Developing facilitation skills amongst undergraduate nursing students to promote dementia awareness with children in a higher education institution (innovative practice)

Final year students on a BSc Hons Nursing programme in Scotland were supported to become Dementia Friends facilitators and develop interactive dementia awareness sessions for children from local schools. The children were invited to indicate phrases and images they associated with ‘dementia’ at the outset and end of the session. Analysis of the responses suggested that there were positive changes in the children’s values and beliefs when thinking about a person living with dementia during the sessions. We suggest that peer learning is a valuable strategy to increase public and professional awareness about dementia and supports the development of graduate attributes.</p

Abciximab for thrombolysis during intracranial aneurysm coiling

Introduction: Thrombotic events are a common and severe complication of endovascular aneurysm treatment with significant impact on patients' outcome. This study evaluates risk factors for thrombus formation and assesses the efficacy and safety of abciximab for clot dissolution. Materials and methods: All patients treated with abciximab during (41 patients) or shortly after (22 patients) intracranial aneurysm coil embolisation were retrieved from the institutional database (2000 to 2007, 1,250 patients). Sixty-three patients (mean age, 55.3years, ±12.8) had received either intra-arterial or intravenous abciximab. Risk factors for clot formation were assessed and the angiographic and clinical outcome evaluated. Results: No aneurysm rupture occurred during or after abciximab application. The intra-procedural rate of total recanalisation was 68.3%. Thromboembolic complications were frequently found in aneurysms of the Acom complex and of the basilar artery, whilst internal carotid artery aneurysms were underrepresented. Two patients died of treatment-related intracranial haemorrhages into preexisting cerebral infarcts. Two patients developed a symptomatic groin haematoma. Conclusions: Abciximab is efficacious and safe for thrombolysis during and after endovascular intracranial aneurysm treatment in the absence of preexisting ischaemic strok

Overview of Instrument Response Calibrations

The Instrument Response Calibration (IRC) constitutes a fundamental part of the Aeolus processing chain and the basis for accurate and precise wind information provided to the global user community. The IRC is a crucial instrument mode for the wind measurement and has, hence, been extensively investigated with the ALADIN Airborne Demonstrator already before launch of the Aeolus satellite. IRCs are used to determine the relationship between the Doppler frequency shift on the backscattered light, i.e. the wind speed, and the frequency response of the Rayleigh and Mie spectrometers. This is achieved by sampling a frequency range of 1 GHz in steps of 25 MHz around the nominal laser frequency for the wind measurement. Whereas Aeolus wind measurements (WVM) are obtained under an off-nadir viewing angle of 35°, IRCs are performed in nadir viewing mode, thereby trying to avoid the atmospheric horizontal wind component along the line-of-sight as well as the component of the satellite velocity. The special importance of the IRC mode has changed with time caused by the experiences gained after the launch of Aeolus

Perceptions of HIV cure and willingness to participate in HIV cure-related trials among people enrolled in the Netherlands cohort study on acute HIV infection

BACKGROUND: People who initiate antiretroviral therapy (ART) during acute HIV infection are potential candidates for HIV cure-related clinical trials, as early ART reduces the size of the HIV reservoir. These trials, which may include ART interruption (ATI), might involve potential risks. We explored knowledge and perception of HIV cure and willingness to participate in cure-related trials among participants of the Netherlands Cohort Study on Acute HIV infection (NOVA study), who started antiretroviral therapy immediately after diagnosis of acute HIV infection. METHODS: We conducted 20 in-depth qualitative interviews with NOVA study participants between October–December 2018. Data were analyzed thematically, using inductive and iterative coding techniques. FINDINGS: Most participants had limited knowledge of HIV cure and understood HIV cure as complete eradication of HIV from their bodies. HIV cure was considered important to most participants, mostly due to the stigma surrounding HIV. More than half would consider undergoing brief ATI during trial participation, but only one person considered extended ATI. Viral rebound and increased infectiousness during ATI were perceived as large concerns. Participants remained hopeful of being cured during trial participation, even though they were informed that no personal medical benefit was to be expected. INTERPRETATION: Our results highlight the need for thorough informed consent procedures with assessment of comprehension and exploration of personal motives prior to enrollment in cure-related trials. Researchers might need to moderate their expectations about how many participants will enroll in a trial with extended ATI

