Supermembrane interaction with dynamical D=4 N=1 supergravity. Superfield Lagrangian description and spacetime equations of motion

We obtain the complete set of equations of motion for the interacting system of supermembrane and dynamical D=4 N = 1 supergravity by varying its complete superfield action and writing the resulting superfield equations in the special gauge where the supermembrane Goldstone field is set to zero. We solve the equations for auxiliary fields and discuss the effect of dynamical generation of cosmological constant in the Einstein equation of interacting system and its renormalization due to some regular contributions from supermembrane. These two effects (discussed in late 70th and 80th, in the bosonic perspective and in the supergravity literature) result in that, generically, the cosmological constant has different values in the branches of the spacetime separated by the supermembrane worldvolume.Comment: 23 pages, no figures. V2 two references added, 24 page

Renormalization in General Gauge Mediation

We revisit General Gauge Mediation (GGM) in light of the supersymmetric (linear) sigma model by utilizing the current superfield. The current superfield in the GGM is identified with supersymmetric extension of the vector symmetry current of the sigma model while spontaneous breakdown of supersymmetry in the GGM corresponds to soft breakdown of the axial vector symmetry of the sigma model. We first derive the current superfield from the supersymmetric linear sigma model and then compute 2-point functions of the current superfield using the (anti-)commutation relations of the messenger component fields. After the global symmetry are weakly gauged, the 2-point functions of the current superfield are identified with a part of the 2-point functions of the associated vector superfield. We renormalize them by dimensional regularization and show that physical gaugino and sfermion masses of the MSSM are expressed in terms of the wavefunction renormalization constants of the component fields of the vector superfield.Comment: 25 pages, 12 figure

Probing CP Violation with and without Momentum Reconstruction at the LHC

We study the potential to observe CP-violating effects in SUSY cascade decay chains at the LHC. We consider squark and gluino production followed by subsequent decays into neutralinos with a three-body leptonic decay in the final step. Asymmetries composed by triple products of momenta of the final state particles are sensitive to CP-violating effects. Due to large boosts these asymmetries can be difficult to observe at a hadron collider. We show that using all available kinematic information one can reconstruct the decay chains on an event-by-event basis even in the case of 3-body decays, neutrinos and LSPs in the final state. We also discuss the most important experimental effects like major backgrounds and momentum smearing due to finite detector resolution. We show that with 300 fb$^{-1}$ of collected data, CP violation may be discovered at the LHC for a wide range of the phase of the bino mass parameter $M_1$.Comment: Version accepted for publication in JHEP. Clarifications added on the assumptions used for plots. New references adde

Constraints on the pMSSM from searches for squarks and gluinos by ATLAS

We study the impact of the jets and missing transverse momentum SUSY analyses of the ATLAS experiment on the phenomenological MSSM (pMSSM). We investigate sets of SUSY models with a flat and logarithmic prior in the SUSY mass scale and a mass range up to 1 and 3 TeV, respectively. These models were found previously in the study 'Supersymmetry without Prejudice'. Removing models with long-lived SUSY particles, we show that 99% of 20000 randomly generated pMSSM model points with a flat prior and 87% for a logarithmic prior are excluded by the ATLAS results. For models with squarks and gluinos below 600 GeV all models of the pMSSM grid are excluded. We identify SUSY spectra where the current ATLAS search strategy is less sensitive and propose extensions to the inclusive jets search channel

Electroweak Symmetry Breaking in the DSSM

We study the theoretical and phenomenological consequences of modifying the Kahler potential of the MSSM two Higgs doublet sector. Such modifications naturally arise when the Higgs sector mixes with a quasi-hidden conformal sector, as in some F-theory GUT models. In the Delta-deformed Supersymmetric Standard Model (DSSM), the Higgs fields are operators with non-trivial scaling dimension 1 < Delta < 2. The Kahler metric is singular at the origin of field space due to the presence of quasi-hidden sector states which get their mass from the Higgs vevs. The presence of these extra states leads to the fact that even as Delta approaches 1, the DSSM does not reduce to the MSSM. In particular, the Higgs can naturally be heavier than the W- and Z-bosons. Perturbative gauge coupling unification, a large top quark Yukawa, and consistency with precision electroweak can all be maintained for Delta close to unity. Moreover, such values of Delta can naturally be obtained in string-motivated constructions. The quasi-hidden sector generically contains states charged under SU(5)_GUT as well as gauge singlets, leading to a rich, albeit model-dependent, collider phenomenology.Comment: v3: 40 pages, 3 figures, references added, typos correcte

Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor

derived cells (CDCs) are a cardiac progenitor cell population, which have been shown to possess cardiac regenerative properties and can improve heart function in a variety of cardiac diseases. Studies in large animal models have predominantly focussed on using autologous cells for safety, however allogeneic cell banks would allow for a practical, cost-effective and efficient use in a clinical setting. The aim of this work was to determine the immunomodulatory status of these cells using CDCs and lymphocytes from 5 dogs. CDCs expressed MHC I but not MHC II molecules and in mixed lymphocyte reactions demonstrated a lack of lymphocyte proliferation in response to MHC-mismatched CDCs. Furthermore, MHC-mismatched CDCs suppressed lymphocyte proliferation and activation in response to Concanavalin A. Transwell experiments demonstrated that this was predominantly due to direct cell-cell contact in addition to soluble mediators whereby CDCs produced high levels of PGE2 under inflammatory conditions. This led to down-regulation of CD25 expression on lymphocytes via the EP4 receptor. Blocking prostaglandin synthesis restored both, proliferation and activation (measured via CD25 expression) of stimulated lymphocytes. We demonstrated for the first time in a large animal model that CDCs inhibit proliferation in allo-reactive lymphocytes and have potent immunosuppressive activity mediated via PGE2

Hadronic production of squark-squark pairs: The electroweak contributions

We compute the electroweak (EW) contributions to squark--squark pair production processes at the LHC within the framework of the Minimal Supersymmetric Standard Model (MSSM). Both tree-level EW contributions, of O(alpha_s alpha + alpha^2), and next-to-leading order (NLO) EW corrections, of O(alpha_s^2 alpha), are calculated. Depending on the flavor and chirality of the produced quarks, many interferences between EW-mediated and QCD-mediated diagrams give non-zero contributions at tree-level and NLO. We discuss the computational techniques and present an extensive numerical analysis for inclusive squark--squark production as well as for subsets and single processes. While the tree-level EW contributions to the integrated cross sections can reach the 20% level, the NLO EW corrections typically lower the LO prediction by a few percent.Comment: 36 pages, 18 figure

Supersymmetric top and bottom squark production at hadron colliders

The scalar partners of top and bottom quarks are expected to be the lightest squarks in supersymmetric theories, with potentially large cross sections at hadron colliders. We present predictions for the production of top and bottom squarks at the Tevatron and the LHC, including next-to-leading order corrections in supersymmetric QCD and the resummation of soft gluon emission at next-to-leading-logarithmic accuracy. We discuss the impact of the higher-order corrections on total cross sections and transverse-momentum distributions, and provide an estimate of the theoretical uncertainty due to scale variation and the parton distribution functions.Comment: 29 pages, 6 figure

Dangerous Skyrmions in Little Higgs Models

Skyrmions are present in many models of electroweak symmetry breaking where the Higgs is a pseudo-Goldstone boson of some strongly interacting sector. They are stable, composite objects whose mass lies in the range 10-100 TeV and can be naturally abundant in the universe due to their small annihilation cross-section. They represent therefore good dark matter candidates. We show however in this work that the lightest skyrmion states are electrically charged in most of the popular little Higgs models, and hence should have been directly or indirectly observed in nature already. The charge of the skyrmion under the electroweak gauge group is computed in a model-independent way and is related to the presence of anomalies in the underlying theory via the Wess-Zumino-Witten term.Comment: 31 pages, 4 figures; v2: minor changes, one reference added, version to appear in JHEP; v3: erratum added, conclusions unchange

M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss

This is the final version of the article. Available from American Society for Clinical Investigation via the DOI in this record.The current frontline symptomatic treatment for Alzheimer’s disease (AD) is whole-body upregulation of cholinergic transmission via inhibition of acetylcholinesterase. This approach leads to profound dose-related adverse effects. An alternative strategy is to selectively target muscarinic acetylcholine receptors, particularly the M1 muscarinic acetylcholine receptor (M1 mAChR), which was previously shown to have procognitive activity. However, developing M1 mAChR–selective orthosteric ligands has proven challenging. Here, we have shown that mouse prion disease shows many of the hallmarks of human AD, including progressive terminal neurodegeneration and memory deficits due to a disruption of hippocampal cholinergic innervation. The fact that we also show that muscarinic signaling is maintained in both AD and mouse prion disease points to the latter as an excellent model for testing the efficacy of muscarinic pharmacological entities. The memory deficits we observed in mouse prion disease were completely restored by treatment with benzyl quinolone carboxylic acid (BQCA) and benzoquinazoline-12 (BQZ-12), two highly selective positive allosteric modulators (PAMs) of M1 mAChRs. Furthermore, prolonged exposure to BQCA markedly extended the lifespan of diseased mice. Thus, enhancing hippocampal muscarinic signaling using M1 mAChR PAMs restored memory loss and slowed the progression of mouse prion disease, indicating that this ligand type may have clinical benefit in diseases showing defective cholinergic transmission, such as AD.ABT, AC, and PMS received funding from a Wellcome Trust Collaborative Award (201529/Z/16/Z). ABT, SJB, AJB, and TMH were funded through a Medical Research Council programme leader grant provided by the MRC Toxicology Unit. CCF, LMB, AJM, and HES were funded by the Eli Lilly Company. JMB received funding through a Lilly Research Award Program (LRAP) grant (Eli Lilly). RP received funding from the Marie Curie grant “Extrabrain” (European Commission). AC is a senior principal research fellow and PMS a principal research fellow of the National Health and Medical Research Council of Australia. Tissue samples were from Randy Woltjer at the Oregon Alzheimer’s Disease Center. The Oregon Alzheimer’s Disease Center is supported by NIH grant P30AG008017