Identifying risk factors involved in the common versus specific liabilities to substance use: A genetically informed approach

Individuals most often use several rather than one substance among alcohol, cigarettes or cannabis. This widespread co‐occurring use of multiple substances is thought to stem from a common liability that is partly genetic in origin. Genetic risk may indirectly contribute to a common liability to substance use through genetically influenced mental health vulnerabilities and individual traits. To test this possibility, we used polygenic scores indexing mental health and individual traits and examined their association with the common versus specific liabilities to substance use

Epigenetic profiling of ADHD symptoms trajectories: a prospective, methylome-wide study

Attention-deficit/hyperactivity disorder (ADHD) is a prevalent developmental disorder, associated with a range of long-term impairments. Variation in DNA methylation, an epigenetic mechanism, is implicated in both neurobiological functioning and psychiatric health. However, the potential role of DNA methylation in ADHD symptoms is currently unclear. In this study, we examined data from the Avon Longitudinal Study of Parents and Children (ALSPAC)-specifically the subsample forming the Accessible Resource for Integrated Epigenomics Studies (ARIES)-that includes (1) peripheral measures of DNA methylation (Illumina 450k) at birth (n=817, 49% male) and age 7 (n=892, 50% male) and (2) trajectories of ADHD symptoms (7-15 years). We first employed a genome-wide analysis to test whether DNA methylation at birth associates with later ADHD trajectories; and then followed up at age 7 to investigate the stability of associations across early childhood. We found that DNA methylation at birth differentiated ADHD trajectories across multiple genomic locations, including probes annotated to SKI (involved in neural tube development), ZNF544 (previously implicated in ADHD), ST3GAL3 (linked to intellectual disability) and PEX2 (related to perixosomal processes). None of these probes maintained an association with ADHD trajectories at age 7. Findings lend novel insights into the epigenetic landscape of ADHD symptoms, highlighting the potential importance of DNA methylation variation in genes related to neurodevelopmental and peroxisomal processes that play a key role in the maturation and stability of cortical circuits

The incidence of total hip arthroplasty after hip arthroscopy in osteoarthritic patients

<p>Abstract</p> <p>Objective</p> <p>To assess the incidence of total hip arthroplasty (THA) in osteoarthritic patients who were treated by arthroscopic debridement and to evaluate factors that might influence the time interval from the first hip arthroscopy to THA.</p> <p>Design</p> <p>Retrospective clinical series</p> <p>Methods</p> <p>Follow-up data and surgical reports were retrieved from 564 records of osteoarthritic patients that have had hip arthroscopy between the years 2002 to 2009 with a mean follow-up time of 3.2 years (range, 1-6.4 years). The time interval between the first hip arthroscopy to THA was modelled as a function of patient age; level of cartilage damage; procedures performed and repeated arthroscopies with the use of multivariate regression analysis.</p> <p>Results</p> <p>Ninety (16%) of all participants eventually required THA. The awaiting time from the first arthroscopy to a hip replacement was found to be longer in patients younger than 55 years and in a milder osteoarthritic stage. Patients that experienced repeated hip scopes had a longer time to THA than those with only a single procedure. Procedures performed concomitant with debridement and lavage did not affect the time interval to THA.</p> <p>Conclusions</p> <p>In our series of arthroscopic treatment of hip osteoarthritis, 16% required THA over a period of 7 years. Factors that influence the time to arthroplasty were age, degree of osteoarthritis and recurrent procedures.</p