NWP calibration applied to Aeolus Mie channel winds

Aeolus is the first Doppler wind lidar (DWL) to measure wind profiles from space. Aeolus is an ESA (European Space Agency) explorer mission with the objective to retrieve winds from the collected atmospheric return signal which is the result of Mie and Rayleigh scattering of laser-emitted light by atmospheric molecules and particulates. The focus of this paper is on winds retrieved from instrument Mie channel collected data, that is, originating from Mie scattering by atmospheric aerosols and clouds. The use of simulated data from numerical weather prediction (NWP) models is a widely accepted and proven concept for the monitoring of the performance of many meteorological instruments, including Aeolus. Continuous monitoring of Aeolus Mie channel winds against model winds from the European Centre for Medium-Range Weather Forecasts (ECMWF) has revealed systematic errors in retrieved Mie winds. Following a reverse engineering approach, the systematic errors could be traced back to imperfections of the data in the calibration tables which serve as input for the on-ground wind processing algorithms. A new algorithm, denoted NWP calibration, makes use of NWP model winds to generate an updated calibration table. It is shown that Mie winds retrieved by making use of the NWP-based calibration tables show reduced systematic errors, not only when compared to NWP model winds but also when compared to an independent dataset of very-high-resolution aircraft wind data. The latter gives high confidence that the NWP-based calibration algorithm does not introduce model-related errors into retrieved Aeolus Mie winds. Based on the presented results in this paper, the NWP-based calibration table, as part of the level-2B wind processing, has become part of the operational processing chain since 01 July 2021

Shaping the development of the UKCEH UK-SCAPE Data Science Framework. Workshop report

UKCEH held an event to share progress on the development of the UK-SCAPE Data Science Framework (DSF), explore community expectations for the DSF and get feedback from the participants on whether the DSF will meet their needs. Participants were able to offer feedback through interactive voting sessions, breakout groups and a feedback form

The translation research in a dental setting (TRiaDS) programme protocol

Background: It is well documented that the translation of knowledge into clinical practice is a slow and haphazard process. This is no less true for dental healthcare than other types of healthcare. One common policy strategy to help promote knowledge translation is the production of clinical guidance, but it has been demonstrated that the simple publication of guidance is unlikely to optimise practice. Additional knowledge translation interventions have been shown to be effective, but effectiveness varies and much of this variation is unexplained. The need for researchers to move beyond single studies to develop a generalisable, theory based, knowledge translation framework has been identified.For dentistry in Scotland, the production of clinical guidance is the responsibility of the Scottish Dental Clinical Effectiveness Programme (SDCEP). TRiaDS (Translation Research in a Dental Setting) is a multidisciplinary research collaboration, embedded within the SDCEP guidance development process, which aims to establish a practical evaluative framework for the translation of guidance and to conduct and evaluate a programme of integrated, multi-disciplinary research to enhance the science of knowledge translation.Methods: Set in General Dental Practice the TRiaDS programmatic evaluation employs a standardised process using optimal methods and theory. For each SDCEP guidance document a diagnostic analysis is undertaken alongside the guidance development process. Information is gathered about current dental care activities. Key recommendations and their required behaviours are identified and prioritised. Stakeholder questionnaires and interviews are used to identify and elicit salient beliefs regarding potential barriers and enablers towards the key recommendations and behaviours. Where possible routinely collected data are used to measure compliance with the guidance and to inform decisions about whether a knowledge translation intervention is required. Interventions are theory based and informed by evidence gathered during the diagnostic phase and by prior published evidence. They are evaluated using a range of experimental and quasi-experimental study designs, and data collection continues beyond the end of the intervention to investigate the sustainability of an intervention effect.Discussion: The TRiaDS programmatic approach is a significant step forward towards the development of a practical, generalisable framework for knowledge translation research. The multidisciplinary composition of the TRiaDS team enables consideration of the individual, organisational and system determinants of professional behaviour change. In addition the embedding of TRiaDS within a national programme of guidance development offers a unique opportunity to inform and influence the guidance development process, and enables TRiaDS to inform dental services practitioners, policy makers and patients on how best to translate national recommendations into routine clinical activities

