Pursuing a net-zero carbon future for all: Challenges for commercial real estate

The commercial real-estate industry faces both opportunities and challenges in reaching net-zero carbon goals. Successful low-carbon strategies rely on organizational decision-making, including cooperation between diverse groups of stakeholders. Not all landlords and tenants are equal, so a key challenge will be activating change across the industry as a whole

Crafting sustainability in iconic skyscrapers: a system of building professions in transition?

This paper focuses on coordination, fragmentation, and the potential for transition in the system of building professions in the American construction industry. The paper relies mainly on local press coverage of three iconic New York skyscrapers—the Empire State Building (completed in 1931), the U.N. Secretariat (completed in 1952) and One World Trade Center (completed in 2014)— to compare how the roles of different building professionals are seen by and portrayed to the public eye over time. The historic cases show how different professional groups—builders in the 1930s, architects in the 1950s, and engineers in the 2010s—imbued each project with “sustainable” qualities appropriate for its time. Using a system of professions (Abbott 1988[r]) approach, the paper describes and discusses the implications of changes in societal interest from doing to designing in American skyscrapers. The paper concludes by arguing that greater coordination between doers and designers in the construction industry, of the kind exhibited in the early days of skyscrapers, would enable the social production of sustainable buildings. For this to happen, however, society would need to place a higher value on tangible outcomes compared to lofty goals..

Determination of Abundant Metabolite Matrix Adducts Illuminates the Dark Metabolome of MALDI-Mass Spectrometry Imaging Datasets

: Spatial metabolomics using mass spectrometry imaging (MSI) is a powerful tool to map hundreds to thousands of metabolites in biological systems. One major challenge in MSI is the annotation of m/z values, which is substantially complicated by background ions introduced throughout the chemicals and equipment used during experimental procedures. Among many factors, the formation of adducts with sodium or potassium ions, or in case of matrix-assisted laser desorption ionization (MALDI)- MSI, the presence of abundant matrix clusters strongly increases total m/z peak counts. Currently, there is a limitation to identify the chemistry of the many unknown peaks to interpret their biological function. We took advantage of the co-localization of adducts with their parent ions and the accuracy of high mass resolution to estimate adduct abundance in 20 datasets from different vendors of mass spectrometers. Metabolites ranging from lipids to amines and amino acids form matrix adducts with the commonly used 2,5-dihydroxybenzoic acid (DHB) matrix like [M + (DHB-H2O) + H]+ and [M + DHB + Na]+ . Current data analyses neglect those matrix adducts and overestimate total metabolite numbers, thereby expanding the number of unidentified peaks. Our study demonstrates that MALDI-MSI data are strongly influenced by adduct formation across different sample types and vendor platforms and reveals a major influence of so far unrecognized metabolite−matrix adducts on total peak counts (up to one third). We developed a software package, mass2adduct, for the community for an automated putative assignment and quantification of metabolite−matrix adducts enabling users to ultimately focus on the biologically relevant portion of the MSI data

Beyond feedback: introducing the 'engagement gap' in organizational energy management

This paper discusses socio-technical relationships between people, organizations and energy in workplaces. Inspired by Sherry Arnstein’s ladder of citizen participation, it explores widening energy management beyond energy managers to other employees, introducing the idea of an ‘engagement gap’ to support a move beyond unidirectional forms of engagement (e.g. feedback and nudging) to more socially interactive processes. Results are drawn from two projects researching energy practices in public authorities and retail organizations. The first project, ‘GoodDeeds’, collaboratively created an information and communication technology tool and explored participatory processes within a municipality. The second project, Working with Infrastructure, Creation of Knowledge, and Energy strategy Development (WICKED), explored energy management in retail companies. The paper uses a ‘4Cs’ framework to articulate the influences of concerns, capacities and technical conditions within organizational communities. The results concur with previous research that energy management sits against a backdrop of competing organizational, institutional and political concerns. New data reveal discrepancies across organizations with regard to energy management capacities and technical metering conditions. The authors suggest employee engagement can be broadened by treating energy as a communal subject for discussion, negotiation and partnership. This objective moves beyond the ‘information-deficit’ approach intrinsic in the existing focus on analytics, dashboards and feedback

The middle-out perspective:an approach to formalise 'normal practice' in public health advocacy

