein phylogenies with a set
of species phylogenies. The comparative analysis shows that both sets of
phylogenies share remarkably similar scaling behavior, suggesting the
universality of branching rules and of the evolutionary processes that drive
biological diversification from gene to species level. In order to explain such
generality, we propose a simple model which allows us to estimate the
proportion of evolvability/robustness needed to approximate the scaling
behavior observed in the phylogenies, highlighting the relevance of the
robustness of a biological system (species or protein) in the scaling
properties of the phylogenetic trees. Thus, the rules that govern the
incapability of a biological system to diversify are equally relevant both at
the gene and at the species level.Comment: Replaced with final published versio
Localized Giant Inflammatory Polyposis of the Ileocecum Associated with Crohn's Disease: Report of a Case
Although inflammatory polyposis is one of the common complications in patients with inflammatory bowel disease, it is rare that each poly grows up to more than 1.5 cm. We describe a case of localized giant inflammatory polyposis of the ileocecum associated with Crohn's disease. A 40-year-old man who had been followed for 28 years because of Crohn's disease was hospitalized for right lower abdominal pain after meals. Barium enema and colonoscopy showed numerous worm-like polyps in the ascending colon which grew up to the hepatic flexure of the colon from the ileocecum, causing an obstruction of the ileocecal orifice. Since histology of a biopsy specimen taken from the giant polyps showed no dysplasia, he was diagnosed with ileus due to the localized giant inflammatory polyposis. A laparoscopically assisted ileocecal resection was performed. The resected specimen showed that the giant polyps grew up into the ileocecum. Histological examination revealed inflammatory polyposis without neoplasm. Generally, conservative treatment is indicated for localized giant inflammatory polyposis because this lesion is regarded as benign. However, occasionally serious complications arise, requiring surgical treatment
A survey of assistive technologies and applications for blind users on mobile platforms: a review and foundation for research
This paper summarizes recent developments in audio and tactile
feedback based assistive technologies targeting the blind
community. Current technology allows applications to be
efficiently distributed and run on mobile and handheld
devices, even in cases where computational requirements are
significant. As a result, electronic travel aids, navigational
assistance modules, text-to-speech applications, as well as
virtual audio displays which combine audio with haptic
channels are becoming integrated into standard mobile devices.
This trend, combined with the appearance of increasingly user-
friendly interfaces and modes of interaction has opened a
variety of new perspectives for the rehabilitation and
training of users with visual impairments. The goal of this
paper is to provide an overview of these developments based on
recent advances in basic research and application development.
Using this overview as a foundation, an agenda is outlined for
future research in mobile interaction design with respect to
users with special needs, as well as ultimately in relation to
sensor-bridging applications in genera
Numerical Algebraic Geometry: A New Perspective on String and Gauge Theories
The interplay rich between algebraic geometry and string and gauge theories
has recently been immensely aided by advances in computational algebra.
However, these symbolic (Gr\"{o}bner) methods are severely limited by
algorithmic issues such as exponential space complexity and being highly
sequential. In this paper, we introduce a novel paradigm of numerical algebraic
geometry which in a plethora of situations overcomes these short-comings. Its
so-called 'embarrassing parallelizability' allows us to solve many problems and
extract physical information which elude the symbolic methods. We describe the
method and then use it to solve various problems arising from physics which
could not be otherwise solved.Comment: 36 page
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