ESA's Space-based Doppler Wind Lidar Mission Aeolus - First Wind and Aerosol Product Assessment Results

The European Space Agency (ESA) wind mission, Aeolus, hosts the first space-based Doppler Wind Lidar (DWL) world-wide. The primary mission objective is to demonstrate the DWL technique for measuring wind profiles from space, intended for assimilation in Numerical Weather Prediction (NWP) models. The wind observations will also be used to advance atmospheric dynamics research and for evaluation of climate models. Mission spinoff products are profiles of cloud and aerosol optical properties. Aeolus was launched on 22 August 2018, and the Atmospheric LAser Doppler INstrument (Aladin) instrument switch-on was completed with first high energy output in wind mode on 4 September 2018. The on-ground data processing facility worked excellent, allowing L2 product output in near-real-time from the start of the mission. First results from the wind profile product (L2B) assessment show that the winds are of very high quality, with random errors in the free Troposphere within (cloud/aerosol backscatter winds: 2.1 m/s) and larger (molecular backscatter winds: 4.3 m/s) than the requirements (2.5 m/s), but still allowing significant positive impact in first preliminary NWP impact experiments. The higher than expected random errors at the time of writing are amongst others due to a lower instrument outand input photon budget than designed. The instrument calibration is working well, and some of the data processing steps are currently being refined to allow to fully correct instrument alignment related drifts and elevated detector dark currents causing biases in the first data product version. The optical properties spin-off product (L2A) is being compared e.g. to NWP model clouds, air quality model forecasts, and collocated ground-based observations. Features including optically thick and thin particle and hydrometeor layers are clearly identified and are being validated

Data quality of Aeolus wind measurements

The European Space Agency (ESA)'s Earth Explorer Aeolus was launched in August 2018 carrying the world's first spaceborne wind lidar, the Atmospheric Laser Doppler Instrument (ALADIN). ALADIN uses a high spectral resolution Doppler wind lidar operating at 355nm to measure profiles of line-of-sight wind components in near-real-time (NRT). ALADIN samples the atmosphere from 30km altitude down to the Earth's surface or to the level where the lidar signal is attenuated by optically thick clouds. The global wind profiles provided by ALADIN help to improve weather forecasting and the understanding of atmospheric dynamics as they fill observational gaps in vertically resolved wind profiles mainly in the tropics, southern hemisphere, and over the northern hemisphere oceans. In January 2020, the European Centre for Medium-Range Weather Forecasts (ECMWF) became the first numerical weather prediction (NWP) centre to assimilate Aeolus observations for operational forecasting. A main prerequisite for beneficial impact is data of sufficient quality. Such high data quality has been achieved through close collaboration of all involved parties within the Aeolus Data Innovation and Science Cluster (DISC), which was established after launch to study and improve the data quality of Aeolus products. The tasks of the Aeolus DISC include the instrument and platform monitoring, calibration, characterization, retrieval algorithm refinement, processor evolution, quality monitoring, product validation, and impact assessment for NWP. The achievements of the Aeolus DISC for the NRT data quality and the current status of Aeolus wind measurements will be described and summarized. Further, an outlook on future improvements and the availability of reprocessed datasets with enhanced data quality will be provided