Safe Injection Facilities: Reconsidering American Drug Policy

On January 12, 2021, in United States v. Safehouse, the U.S. Court of Appeals for the Third Circuit held that supervised injection facilities—sites where medical professionals monitor injection drug use—violate the Crack House Statute. The legality of supervised injection facilities was a matter of first impression at the circuit level. Research shows that supervised injection facilities reduce overdose deaths and the spread of infection and are important harm reduction measures for combatting the opioid epidemic. The Third Circuit held that these programs violate the Crack House Statute, 21 U.S.C. § 856(a)(2), because they act with the statutorily proscribed purpose of drug use. Within its opinion, the Third Circuit noted that the word “purpose” in the provision pertains to the drug users. The Third Circuit’s determination that the statute does not require the property managers to hold an illicit purpose conflicted with the U.S. District Court for the Eastern District of Pennsylvania’s opinion, which found supervised injection facilities to be legal. This Note maintains that the Third Circuit erred in concluding that “purpose” refers to the drug users and argues that it instead modifies the site operator. This Note further argues that American drug law is inapposite to treating and ending the opioid epidemic. Thus, this Note concludes by calling on Congress to incorporate addiction research findings into future drug policy

Identification of a mutation in the para-sodium channel gene of the cattle tick Rhipicephalus (Boophilus) microplus associated with resistance to synthetic pyrethroid acaricides

Resistance against synthetic pyrethroid (SP) products for the control of cattle ticks in Australia was detected in the field in 1984, within a very short time of commercial introduction. We have identified a mutation in the domain II S4-5 linker of the para-sodium channel that is associated with resistance to SPs in the cattle tick Rhipicephalus (Boophilus) microplus from Australia. The cytosine to adenine mutation at position 190 in the R. microplus sequence AF134216, results in an amino acid substitution from leucine in the susceptible strain to isoleucine in the resistant strain. A similar mutation has been shown to confer SP resistance in the whitefly, Bemisia tabaci, but has not been described previously in ticks. A diagnostic quantitative PCR assay has been developed using allele-specific Taqman® minor groove-binding (MGB) probes. Using the assay to screen field and laboratory populations of ticks showed that homozygote allelic frequencies correlated highly with the survival percentage at the discriminating concentration of cypermethrin

The nonlinear damping of Bose-Einstein condensate oscillations at ultra-low temperatures

We analyze the damping of the transverse breathing mode in an elongated trap at ultralow temperatures. The damping occurs due to the parametric resonance entailing the energy transfer to the longitudinal degrees of freedom. It is found that the nonlinear coupling between the transverse and discrete longitudinal modes can result in an anomalous behavior of the damping as a function of time with the partially reversed pumping of the breathing mode. The picture revealed explains the results observed in [16]

Coin Tossing as a Billiard Problem

We demonstrate that the free motion of any two-dimensional rigid body colliding elastically with two parallel, flat walls is equivalent to a billiard system. Using this equivalence, we analyze the integrable and chaotic properties of this new class of billiards. This provides a demonstration that coin tossing, the prototypical example of an independent random process, is a completely chaotic (Bernoulli) problem. The related question of which billiard geometries can be represented as rigid body systems is examined.Comment: 16 pages, LaTe

Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection

Unassisted metastasis through the lymphatic system is a mechanism of dissemination thus far ascribed only to cancer cells. Here, we report that Streptococcus pyogenes also hijack lymphatic vessels to escape a local infection site, transiting through sequential lymph nodes and efferent lymphatic vessels to enter the bloodstream. Contrasting with previously reported mechanisms of intracellular pathogen carriage by phagocytes, we show S. pyogenes remain extracellular during transit, first in afferent and then efferent lymphatics that carry the bacteria through successive draining lymph nodes. We identify streptococcal virulence mechanisms important for bacterial lymphatic dissemination and show that metastatic streptococci within infected lymph nodes resist and subvert clearance by phagocytes, enabling replication that can seed intense bloodstream infection. The findings establish the lymphatic system as both a survival niche and conduit to the bloodstream for S. pyogenes, explaining the phenomenon of occult bacteraemia. This work provides new perspectives in streptococcal pathogenesis with implications for immunity

Facultative Aestivation in a Tropical Freshwater Turtle Chelodina rugosa

Abstract-1. Chelodina rugosa dug from aestivation sites at the end of the dry season were immediately alert and well coordinated. 2. Compared with non-aestivating animals, aestivating turtles had 20% higher plasma osmotic pressure and 7% higher sodium. Coupled with a small, but significant weight gain upon return to the water, this suggested the occurrence of minor dehydration in aestivating animals. 3. Plasma lactate levels of aestivating animals were low, averaging 1.99 mmol/1, consistent with aerobic rather than anaerobic metabolism having sustained their long period under ground. 4. No evidence was seen of dramatic physiological specialization. Aestivation in this species is interpreted as a primarily behavioural adaptation, made possible by typically reptilian abilities to tolerate a wide range in plasma electrolytes and to survive long periods without feeding

Surface and capillary transitions in an associating binary mixture model

We investigate the phase diagram of a two-component associating fluid mixture in the presence of selectively adsorbing substrates. The mixture is characterized by a bulk phase diagram which displays peculiar features such as closed loops of immiscibility. The presence of the substrates may interfere the physical mechanism involved in the appearance of these phase diagrams, leading to an enhanced tendency to phase separate below the lower critical solution point. Three different cases are considered: a planar solid surface in contact with a bulk fluid, while the other two represent two models of porous systems, namely a slit and an array on infinitely long parallel cylinders. We confirm that surface transitions, as well as capillary transitions for a large area/volume ratio, are stabilized in the one-phase region. Applicability of our results to experiments reported in the literature is discussed.Comment: 12 two-column pages, 12 figures, accepted for publication in Physical Review E; corrected versio

Measuring black-hole parameters and testing general relativity using gravitational-wave data from space-based interferometers

Among the expected sources of gravitational waves for the Laser Interferometer Space Antenna (LISA) is the capture of solar-mass compact stars by massive black holes residing in galactic centers. We construct a simple model for such a capture, in which the compact star moves freely on a circular orbit in the equatorial plane of the massive black hole. We consider the gravitational waves emitted during the late stages of orbital evolution, shortly before the orbiting mass reaches the innermost stable circular orbit. We construct a simple model for the gravitational-wave signal, in which the phasing of the waves plays the dominant role. The signal's behavior depends on a number of parameters, including $\mu$, the mass of the orbiting star, $M$, the mass of the central black hole, and $J$, the black hole's angular momentum. We calculate, using our simplified model, and in the limit of large signal-to-noise ratio, the accuracy with which these quantities can be estimated during a gravitational-wave measurement. Our simplified model also suggests a method for experimentally testing the strong-field predictions of general relativity.Comment: ReVTeX, 16 pages, 5 postscript figure