Research opportunities for argumentation in social networks

Nowadays, many websites allow social networking between their users in an explicit or implicit way. In this work, we show how argumentation schemes theory can provide a valuable help to formalize and structure on-line discussions and user opinions in decision support and business oriented websites that held social networks between their users. Two real case studies are studied and analysed. Then, guidelines to enhance social decision support and recommendations with argumentation are provided.This work summarises results of the authors joint research, funded by an STMS of the Agreement Technologies COST Action 0801, by the Spanish government grants [CONSOLIDER-INGENIO 2010 CSD2007-00022, and TIN2012-36586-C03-01] and by the GVA project [PROMETEO 2008/051].Heras Barberá, SM.; Atkinson, KM.; Botti Navarro, VJ.; Grasso, F.; Julian Inglada, VJ.; Mcburney, PJ. (2013). Research opportunities for argumentation in social networks. 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In: Proceedings of the second international conference on computational models of argument (COMMA 2008), pp 116–127Chesñevar C, McGinnis J, Modgil S, Rahwan I, Reed C, Simari G, South M, Vreeswijk G, Willmott S (2006) Towards an argument interchange format. Knowl Eng Rev 21(4):293–316Chesñevar CI, Maguitman AG, Gonzàlez MP (2009) Empowering recommendation technologies through argumentation. Argumentation in artificial intelligence. Springer, Berlin, pp 403–422García AJ, Dix J, Simari GR (2009) Argument-based logic programming. Argumentation in artificial intelligence. Springer, BerlinGolbeck J (2006) Generating predictive movie recommendations from trust in social networks. In: Proceedings of the fourth international conference on trust management, LNCS, vol 3986, 93–104Gordon T, Prakken H, Walton D (2007) The Carneades model of argument and burden of proof. Artif Intell 171(10–15):875–896Guha R, Kumar R, Raghavan P, Tomkins A (2004) Propagating trust and distrust. In: Proceedings of the 13th international conference on, World Wide Web, pp 403–412Heras S, Navarro M, Botti V, Julián V (2009) Applying dialogue games to manage recommendation in social networks. In: Proceedings of the 6th international workshop on argumentation in multi-agent aystems, ArgMASHeras S, Atkinson K, Botti V, Grasso F, Julián V, McBurney P (2010a) How argumentation can enhance dialogues in social networks. In: Proceedings of the 3rd international conference on computational models of argument, COMMA, vol 216, pp 267–274Heras S, Atkinson K, Botti V, Grasso F, Julián V, McBurney P (2010b) Applying argumentation to enhance dialogues in social networks. In: ECAI 2010 workshop on computational models of natural argument, CMNA, pp 10–17Karacapilidis N, Tzagarakis M (2007) Web-based collaboration and decision making support: a multi-disciplinary approach. Web-Based Learn Teach Technol 2(4):12–23Kim D, Benbasat I (2003) Trust-related arguments in internet stores: a framework for evaluation. J Electron Commer Res 4(2):49–64Kim D, Benbasat I (2006) The effects of trust-assuring arguments on consumer trust in internet stores: application of Toulmin’s model of argumentation. Inf Syst Rese 17(3):286–300Laera L, Tamma V, Euzenat J, Bench-Capon T, Payne T (2006) Reaching agreement over ontology alignments. In: Proceedings of the 5th international semantic web conference (ISWC 2006)Lange C, Bojãrs U, Groza T, Breslin J, Handschuh S (2008) Expressing argumentative discussions in social media sites. In: Social data on the web (SDoW2008) workshop at the 7th international semantic web conferenceLinden G, Smith B, York J (2003) Amazon.com recommendations: item-to-item collaborative filtering. IEEE Internet Comput 7(1):76–80Linden G, Hong J, Stonebraker M, Guzdial M (2009) Recommendation algorithms, online privacy and more. Commun ACM, 52(5)Mika P (2007) Ontologies are us: a unified model of social networks and semantics. J Web Semant 5(1):5–15Montaner M, López B, de la Rosa JL (2002) Opinion-based filtering through trust. In: Cooperative information agents VI, LNCS, vol 2446, pp 127–144Ontañón S, Plaza E (2008) Argumentation-based information exchange in prediction markets. In: Proceedings of the 5th international workshop on argumentation in multi-agent systems, ArgMASPazzani MJ, Billsus D (2007) Content-based recommendation systems. In: The adaptive web, LNCS, vol 4321, pp 325–341Rahwan I, Zablith F, Reed C (2007) Laying the foundations for a world wide argument web. Artif Intell 171(10–15):897–921Rahwan I, Banihashemi B (2008) Arguments in OWL: a progress report. In: Proceedings of the 2nd international conference on computational models of argument (COMMA), pp 297–310Reed C, Walton D (2007) Argumentation schemes in dialogue. 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In: Proceedings of the first international conference on agreement technologie

Argument mining: A machine learning perspective

Argument mining has recently become a hot topic, attracting the interests of several and diverse research communities, ranging from artificial intelligence, to computational linguistics, natural language processing, social and philosophical sciences. In this paper, we attempt to describe the problems and challenges of argument mining from a machine learning angle. In particular, we advocate that machine learning techniques so far have been under-exploited, and that a more proper standardization of the problem, also with regards to the underlying argument model, could provide a crucial element to develop better systems

