A Deficiency Problem of the Least Squares Finite Element Method for Solving Radiative Transfer in Strongly Inhomogeneous Media

The accuracy and stability of the least squares finite element method (LSFEM) and the Galerkin finite element method (GFEM) for solving radiative transfer in homogeneous and inhomogeneous media are studied theoretically via a frequency domain technique. The theoretical result confirms the traditional understanding of the superior stability of the LSFEM as compared to the GFEM. However, it is demonstrated numerically and proved theoretically that the LSFEM will suffer a deficiency problem for solving radiative transfer in media with strong inhomogeneity. This deficiency problem of the LSFEM will cause a severe accuracy degradation, which compromises too much of the performance of the LSFEM and makes it not a good choice to solve radiative transfer in strongly inhomogeneous media. It is also theoretically proved that the LSFEM is equivalent to a second order form of radiative transfer equation discretized by the central difference scheme

VOC Control in Kraft Mills

The formation of volatile organic compounds (VOCs), such as methanol, in kraft mills has been an environmental concern. Methanol is soluble in water and can increase the biochemical oxygen demand. Furthermore, it can also be released into atmosphere at the process temperatures of kraft mill-streams. The Cluster Rule of the EPA now requires the control of the release of methanol in pulp and paper mills. This research program was conducted to develop a computer simulation tool for mills to predict VOC air emissions. To achieve the objective of the research program, much effort was made in the development of analytical techniques for the analysis of VOC and determination of vapor liquid partitioning coefficient of VOCs in kraft mill-streams using headspace gas chromatography. With the developed analytical tool, methanol formation in alkaline pulping was studied in laboratory to provide benchmark data of the amount of methanol formation in pulping in kraft mills and for the validation of VOC formation and vapor-liquid equilibrium submodels. Several millwide air and liquid samplings were conducted using the analytical tools developed to validate the simulation tool. The VOC predictive simulation model was developed based on the basic chemical engineering concepts, i.e., reaction kinetics, vapor liquid equilibrium, combined with computerized mass and energy balances. Four kraft mill case studies (a continuous digester, two brownstock washing lines, and a pre-evaporator system) are presented and compared with mill measurements. These case studies provide valuable, technical information for issues related to MACT I and MACT II compliance, such as condensate collection and Clean-Condensate-Alternatives (CCA)

The trans-ancestral genomic architecture of glycemic traits

Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 x 10(-8)), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.Diabetes mellitus: pathophysiological changes and therap

Regulating Dialogue With Gestures---Towards an Empirically Grounded Simulation with Conversational Agents

Bergmann K, Rieser H, Kopp S. Regulating Dialogue With Gestures---Towards an Empirically Grounded Simulation with Conversational Agents. In: Chai JY, Moore JD, Passonneau RJ, Traum DR, eds. Proceedings of the SIGdial 2011 Conference. Association for Computational Linguistics; 2011: 88-97.Although not very well investigated, a crucial aspect of gesture use in dialogues is to regulate the organisation of the interaction. People use gestures decisively, for example to indicate that they want someone to take the turn, to 'brush away' what someone else said, or to acknowledge others' contributions. We present first insights from a corpus-based investigation of how gestures are used to regulate dialogue, and we provide first results from an account to capture these phenomena in agent-based communication simulations. By advancing a model for autonomous gesture generation to also cover gesture interpretation, this account enables a full gesture turn exchange cycle of generation, understanding and acceptance/generation in virtual conversational agents

Kmup-1 Protects Kidney from Streptozotocin-Induced Pro-Inflammation in Early Diabetic Nephropathy by Restoring Enos/Pparγ and Inhibiting MMP-9

KMUP-1 increases nitric oxide (NO) via endothelium nitric-oxide synthase (eNOS). Deficiency of eNOS and peroxisome proliferator-activated receptor-γ (PPARγ) is the pathogenesis of diabetic nephropathy (DN). This study aims to investigate whether KMUP-1 inhibits streptozotocin (STZ)-induced proinflammation in early DN. In experiments, STZ was used to induce diabetes in Wistar rats. Twenty-four male rats were randomly divided into four groups, including control, STZ (65 mg/kg, i.p.), STZ+KMUP-1(1 mg/kg) and STZ+KMUP-1 (2.5 mg/kg). KMUP-1 HCl was dissolved in distilled water for oral administration. The morphology of renal tissues was evaluated by periodic acid-schiff (PAS) staining and immunohistochemistry of eNOS. The expressions of matrix metalloproteinase-2/-9 (MMP-2/-9), eNOS, B-cell lymphoma 2 (Bcl-2), Bcl-2– associated X protein (Bax) and PPARγ of renal tissues were examined by Western blotting technique. NO production was evaluated by Griess reagent. Oxidative stress was evaluated by measuring reactive oxygen species (ROS). Results indicated that STZ-induced diabetic mellitus (DM) and subsequent DN, including excessive deposition of extracellular matrix (ECM) accompanied by enhanced MMP-2/-9, raised ROS production, increased Bcl-2/Bax ratio and decreased eNOS/PPARy over a period of 4 weeks. KMUP-1 inhibited STZ-induced hyperglycemia, BUN, MMP-2/MMP-9, and restored eNOS-PPARγ expression in renal tissues. Immunohistochemistry (IHC) of eNOS in glomeruli of renal cortical tissue sections indicated that KMUP-1 restored the eNOS caused by STZ. PAS staining of glomeruli indicated that KMUP-1 could not significantly reduce STZ-induced ECM expansion. Moreover, KMUP-1 increased Bcl-2/Bax and decreased ROS. In summary, KMUP-1 inhibits STZ-induced proinflammation in early DN by restoring PPARγ/eNOS and inhibiting MMP-9

Design study of a single bunch selection method for neutron TOF experiment at RAON heavy ion accelerator

To enable neutron time-of-flight (TOF) experiments at the RAON heavy-ion accelerator facility, we propose a single bunch beam selection method by combining a fast chopper and double gap buncher in the low-energy beam transport (LEBT) section. The fast chopper operates with switching times of tens of ns to convert a CW beam into a pulsed beam. Then, the double gap buncher performs bunching to shorten the beam pulse duration to less than one radio frequency quadrupole (RFQ) cycle. Ideally, a single isolated bunch can be achieved after the RFQ. In this study, we discuss the system design of the proposed single bunch selection scheme and present detailed beam dynamics simulations