Muros de escollera en urbanizaciones

The uneven and slopes terrain force us to intervene with rigid or flexible containment structures. Containment structures tend to be mostly of reinforced concrete or steel sheet piling. For some time, the use of stone jetties as containment structures and permanent stabilization in housing estates is being imposed. This type of structure has been used successfully in slopes of roads and jetties on port. When moving it to suburbia has disparaged some aspects, both design and calculation, not taking into account actions in risk areas, or eliminating essential components as filters and drain components. This document analyzes the work of intervention in two works affected in Motril (Granada, Spain) and Almeria (Spain), where the breakwaters were utilized, reaching recidivism in one of them. Guide for the design and construction of breakwaters in roadworks from the Ministry of Public Works in 1998, revised in 2006, [3] is a valuable document but requires a Decalogue of specific instructions for use in works of urbanization, in general of lower volume, and with the largest number of meetings of surfaces. Three-dimensionality is usually an important factor to take into account.Los desniveles y pendientes del terreno nos obligan a intervenir mediante estructuras de contención, rígidas o flexibles. Las estructuras de contención suelen ser en su mayor parte de hormigón armado o tablestacas metálicas. Desde hace algún tiempo se está imponiendo la utilización de escolleras de piedra como estructuras de contención y estabilización permanentes en urbanizaciones. Este tipo de estructuras ya habían sido usadas con éxito en taludes de carreteras y espigones de puerto. Al trasladarse a las urbanizaciones se ha menospreciado algunos aspectos, tanto de diseño y cálculo, no teniendo en cuenta las acciones sísmicas en zonas de riesgo como Motril, o eliminando componentes esenciales como filtros y drenajes. El presente documento analiza los trabajos de intervención realizados en dos obras siniestradas en Motril y Almería (España), donde se utilizaron las escolleras, uno de ellos incluso reincidente. La Guía para el diseño y construcción de escolleras en obras de carreteras del Ministerio de Fomento de 1998, revisada en 2006, es un valioso documento pero precisa de un decálogo de instrucciones precisas para su uso en obras de urbanización, en general de menor volumen, y con mayor número de encuentros de superficies. La tridimensionalidad suele ser un factor importante a tener en cuenta

Desarrollo de un composite ácido cáprico/ácido mirístico/soporte poroso para el almacenamiento de energía térmica

CIES2020 - XVII Congresso Ibérico e XIII Congresso Ibero-americano de Energia SolarRESUMEN: Un composite constituido del eutéctico binario ácido cáprico/ácido mirístico (CA:MA) y un soporte mineral poroso colombiano fue desarrollado para aplicaciones de almacenamiento de energía térmica alrededor de los 26 °C. Diferentes porcentajes de impregnación de CA:MA (25%, 35% y 40%) en el soporte fueron estudiados para determinar los valores óptimos en términos de filtración. El mejor composite obtenido, con el 35% de CA:MA y menos del 1,5% de filtración, fue caracterizado térmicamente mediante calorimetría diferencial de barrido (DSC), así mismo, se evaluaron su conductividad térmica, capacidad calorífica y estabilidad térmica a través de las técnicas del hilo caliente, calorimetría diferencial de barrido modulada (MDSC) y ciclado térmico, respectivamente.ABSTRACT: A composite consisting of the binary eutectic capric acid/myristic acid (CA:MA) and a Colombian porous mineral support was developed for thermal energy storage applications around 26 °C. Different percentages of CA:MA impregnation (25%, 35% and 40%) in the support were studied to determine the optimal values in terms of leakage. The best composite obtained, with 35% CA:MA and less than 1.5% of leakage, was thermally characterized by differential scanning calorimetry (DSC). Besides, its thermal conductivity, heat capacity and thermal stability were evaluated through the techniques of hot wire, modulated differential scanning calorimetry (MDSC) and thermal cycling, respectively.info:eu-repo/semantics/publishedVersio

Dietary carbohydrate intake, visceral adipose tissue and associated markers of cardiometabolic risk

