Lightning rods, earthquakes, and regional identities: towards a multi-scale framework of assessing fracking risk perception

Hydraulic fracturing has provided a persistent, polarizing, and highly politicized source of controversy internationally, and in numerous national contexts for just under a decade. This research uses fracking operations in New Zealand as a vignette through which to understand the underlying causes of controversy and the appropriateness of attempts to address them. A multi-method approach using interviews (n=25), diagrammatic analysis, and newsprint media was applied to evidence two major findings. Firstly, previous attempts to explain fracking controversy based on social constructivist theory lack a multi-scalar approach to the assessment of factors that influence risk perceptions. It is found that risk perception surrounding fracking in New Zealand reflects intra-scalar interactions between factors originating at the international, national, regional and local scale. Secondly, there is a concerning absence of critique pertaining to the concept of ‘social license to operate’ (SLO), which has been advocated both internationally and nationally as an appropriate form of stakeholder engagement. This paper contributes to the SLO outcomes literature by establishing a need to consider multi-scalar influences on risk perception when explaining diverse SLO outcomes in communities where fracking operations are prospective or already taking place.David Richards Travel Scholarship; Jesus College Travel Grant; Bedford Travel Grant; Mary Euphrasia Mosley, Sir Bartle Frere & Worts Travel Funds. NERC/ESRC Data, Risk and Environmental Analytical Methods (DREAM) Centre, Grant/Award Number: NE/M009009/

The interactive relationship between coastal erosion and flood risk

Coastal erosion and flooding are hazards that, when combined with facilitative pathways and vulnerable receptors, represent sources of coastal risk. Erosion and flooding risks are often analysed separately owing to complex relationships between driving processes, morphological response and risk receptors. We argue that these risks should be considered jointly and illustrate this through discussion of three ‘expressions’ of this interactive relationship: coastal morphology modifies flood hazard; future flood risk depends on changing shoreline position; and the simultaneous occurrence of erosion–flooding events. Some critical thoughts are offered on the general applicability of these expressions and the implications for coastal risk management policy. This research is funded by the NERC/ESRC Data, Risk and Environmental Analytical Methods (DREAM) Centre, Grant/Award Number: NE/M009009/

Exploring differential item functioning in the SF-36 by demographic, clinical, psychological and social factors in an osteoarthritis population

The SF-36 is a very commonly used generic measure of health outcome in osteoarthritis (OA). An important, but frequently overlooked, aspect of validating health outcome measures is to establish if items work in the same way across subgroup of a population. That is, if respondents have the same 'true' level of outcome, does the item give the same score in different subgroups or is it biased towards one subgroup or another. Differential item functioning (DIF) can identify items that may be biased for one group or another and has been applied to measuring patient reported outcomes. Items may show DIF for different conditions and between cultures, however the SF-36 has not been specifically examined in an osteoarthritis population nor in a UK population. Hence, the aim of the study was to apply the DIF method to the SF-36 for a UK OA population. The sample comprised a community sample of 763 people with OA who participated in the Somerset and Avon Survey of Health. The SF-36 was explored for DIF with respect to demographic, social, clinical and psychological factors. Well developed ordinal regression models were used to identify DIF items. Results: DIF items were found by age (6 items), employment status (6 items), social class (2 items), mood (2 items), hip v knee (2 items), social deprivation (1 item) and body mass index (1 item). Although the impact of the DIF items rarely had a significant effect on the conclusions of group comparisons, in most cases there was a significant change in effect size. Overall, the SF-36 performed well with only a small number of DIF items identified, a reassuring finding in view of the frequent use of the SF-36 in OA. Nevertheless, where DIF items were identified it would be advisable to analyse data taking account of DIF items, especially when age effects are the focus of interest

Impact of management regime and regime change on gravel barrier response to a major storm surge

Gravel barriers represent physiographic, hydrographic, sedimentary, and ecological boundaries between inshore and open marine offshore environments, where they provide numerous important functions. The morphosedimentary features of gravel barriers (e.g., steep, energy reflective form) have led to their characterization as effective coastal defense features during extreme hydrodynamic conditions. Consequently, gravel barriers have often been intensively managed to enhance coastal defense functions. The Blakeney Point Barrier System (BPBS), U.K., is one such example, which offers the opportunity to investigate the impact of alternative management regimes under extreme hydrodynamic conditions. The BPBS was actively re-profiled along its eastern section from the 1950s to the winter of 2005, whilst undergoing no active intervention along its western section. Combining an analysis of remotely sensed elevation datasets with numerical storm surge modeling, this paper finds that interventionist management introduces systemic differences in barrier morphological characteristics. Overly steepened barrier sections experience greater wave run-up extents during storm surge conditions, leading to more extreme morphological changes and landward barrier retreat. Furthermore, while high, steep barriers can be highly effective at preventing landward flooding, in cases where overwashing does occur, the resultant landward overtopping volume is typically higher than would be the case for a relatively lower crested barrier with a lower angled seaward slope. There is a growing preference within coastal risk management for less interventionist management regimes, incorporating natural processes. However, restoring natural processes does not immediately or inevitably result in a reduction in coastal risk. This paper contributes practical insights regarding the time taken for a previously managed barrier to relax to a more natural state, intermediary morphological states, and associated landward water flows during extreme events, all of which should be considered if gravel barriers are to be usefully integrated into broader risk management strategies.</jats:p

Myosin-I nomenclature.

