1,155 research outputs found
VELOCITY AND ACCURACY AS PERFORMANCE CRITERIA FOR THREE DIFFERENT SOCCER KICKING TECHNIQUES
Kicking velocity (KV) and kicking accuracy (KA) of 19 experienced male soccer players were examined for the full instep, the inner instep, and the side foot kick. Measurements were performed simultaneously by a radar gun (KV) and a newly introduced high-speed-video camera set-up (KA). Subjects had two different tasks: to kick as fast as possible (Max KV) and to kick as accurate as possible (Max KA) with each kicking technique. Six repetitive kicks were performed for each required condition. The full instep and the inner instep kick were faster compared to the side foot kick for both performance tasks. In contrast, the side foot kick was the more accurate technique compared to the inner instep and the full instep kick, also for both performance tasks. Kicking variability between and within subjects was generally low for KV and generally high for KA for all kicking. It is concluded that velocity control is easier to achieve than accuracy control for soccer kicks
Drug distribution in brain and cerebrospinal fluids in relation to IC50 values in aging and Alzheimer's disease, using the physiologically based LeiCNS-PK3.0 model
Background Very little knowledge exists on the impact of Alzheimer's disease on the CNS target site pharmacokinetics (PK). Aim To predict the CNS PK of cognitively healthy young and elderly and of Alzheimer's patients using the physiologically based LeiCNS-PK3.0 model. Methods LeiCNS-PK3.0 was used to predict the PK profiles in brain extracellular (brain(ECF)) and intracellular (brain(ICF)) fluids and cerebrospinal fluid of the subarachnoid space (CSFSAS) of donepezil, galantamine, memantine, rivastigmine, and semagacestat in young, elderly, and Alzheimer's patients. The physiological parameters of LeiCNS-PK3.0 were adapted for aging and Alzheimer's based on an extensive literature search. The CNS PK profiles at plateau for clinical dose regimens were related to in vitro IC50 values of acetylcholinesterase, butyrylcholinesterase, N-methyl-D-aspartate, or gamma-secretase. Results The PK profiles of all drugs differed between the CNS compartments regarding plateau levels and fluctuation. Brain(ECF), brain(ICF) and CSFSAS PK profile relationships were different between the drugs. Aging and Alzheimer's had little to no impact on CNS PK. Rivastigmine acetylcholinesterase IC50 values were not reached. Semagacestat brain PK plateau levels were below the IC50 of gamma-secretase for half of the interdose interval, unlike CSFSAS PK profiles that were consistently above IC50. Conclusion This study provides insights into the relations between CNS compartments PK profiles, including target sites. CSFSAS PK appears to be an unreliable predictor of brain PK. Also, despite extensive changes in blood-brain barrier and brain properties in Alzheimer's, this study shows that the impact of aging and Alzheimer's pathology on CNS distribution of the five drugs is insignificant.Pharmacolog
Phase diagram of a superconductor / ferromagnet bilayer
The magnetic field (H) - temperature (T) phase diagram of a superconductor is
significantly altered when domains are present in an underlying ferromagnet
with perpendicular magnetic anisotropy. When the domains have a band-like
shape, the critical temperature Tc of the superconductor in zero field is
strongly reduced, and the slope of the upper critical field as a function of T
is increased by a factor of 2.4 due to the inhomogeneous stray fields of the
domains. Field compensation effects can cause an asymmetric phase boundary with
respect to H when the ferromagnet contains bubble domains. For a very
inhomogeneous domain structure, Tc~H^2 for low H and Tc~H for higher fields,
indicating a dimensional crossover from a one-dimensional network-like to a
two-dimensional behavior in the nucleation of superconductivity.Comment: 6 pages, 7 figure
Generation of entangled states of two atoms inside a leaky cavity
An in-depth theoretical study is carried out to examine the
quasi-deterministic entanglement of two atoms inside a leaky cavity. Two
-type three-level atoms, initially in their ground states, may become
maximally entangled through the interaction with a single photon. By working
out an exact analytic solution, we show that the probability of success depends
crucially on the spectral function of the injected photon. With a cavity
photon, one can generate a maximally entangled state with a certain probability
that is always less than 50%. However, for an injected photon with a narrower
spectral width, this probability can be significantly increased. In particular,
we discover situations in which entanglement can be achieved in a single trial
with an almost unit probability
A global conservation basic income to safeguard biodiversity