Risk of cardiometabolic (CM) disease is characterised by elevated visceral adipose tissue (VAT) and a number of associated biomar- kers(1). Some dietary carbohydrates (CHO) have been found to contribute to VAT accumulation(2). Little is known about the impact of following a low-carbohydrate diet versus a high-carbohydrate diet on VAT, adiponectin (ADPN), leptin (LEPT) and leptin:adipo- nectin ratio (LAR). The aim of this investigation was to assess the impact of dietary carbohydrates (CHO) on VAT and emerging CM risk markers in a sample of 10 healthy normal-weight and overweight Caucasian adults aged 32–60 (80 % male) at increased CM risk(3). This pilot study received ethical approval from Liverpool John Moores University Research Ethics Committee (16/ELS/ 029) and was registered with ClinicalTrials.gov (Ref. NCT03257085). Participants were randomly allocated to one of two groups and asked to either consume 50 % energy from CHO (high-carb (HC)) for a duration of 8 weeks. VAT was ana- lysed via bioelectrical impedance (SECA mBCA 515). Blood plasma samples were collected at baseline (BL), interim point (IP) and endpoint (EP) after a 12-hour overnight fast, immediately processed and frozen at -80°C. Thawed plasma samples were analysed via immunoassay technology (Randox Evidence InvestigatorTM Metabolic Syndrome Arrays I and II) for ADPN and LEPT levels. Statistical analysis was undertaken using IBM SPSS 24®. Parametric data was analysed via two-way mixed ANOVA; non-parametric data was analysed via Mann-Whitney U test and Friedman test. Average daily carbohydrate intake in the LC group was 44·2 g at IP and 48·9 g at EP. There were no significant differences between groups at any time point for ADPN, LEPT, LAR or VAT and no significant inter- actions for time or group*time for ADPN, LEPT or LAR. However, in the LC group VAT decreased significantly between baseline and endpoint by 15 % (p = ·015) Over the course of the intervention ADPN and LEPT decreased non- significantly (by 4 % and 70 % respectively) in the LC group, whilst increasing non-significantly in the HC group (9 % and 65 % respectively). LAR increased in the HC group throughout the study, whilst LAR in the LC group decreased albeit not significantly. VAT (litre) ADPN (ng/mL) LEPT (ng/mL) LAR BL IP EP Median Median Median M SD M SD M SD BL IP EP BL IP EP BL IP EP LC 4·1a 1·2 3·8 1·3 3·5a 1·2 8·9 8·6 8·5 3·96 1·64 1·20 0·45 0·19 0·14 HC 2·7 0·1 1·6 0·3 2·5 0·1 11·3 13·4 12·3 0·97 1·1 1·60 0·07 0·07 0·46 ADPN = adiponectin, BL = baseline, EP = endpoint, HC = high-carbohydrate, moderate fat diet, IP = interim point, LAR = leptin:adiponectin ratio, LEPT = leptin, LC = low-carbohydrate, high-fat diet, VAT = visceral adipose tissue, ap = ·015. NB: interquartile ranges not provided for median values due to missing data. Higher LAR has been found to be a marker of increased CM risk(4). In conclusion, while the significant reduction in VAT in the LC group corresponds with the reduction of LAR further evidence is required to corroborate these findings. Previous evidence for LC is supportive for improved CM health from various biomarkers(5); LAR should be considered as a useful endocrine addition for future LC studies. 1. Krasimira A, Mozaffarian D & Pischon T (2018) Clin Chem 64, 142–153. 2. Rüttgers D, Fischer K, Koch M et al. (2015) Br J Nutr 114, 1929–1940. 3. Jebb S, Lovegrove J, Griffin B et al. (2010) Am J Clin Nutr 92, 748–58. 4. López-Jaramillo P, Gómez-Arbeláez D, López-López J et al. (2014) Horm Mol Biol Clin Investig 18, 37–45. 5. Bazzano L, Hi T, Reynolds K et al. (2014) Ann Intern Med 161, 309–318

Dietary protein intake and all-cause and cause-specific mortality: results from the Rotterdam Study and a meta-analysis of prospective cohort studies

Evidence for associations between long-term protein intake with mortality is not consistent. We aimed to examine associations of dietary protein from different s

