1,351 research outputs found
Cross-sectional and longitudinal atrophy is preferentially associated with tau rather than amyloid β positron emission tomography pathology
Understanding pattern scaling errors across a range of emissions pathways
The regional climate impacts of hypothetical future emissions scenarios can be estimated by combining Earth system model simulations with a linear pattern scaling model such as MESMER (Modular Earth System Model Emulator with spatially Resolved output), which uses estimated patterns of the local response per degree of global temperature change. Here we use the mean trend component of MESMER to emulate the regional pattern of the surface temperature response based on historical single-forcer and future Shared Socioeconomic Pathway (SSP) CMIP6 (Coupled Model Intercomparison Project Phase 6) simulations. Errors in the emulations for selected target scenarios (SSP1–1.9, SSP1–2.6, SSP2–4.5, SSP3–7.0, and SSP5–8.5) are decomposed into two components, namely (1) the differences in scaling patterns between scenarios as a consequence of varying combinations of external forcings and (2) the intrinsic time series differences between the local and global responses in the target scenario. The time series error is relatively small for high-emissions scenarios, contributing around 20 % of the total error, but is similar in magnitude to the pattern error for lower-emissions scenarios. This irreducible time series error limits the efficacy of linear pattern scaling for emulating strong mitigation pathways and reduces the dependence on the predictor pattern used. The results help guide the choice of predictor scenarios for simple climate models and where to target for the introduction of other dependent variables beyond global surface temperature into pattern scaling models
Measuring black-hole parameters and testing general relativity using gravitational-wave data from space-based interferometers
Among the expected sources of gravitational waves for the Laser
Interferometer Space Antenna (LISA) is the capture of solar-mass compact stars
by massive black holes residing in galactic centers. We construct a simple
model for such a capture, in which the compact star moves freely on a circular
orbit in the equatorial plane of the massive black hole. We consider the
gravitational waves emitted during the late stages of orbital evolution,
shortly before the orbiting mass reaches the innermost stable circular orbit.
We construct a simple model for the gravitational-wave signal, in which the
phasing of the waves plays the dominant role. The signal's behavior depends on
a number of parameters, including , the mass of the orbiting star, ,
the mass of the central black hole, and , the black hole's angular momentum.
We calculate, using our simplified model, and in the limit of large
signal-to-noise ratio, the accuracy with which these quantities can be
estimated during a gravitational-wave measurement. Our simplified model also
suggests a method for experimentally testing the strong-field predictions of
general relativity.Comment: ReVTeX, 16 pages, 5 postscript figure
Molecular structures and vibrations of neutral and anionic CuOx (x = 1-3,6) clusters
We report equilibrium geometric structures of CuO2, CuO3, CuO6, and CuO
clusters obtained by an all-electron linear combination of atomic orbitals
scheme within the density-functional theory with generalized gradient
approximation to describe the exchange-correlation effects. The vibrational
stability of all clusters is examined on the basis of the vibrational
frequencies. A structure with Cs symmetry is found to be the lowest-energy
structure for CuO2, while a -shaped structure with C2v symmetry is the most
stable structure for CuO3. For the larger CuO6 and CuO clusters, several
competitive structures exist with structures containing ozonide units being
higher in energy than those with O2 units. The infrared and Raman spectra are
calculated for the stable optimal geometries. ~Comment: Uses Revtex4, (Better quality figures can be obtained from authors
Radical functionalization of unsaturated amino acids: synthesis of side-chain-fluorinated, azido-substituted, and hydroxylated amino acids
A range of enantiomerically pure protected side-chain-fluorinated amino acids has been prepared (13 examples) by treatment of protected amino acids containing unsaturated side chains with a combination of Fe(III)/NaBH4 and Selectfluor. The modification of the conditions by replacement of Selectfluor with NaN3 allowed the preparation of side-chain azido-substituted amino acids (five examples), which upon catalytic hydrogenation gave the corresponding amines, isolated as lactams (four examples). Radical hydration of the unsaturated side chains leading to side-chain-hydroxylated protected amino acids has also been demonstrated
Mitochondrial Genetic Differentiation of Spirlin (Actinopterigii: Cyprinidae) in the South Caspian Sea basin of Iran
Background Knowledge about Alburnoides remains lacking relative to many other species, resulting in a lack of a systematic position and taxonomic diagnosis. Basic biological information for Alburnoides has been constructed, and it is necessary to understand further and obtain more information about this species. Its phylogenetic relationships are still debated and no molecular data have been used to study this taxon in Iran. A holistic approach for genetic methods was adopted to analyze possible spirlin population differences at selected centers in the south Caspian Sea basin of Iran. Methods The phylogenetic relationships were determined based on 774 base pairs of the mitochondrial cytochrome b gene of 32 specimens of spirlin from nine locations in the south Caspian Sea drainage basin of Iran. The nucleotide sequences were subjected to phylogenetic analysis using the neighbor-joining, maximum parsimony, maximum likelihood, and Bayesian methods. Results The mitochondrial gene tree largely supports the existence of three major clades. The western populations (clade I) may be considered as Alburnoides eichwaldii , whereas the Talar river populations (clade II) are represented as Alburnoides sp. 1 and the eastern populations (clade III) may be distinct taxa of Alburnoides sp.2. Conclusion This molecular evidence supports the hypothesis that A. bipunctatus does not exist in the south Caspian Sea basin of Iran, and that the western and eastern populations are distinct taxa