Biodiversity conservation supporting a global sustainability transformation must be inclusive, equitable, just and embrace plural values. The conservation basic income (CBI), a proposed unconditional cash transfer to individuals residing in important conservation areas, is a potentially powerful mechanism for facilitating this radical shift in conservation. This analysis provides comprehensive projections for potential gross costs of global CBI using spatial analyses of three plausible future conservation scenarios. Gross costs vary widely, depending on the areas and populations included, from US6.73âtrillion annually. A US478âbillion annually. These costs are large compared with current government conservation spending (~US44âtrillion in global economic production dependent on nature
Dynamic generation of maximally entangled photon multiplets by adiabatic passage
The adiabatic passage scheme for quantum state synthesis, in which atomic
Zeeman coherences are mapped to photon states in an optical cavity, is extended
to the general case of two degenerate cavity modes with orthogonal
polarization. Analytical calculations of the dressed-state structure and Monte
Carlo wave-function simulations of the system dynamics show that, for a
suitably chosen cavity detuning, it is possible to generate states of photon
multiplets that are maximally entangled in polarization. These states display
nonclassical correlations of the type described by Greenberger, Horne, and
Zeilinger (GHZ). An experimental scheme to realize a GHZ measurement using
coincidence detection of the photons escaping from the cavity is proposed. The
correlations are found to originate in the dynamics of the adiabatic passage
and persist even if cavity decay and GHZ state synthesis compete on the same
time scale. Beyond entangled field states, it is also possible to generate
entanglement between photons and the atom by using a different atomic
transition and initial Zeeman state.Comment: 22 pages (RevTeX), including 23 postscript figures. To be published
in Physical Review
Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group
Sulfonylureas, a commonly used class of medication used to treat type 2 diabetes, have been associated with an increased risk of cardiovascular disease. Their effects on QT interval duration and related electrocardiographic phenotypes are potential mechanisms for this adverse effect. In 11 ethnically diverse cohorts that included 71â857 European, African-American and Hispanic/Latino ancestry individuals with repeated measures of medication use and electrocardiogram (ECG) measurements, we conducted a pharmacogenomic genome-wide association study of sulfonylurea use and three ECG phenotypes: QT, JT and QRS intervals. In ancestry-specific meta-analyses, eight novel pharmacogenomic loci met the threshold for genome-wide significance (P<5 Ă 10â8), and a pharmacokinetic variant in CYP2C9 (rs1057910) that has been associated with sulfonylurea-related treatment effects and other adverse drug reactions in previous studies was replicated. Additional research is needed to replicate the novel findings and to understand their biological basis
Precise measurement of hadronic tau-decays with an eta meson
We have studied hadronic tau decay modes involving an eta meson using 490
fb^{-1} of data collected with the Belle detector at the KEKB asymmetric-energy
e+e- collider. The following branching fractions have been measured: B(tau- ->
K- eta nu)=(1.58 +- 0.05 +- 0.09)x 10^{-4}, B(tau- -> K- pi0 eta nu)=(4.6 +-
1.1 +- 0.4)x 10^{-5}, B(tau- -> pi- pi0 eta nu)=(1.35 +- 0.03 +- 0.07)x
10^{-3}, B(tau- -> pi- KS eta nu)=(4.4 +- 0.7 +- 0.2)x 10^{-5}, and B(tau- ->
K^{*-} eta nu)=(1.34 +- 0.12 +- 0.09)x 10^{-4}. These results are substantially
more precise than previous measurements. The new measurements are compared with
theoretical calculations based on the CVC hypothesis or the chiral perturbation
theory. We also set upper limits on branching fractions for tau decays into K-
KS eta nu, pi- KS pi0 eta nu, K- eta eta nu, pi- eta eta nu and non-resonant K-
pi^0 eta nu final states.Comment: 24 pages, 7 figure
Gravitational Coupling and Dynamical Reduction of The Cosmological Constant
We introduce a dynamical model to reduce a large cosmological constant to a
sufficiently small value. The basic ingredient in this model is a distinction
which has been made between the two unit systems used in cosmology and particle
physics. We have used a conformal invariant gravitational model to define a
particular conformal frame in terms of large scale properties of the universe.
It is then argued that the contributions of mass scales in particle physics to
the vacuum energy density should be considered in a different conformal frame.
In this manner, a decaying mechanism is presented in which the conformal factor
appears as a dynamical field and plays a key role to relax a large effective
cosmological constant. Moreover, we argue that this model also provides a
possible explanation for the coincidence problem.Comment: To appear in GR
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