Sn-PILC: A novel Efficient and Recyclable Catalyst for One-pot Three Component Povarov’s Inverse-electron-demand Hetero Diels-Alder Reaction for a Facile Synthesis of Tetrahydropyranoquinoline Derivatives under Neat Conditions

The Povarov’s inverse-electron-demand hetero Diels–Alder one-pot three components reaction of aromatic aldehyde, aromatic amine with DHF has been developed using Sn-PILC as a catalyst under a neat condition which may helpful to society to get pharmacologically more active compounds. In the present study a novel series of tetrahydroquinoline 4(a-f) were synthesized and characterized by IR, 1HNMR, 13CNMR, Mass spectral analysis and elemental analysis. The synthetic details and characterization results are discussed. DOI: http://dx.doi.org/10.17807/orbital.v8i3.80

SCREENING OF ANTIMICROBIAL ACTIVITY OF HERABAL EXTRACT OF MORINDA PUBESCENCEâ€, CHLORHEXIDINE & AMOXICILLIN AGAINST SALIVARY MICROFLORA OF MIXED DENTITION AGE GROUP.

Objectives : In  this  study  the  Antimicrobial  activity  of  active Morinda Pubescenceâ€in  acetone  extracts  were  compared with  Chlorhexidine  and  Amoxicillin  125mg  and  Amoxicillin  250mg  against  human  salivary  microflora  at  different  concentrations. Method : The  antimicrobial  activity  was  assisted  by  measuring  the  inhibition  zones  by well  diffusion  method.  Saliva  was  collected  from  children  of  age  group  6-12  years  having DMFT  value  four  or  above  four.  Ten  salivary  samples  were  tested  for  antimicrobial  property  to  determine  the  Minimum  Inhibition  Concentration  in  order  to  increase  the  reliability  and  precision  of  the  study. Result: This study compares antimicrobial activity of Morinda Pubescenceâ€with  0.2percent  chlorhexidine and Amoxicillin 125mg and Amoxicillin 250mg. The zone of inhibition are measured by excluding the diameter of well. These zones of inhibition are directly proportional to the concentration. Conclusion : The  results  confirmed  the  antimicrobial  potential  of  Morinda Pubescenceâ€plant  at  different  concentrations  in  acetone  extracts  are  comparable  with  chlorhexidine  and Amoxicillin  and  can  be  used  as  preventive  and  therapeutic  measure  in  dentistry

SYNTHESIS AND SPECTRAL STUDIES OF SOME CO-ORDINATION COMPOUNDS

ABSTRACT A new series of complexes of Co(II) and Ni(II) with amino acid and 2-amino-iso butyric acid have been synthesized exhibits 1:2 metal-ligand ratio. Characterization of the ligand as well as complexes has been done on the basis of elemental analysis, Infra-red and magnetic susceptibility measurements. The ligand have been found to Co-ordinate through nitrogen and sulphur atoms. The complexes are binary and ternary complexes and are thermally stable. The present paper describe the formation of complexes of Co(II) and Ni(II) with L-cystein and 2-amino is butyric acid

OVERVIEW ON PERFORMANCE- BASED DESIGN OPTIMIZATION OF STEEL STRUCTURES SUBJECTED TO WIND LOAD BY USING E-TAB SOFTWARE

This paper presents a performance- based design optimization of tall steel framed structure exposed to wind loads of various levels by using E Tab software. Its earnings towards design a steel framed structure with an expectable and tolerable performance at four level wind during period of building. To forecast the inelastic drift behaviour of steel building a non-linear static pushover analysis is done

Overview On Performance- Based Design Optimization Of Steel Structures Subjected To Wind Load By Using E-tab Software

This paper presents a performance- based design optimization of tall steel framed structure exposed to wind loads of various levels by using E Tab software. Its earnings towards design a steel framed structure with an expectable and tolerable performance at four level wind during period of building. To forecast the inelastic drift behaviour of steel building a non-linear static pushover analysis is done

Molecular detection of plasmid mediated bla TEM, bla CTX−M,and bla SHV genes in Extended Spectrum β-Lactamase (ESBL) Escherichia coli from clinical samples

Abstract Background Extended spectrum β-lactamases (ESBLs) are a group of beta-lactamase enzymes that confer resistance to the oxyimino-cephalosporins and monobactams. The emergence of ESBL - producing genes possesses a serious threat for treating infections since it is associated with multi-drug resistance. This study was focused to identify the ESBLs producing genes from Escherichia coli isolates from clinical samples from a referral-level tertiary care hospital in Lalitpur. Methods This was a cross-sectional study conducted from September 2018 to April 2020 at the Microbiology Laboratory of Nepal Mediciti Hospital. Clinical samples were processed, and culture isolates were identified and characterized following standard microbiological techniques. An antibiotic susceptibility test was performed by a modified Kirby-Bauer disc diffusion method as recommended by Clinical and Laboratory Standard Institute guidelines.Extended -spectrum beta-lactamases were phenotypically confirmed by the combined disc method. The ESBL-producing genes bla TEM, bla CTX−M and bla SHV were confirmed by PCR. Results Of the 1449 total E. coli isolates, 22.29% (323/1449) isolates were multi-drug resistant (MDR). Among the total MDR E. coli isolates, 66.56% (215/323) were ESBL producers. The maximum number of ESBL E. coli was isolated from urine 90.23% (194) followed by sputum 5.58% (12), swab 2.32% (5), pus 0.93% (2), and blood 0.93% (2). The antibiotic susceptibility pattern of ESBL E. coli producers showed the highest sensitivity toward tigecycline (100%) followed by polymyxin b, colistin and meropenem. Out of 215 phenotypically confirmed ESBL E. coli, only 86.51% (186) isolates were found to be positive by PCR for either bla TEM or bla CTX−M genes. Among the ESBL genotypes, the most common were bla TEM 63.4% (118) followed by bla CTX−M 36.6% (68). Conclusion The emergence of MDR and ESBL – producing E. coli isolates with high antibiotic – resistant rates to commonly used antibiotics and increased predominance of major gene types bla TEM is a serious concern to the clinicians and microbiologists. Periodic monitoring of antibiotic susceptibility and associated genes would help guide the rationale use of antibiotics for treating the predominant pathogen E. coli in the hospitals and healthcare facilities of the communities