The association between blood metals and hypertension in the GuLF study
Background: Both essential and non-essential metals come from natural and anthropogenic sources. Metals can bioaccumulate in humans and may impact human health, including hypertension. Methods: Blood metal (cadmium, lead, mercury, manganese, and selenium) concentrations were measured at baseline for a sample of participants in the Gulf Long-Term Follow-up (GuLF) Study. The GuLF Study is a prospective cohort study focused on potential health effects following the 2010 Deepwater Horizon oil spill. Hypertension was defined as high systolic (≥140 mm Hg) or diastolic (≥90 mm Hg) blood pressure or taking anti-hypertensive medications. A total of 957 participants who had blood measurement for at least one metal, baseline blood pressure measurements, information on any anti-hypertensive medication use, and relevant covariates were included in this cross-sectional analysis. We used Poisson regression to explore the association between individual blood metal levels and hypertension. Quantile-based g-computation was used to investigate the association between the metal mixture and hypertension. We also explored the association between individual blood metal levels and continuous blood pressure measurements using general linear regression. Results: Comparing the highest quartile of blood metals with the lowest (Q4vs1), the hypertension prevalence ratio (PR) was 0.92 (95 % confidence interval (CI) = 0.73,1.15) for cadmium, 0.86 (95%CI = 0.66,1.12) for lead, 0.89 (95%CI = 0.71,1.12) for mercury, 1.00 (95%CI = 0.80,1.26) for selenium, and 1.22 (95%CI = 0.95,1.57) for manganese. We observed some qualitative differences across race and BMI strata although none of these differences were statistically significant. In stratified analyses, the PR (Q4vs1) for mercury was 0.69 (95%CI = 0.53, 0.91) in White participants and 1.29 (95%CI = 0.86,1.92) in Black participants (p for interaction = 0.5). The PR (Q4vs1) for manganese was relatively higher in Black participants (PR = 1.37, 95%CI = 0.92,2.05) than in White participants (PR = 1.15, 95%CI = 0.83,1.60, p for interaction = 0.5), with a suggestive dose-response among Blacks. After stratifying by obesity (BMI ≥30 and < 30), positive associations of of hypertension with cadmium (PR [Q4vs1] = 1.19, 95%CI = 0.91,1.56, p for interaction = 0.5), lead (PR [Q4vs1] = 1.14, 95%CI = 0.84,1.55, p for interaction = 1.0) and manganese (PR = 1.25, 95%CI = 0.93,1.68, p for interaction = 0.8) were observed in participants with BMI≥30, but not in participants with BMI<30. The joint effect of the metal mixture was 0.96 (95%CI = 0.73,1.27). We did not observe clear associations between blood metal levels and continuous blood pressure measurements. Conclusion: We did not find overall cross-sectional associations between blood cadmium, lead, mercury, selenium levels and hypertension or blood pressure. We found some evidence suggesting that manganese might be positively associated with risk of hypertension. Associations varied somewhat by race and BMI
Microwave-induced control of Free Electron Laser radiation
The dynamical response of a relativistic bunch of electrons injected in a
planar magnetic undulator and interacting with a counterpropagating
electromagnetic wave is studied. We demonstrate a resonance condition for which
the free electron laser (FEL) dynamics is strongly influenced by the presence
of the external field. It opens up the possibility of control of short
wavelength FEL emission characteristics by changing the parameters of the
microwave field without requiring change in the undulator's geometry or
configuration. Numerical examples, assuming realistic parameter values
analogous to those of the TTF-FEL, currently under development at DESY, are
given for possible control of the amplitude or the polarization of the emitted
radiation.Comment: 14 pages, 5 figures, accepted for publication in Phys. Rev.
Environmental studies data base development and data synthesis activities of the US Subseabed Disposal Program
The US Subseabed Disposal Program is assessing the scientific feasibility of subseabed emplacement of high-level nuclear wastes. Studies of disposal methods and of the barriers to radionuclide migration (canister, waste form and sediment) suggest that environmental information will be needed to address the impact of accidental release of radionuclides in the deep sea. Biological, physical, and geochemical data are being collected from field and laboratory studies as well as from literature searches. These data are being analyzed using a multicompartmental radionuclide transport model and appropriate physical oceanographic models. The data integrated into this framework will help answer two questions: what are the environmental effects of radionuclides which may be released in the deep sea, and what are the effects of such a release upon man
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