Twenty years of global surveillance of antituberculosis-drug resistance

Antimicrobial resistance represents a major threat to global health and security. In 2014, the World Health Assembly called on all nations and the international community to take every necessary measure to control it, including surveillance of its emergence and spread.1 The development of drug resistance in Mycobacterium tuberculosis was first documented in the late 1940s, soon after antibiotic therapy was introduced for tuberculosis treatment.2 It quickly became obvious that combination chemotherapy could prevent the emergence of drug resistance3 and that patients infected with drug-resistant strains were less likely to be cured.4 Nevertheless, it was only in the early 1990s that drugresistant tuberculosis began to receive global attention as a public health threat. This coincided with the detection of outbreaks of multidrugresistant (MDR) tuberculosis (defined as resistance to at least rifampin and isoniazid) that were associated with high mortality among patients coinfected with the human immunodeficiency virus (HIV).5-8 The urgent need for a global mechanism to monitor the emergence and spread of resistance to antituberculosis drugs became clear. In 1994, the Global Tuberculosis Program of the World Health Organization (WHO), with the support of the International Union against Tuberculosis and Lung Disease (the Union), established the Global Project on Anti-Tuberculosis Drug Resistance Surveillance (hereafter referred to as \u201cthe project\u201d) to measure the magnitude of drug resistance and to monitor trends. This project remains the oldest and largest initiative on the surveillance of antimicrobial resistance in the world.9 In this article, we describe the history of global surveillance of drug resistance in tuberculosis and discuss methods for surveillance, the quality of available data, the key achievements and findings to date, the main challenges that remain, and future directions

Bacterial strains from floodplain soils perform different plant-growth promoting processes and enhance cowpea growth

ABSTRACT Certain nodulating nitrogen-fixing bacteria in legumes and other nodule endophytes perform different plant-growth promoting processes. The objective of this study was to evaluate 26 bacterial strains isolated from cowpea nodules grown in floodplain soils in the Brazilian savannas, regarding performance of plant-growth promoting processes and ability to enhance cowpea growth. We also identified these strains by 16S rRNA sequencing. The following processes were evaluated: free-living biological nitrogen fixation (BNF), solubilization of calcium, aluminum and iron phosphates and production of indole-3-acetic acid (IAA). The abilities to nodulate and promote cowpea growth were evaluated in Leonard jars. Partial sequencing of the 16S rRNA gene identified 60 % of the strains as belonging to genus Paenibacillus. The following four genera were also identified: Bacillus, Bradyrhizobium, Enterobacter and Pseudomonas. None of the strains fixed N2 free-living. Among the strains, 80 % solubilized Ca phosphate and one solubilized Al phosphate and none solubilized Fe phosphate. The highest IAA concentrations (52.37, 51.52 and 51.00 μg mL−1) were obtained in the 79 medium with tryptophan by Enterobacter strains UFPI B5-7A, UFPI B5-4 and UFPI B5-6, respectively. Only eight strains nodulated cowpea, however, all increased production of total dry matter. The fact that the strains evaluated perform different biological processes to promote plant growth indicates that these strains have potential use in agricultural crops to increase production and environmental sustainability

The sterols isolated from evening primrose oil inhibit human colon adenocarcinoma cell proliferation and induce cell cycle arrest through upregulation of LXR

© 2014 Elsevier Ltd. Evening primrose oil (EPO) is widely used as a dietary supplement from which beneficial effects have been reported in rheumatic and arthritic conditions, atopic dermatitis, psoriasis, premenstrual and menopausal syndrome, and diabetic neuropathy. The aim of this study was to determine whether phytosterols isolated from evening primrose oil (PS-EPO), and its main components β-sitosterol and campesterol, affect proliferation, cell death, and the cell cycle of human colon adenocarcinoma (HT-29) cells. PS-EPO were a potent antiproliferative agents in a dose- and time-dependent manner, with an IC50 of 62.9 μg/mL after 48 h, lower than β-sitosterol and campesterol (79.0 μM and 71.6 μM respectively). Flow cytometry showed that PS-EPO exerted a stimulatory effect on apoptosis and necrosis, increasing the number of cells in G0/G1 phase. PS-EPO produced a significant upregulation in liver X receptor (LXR) gene expression that may be one of the principal mechanisms of the tumor shrinkage by PS-EPO.Peer Reviewe

Consenso colombiano de atención, diagnóstico y manejo de la infección por SARS-COV-2/COVID-19 en establecimientos de atención de la salud Recomendaciones basadas en consenso de expertos e informadas en la evidencia

The “Asociación Colombiana de Infectología” (ACIN) and the “Instituto de Evaluación de Nuevas Tecnologías de la Salud” (IETS) created a task force to develop recommendations for Covid 19 health care diagnosis, management and treatment informed, and based, on evidence. Theses reccomendations are addressed to the health personnel on the Colombian context of health services. © 2020 Asociacion Colombiana de Infectologia. All rights reserved