AIMS: The middle-out perspective (MOP) provides a lens to examine how actors positioned between government (top) and individuals (bottom) act to promote broader societal changes from the middle-out (rather than the top-down or bottom-up). The MOP has been used in recent years in the fields of energy, climate change, and development studies. We argue that public health practitioners involved with advocacy activities and creating alliances to amplify health promotion actions will be familiar with the general MOP concept if not the formal name. The article aims to demonstrate this argument. METHODS: This article introduces the MOP conceptual framework and customises it for a public health audience by positioning it among existing concepts and theories for actions within public health. Using two UK case studies (increasing signalised crossing times for pedestrians and the campaign for smoke-free legislation), we illustrate who middle actors are and what they can do to result in better public health outcomes. RESULTS: These case studies show that involving a wider range of middle actors, including those not traditionally involved in improving the public's health, can broaden the range and reach of organisations and individuals involving in advocating for public health measures. They also demonstrate that middle actors are not neutral. They can be recruited to improve public health outcomes, but they may also be exploited by commercial interests to block healthy policies or even promote a health-diminishing agenda. CONCLUSION: Using the MOP as a formal approach can help public health organisations and practitioners consider potential 'allies' from outside traditional health-related bodies or professions. Formal mapping can expand the range of who are considered potential middle actors for a particular public health issue. By applying the MOP, public health organisations and staff can enlist the additional leverage that is brought to bear by involving additional middle actors in improving the public's health

Effect of Off-Body Laser Discharge on Drag Reduction of Hemisphere Cylinder in Supersonic Flow-Part II

The interaction of on-axis and o -axis laser discharge in front of a hemisphere cylinder in Mach 2.0 ow is investigated numerically. Details of the physics of the interaction of the laser-induced shock and the heated region with the bow shock and its e ect on drag reduction are included. The energetic eciency of the laser discharge in reducing drag is calculated

How Patients\u27 Self-Disclosure about Sickle Cell Pain Episodes to Significant Others Relates to Living with Sickle Cell Disease

Objectives: This cross-sectional study examines to whom and how fully sickle cell disease (SCD) patients talk to others about sickle cell pain, how helpful it is to talk with others about these pain episodes, and the association between talking to others about sickle cell pain episodes and patients\u27 psychological adjustment and coping strategies in managing the disease. Methods: A convenience sample of 73 African American patients with SCD (30 men and 43 women), were recruited from two SCD clinics at the time of routine medical visits. Most participants had been diagnosed with hemoglobin SS, and they reported an average number of 8.61 pain episodes in the previous 12 months. Participants were asked to whom, how fully, and how helpful it was to talk to significant others about SCD pain episodes experienced in the last 12 months. Patients also completed measures of their psychological adjustment as well as how they would manage a future sickle cell pain episode. Self-report ratings were made on Likert-type scales. Results: Based on paired samples t-tests, participants talked significantly more fully about their thoughts and feelings concerning pain episodes to God and to their primary medical providers than to either their parents, siblings, or an intimate partner/close friend. Bivariate correlations indicated that amount and helpfulness of talking about pain episodes to God and to parents were significantly associated with better psychological adjustment on selected measures. Also, bivariate correlations indicated that helpfulness in talking with siblings, intimate partner/close friend, and primary medical providers was positively related with willingness to go to a physician in the event of a future pain episode. Conclusions: The results document to whom and how helpful it is to talk with others about SCD pain episodes and how SCD disclosure is related to strategies for managing this disease

Development and evaluation of a high-throughput, low-cost genotyping platform based on oligonucleotide microarrays in rice

<p>Abstract</p> <p>Background</p> <p>We report the development of a microarray platform for rapid and cost-effective genetic mapping, and its evaluation using rice as a model. In contrast to methods employing whole-genome tiling microarrays for genotyping, our method is based on low-cost spotted microarray production, focusing only on known polymorphic features.</p> <p>Results</p> <p>We have produced a genotyping microarray for rice, comprising 880 single feature polymorphism (SFP) elements derived from insertions/deletions identified by aligning genomic sequences of the <it>japonica </it>cultivar Nipponbare and the <it>indica </it>cultivar 93-11. The SFPs were experimentally verified by hybridization with labeled genomic DNA prepared from the two cultivars. Using the genotyping microarrays, we found high levels of polymorphism across diverse rice accessions, and were able to classify all five subpopulations of rice with high bootstrap support. The microarrays were used for mapping of a gene conferring resistance to <it>Magnaporthe grisea</it>, the causative organism of rice blast disease, by quantitative genotyping of samples from a recombinant inbred line population pooled by phenotype.</p> <p>Conclusion</p> <p>We anticipate this microarray-based genotyping platform, based on its low cost-per-sample, to be particularly useful in applications requiring whole-genome molecular marker coverage across large numbers of individuals.</p

Glucosyltransferase phase variation in Streptococcus gordonii modifies adhesion to saliva-coated hydroxyapatite surfaces in a sucrose-independent manner

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72317/1/j.1399-302X.1992.tb00521.x.pd