We suggest that the vertebrate myosin-I field adopt a common nomenclature system based on the names adopted by the Human Genome Organization (HUGO). At present, the myosin-I nomenclature is very confusing; not only are several systems in use, but several different genes have been given the same name. Despite their faults, we believe that the names adopted by the HUGO nomenclature group for genome annotation are the best compromise, and we recommend universal adoption

Cortical Factor Feedback Model for Cellular Locomotion and Cytofission

Eukaryotic cells can move spontaneously without being guided by external cues. For such spontaneous movements, a variety of different modes have been observed, including the amoeboid-like locomotion with protrusion of multiple pseudopods, the keratocyte-like locomotion with a widely spread lamellipodium, cell division with two daughter cells crawling in opposite directions, and fragmentations of a cell to multiple pieces. Mutagenesis studies have revealed that cells exhibit these modes depending on which genes are deficient, suggesting that seemingly different modes are the manifestation of a common mechanism to regulate cell motion. In this paper, we propose a hypothesis that the positive feedback mechanism working through the inhomogeneous distribution of regulatory proteins underlies this variety of cell locomotion and cytofission. In this hypothesis, a set of regulatory proteins, which we call cortical factors, suppress actin polymerization. These suppressing factors are diluted at the extending front and accumulated at the retracting rear of cell, which establishes a cellular polarity and enhances the cell motility, leading to the further accumulation of cortical factors at the rear. Stochastic simulation of cell movement shows that the positive feedback mechanism of cortical factors stabilizes or destabilizes modes of movement and determines the cell migration pattern. The model predicts that the pattern is selected by changing the rate of formation of the actin-filament network or the threshold to initiate the network formation

Understanding spatio-temporal barrier dynamics through the use of multiple shoreline proxies

At the coast, risk arises where, and when, static human developments are situated within dynamic surroundings. Barrier islands are often sites of heightened coastal risk since they frequently support substantial human populations and undergo extensive morphological change owing to their low-lying form and persistence in energetic hydrodynamic and meteorological conditions. Using the mixed sand-gravel barrier of Blakeney Point, this study argues that to avoid an only partial understanding of coastal zone processes, it is necessary to make use of multiple shoreline proxies, capturing processes operating both at different timescales and different cross-shore positions. Here, five shoreline proxies were extracted from three data sources. Shoreline error was quantified and compared to observed shoreline change rates to establish proxy-specific, appropriate timescales for shoreline change analysis. The map derived Mean High Water Line at Blakeney Point revealed landward retreat of −0.61 m a−1 over the past 130 years with a shift from drift- towards swash-alignment of the barrier since 1981. Over the past 24 years, the High Water Line, Ridge Line and Vegetation Line reveal proxy-specific response to management regime change. The termination of barrier reprofiling of the eastern section of the barrier has resulted in increased sediment release to the downdrift barrier terminus, buffering retreat there at the expense of the updrift section. The Vegetation Line represents an effective proxy for storm-driven overwash with maximum shoreline retreat during surge events of 172 m, illustrating a strong event-driven component to barrier morphodynamics. By comparison to the other proxies, the LiDAR (Light Detection and Ranging) derived Mean High Water Line offers relatively limited insights into barrier dynamics, emphasising the importance of multi-proxy approaches. In the face of technological advance, we demonstrate the continued importance of critical attention towards the dependencies that exist between shoreline proxy selection and the processes that can be observed as a result.This work was funded by the NERC/ESRC Data, Risk and Environmental Analytical Methods (DREAM) CDT, Grant/Award Number: NE/M009009/1. It is also a contribution to the NERC-funded project “Physical and Biological dynamic coastal processes and their role in coastal recovery” (BLUE-coast), Grant Award Number: NE/N015924/1

Evolution of lysine acetylation in the RNA polymerase II C-terminal domain

© 2015 Simonti et al.; licensee BioMed Central.Background: RPB1, the largest subunit of RNA polymerase II, contains a highly modifiable C-terminal domain (CTD) that consists of variations of a consensus heptad repeat sequence (Y1S2

Quadratic optimal functional quantization of stochastic processes and numerical applications

In this paper, we present an overview of the recent developments of functional quantization of stochastic processes, with an emphasis on the quadratic case. Functional quantization is a way to approximate a process, viewed as a Hilbert-valued random variable, using a nearest neighbour projection on a finite codebook. A special emphasis is made on the computational aspects and the numerical applications, in particular the pricing of some path-dependent European options.Comment: 41 page