Persistence of magnetic field driven by relativistic electrons in a plasma

The onset and evolution of magnetic fields in laboratory and astrophysical plasmas is determined by several mechanisms, including instabilities, dynamo effects and ultra-high energy particle flows through gas, plasma and interstellar-media. These processes are relevant over a wide range of conditions, from cosmic ray acceleration and gamma ray bursts to nuclear fusion in stars. The disparate temporal and spatial scales where each operates can be reconciled by scaling parameters that enable to recreate astrophysical conditions in the laboratory. Here we unveil a new mechanism by which the flow of ultra-energetic particles can strongly magnetize the boundary between the plasma and the non-ionized gas to magnetic fields up to 10-100 Tesla (micro Tesla in astrophysical conditions). The physics is observed from the first time-resolved large scale magnetic field measurements obtained in a laser wakefield accelerator. Particle-in-cell simulations capturing the global plasma and field dynamics over the full plasma length confirm the experimental measurements. These results open new paths for the exploration and modelling of ultra high energy particle driven magnetic field generation in the laboratory

Air pollution, ethnicity and telomere length in east London schoolchildren: An observational study

This study was funded/supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London, Dr. and Mrs. Lee Iu Cheung Fund, and Hackney Primary Care Trust (PCT)

Effects of air pollution and the introduction of the London Low Emission Zone on the prevalence of respiratory and allergic symptoms in schoolchildren in East London: a sequential cross-sectional study

The adverse effects of traffic-related air pollution on children’s respiratory health have been widely reported, but few studies have evaluated the impact of traffic-control policies designed to reduce urban air pollution. We assessed associations between traffic-related air pollutants and respiratory/allergic symptoms amongst 8–9 year-old schoolchildren living within the London Low Emission Zone (LEZ). Information on respiratory/allergic symptoms was obtained using a parent-completed questionnaire and linked to modelled annual air pollutant concentrations based on the residential address of each child, using a multivariable mixed effects logistic regression analysis. Exposure to traffic-related air pollutants was associated with current rhinitis: NOx (OR 1.01, 95% CI 1.00–1.02), NO2 (1.03, 1.00–1.06), PM10 (1.16, 1.04–1.28) and PM2.5 (1.38, 1.08–1.78), all per μg/m3 of pollutant, but not with other respiratory/allergic symptoms. The LEZ did not reduce ambient air pollution levels, or affect the prevalence of respiratory/allergic symptoms over the period studied. These data confirm the previous association between traffic-related air pollutant exposures and symptoms of current rhinitis. Importantly, the London LEZ has not significantly improved air quality within the city, or the respiratory health of the resident population in its first three years of operation. This highlights the need for more robust measures to reduce traffic emissions

Bilateral rectus femoris intramuscular haematoma following simultaneous quadriceps strain in an athlete: a case report

<p>Abstract</p> <p>Introduction</p> <p>Bilateral rectus femoris haematoma following a simultaneous strain of the quadriceps muscles is a very rare condition.</p> <p>Case presentation</p> <p>We report the case of a 21-year-old Greek Caucasian female rowing athlete who was injured on both thighs. She complained of pain and inability to walk. Physical examination revealed tenderness over the thighs and restriction of knee movement. The result of a roentgenogram was normal, and there was no evidence of fracture or patella displacement. Magnetic resonance imaging revealed haematoma formation in both the rectus femoris muscles. The diameters of the left and right haematomas within the muscles were 6 cm and 5 cm, respectively. Therapeutic approaches included compression bandages, ice application, rest, elevation, and administration of muscle relaxant drugs. Active stretching and isometric exercises were performed after three days. The patient was able to walk using crutches two days after the initiation of treatment. On the seventh day, she had regained her full ability to walk without crutches. Non-steroidal anti-inflammatory drugs were administered on the fifth day and continued for one week. Six weeks later, she had pain-free function and the result of magnetic resonance imaging was normal. She was able to resume her training programme and two weeks later, she returned to her previous sport activities and competitions.</p> <p>Conclusion</p> <p>There are references in the literature regarding the occurrence of unilateral quadriceps haematomas following strain and bilateral quadriceps tendon rupture in athletes. Simultaneous bilateral rectus femoris haematomas after a muscle strain is a rare condition. It must be diagnosed early. The three phases of treatment are rest, knee mobilization, and restoration of quadriceps function.</p