11 research outputs found

    Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

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    Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

    Length of Calving Interval and Average Milk Yield

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    Abstention in Daylight: Strategic Calculus of Voting in the European Parliament

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    As in large elections, substantialabstention is frequently observed inlegislative assemblies. This paper analyzesroll call votes from the third and fourthlegislatures (1989–1999) of the EuropeanParliament to test predictions from threetypes of theories of abstention: (1)decision-theoretic approach of RationalChoice theory, (2) game-theoretic approachof Rational Choice theory, and (3) theSwing Voter’s Curse theory. The resultsindicate that closeness significantlydecreases the rate of abstention. Thefindings also show that an increase in theprobability of being in the majorityincreases turnout. Overall, findings aresupportive of the decision-theoreticapproach of Rational Choice theory butnot of the game-theoretic approach toabstention or the Swing Voter’s Cursetheory. Copyright Kluwer Academic Publishers 2004

    MOLECULAR GENETICS OF ACTIVITY-DEPENDENT STRUCTURAL CHANGES AT THE SYNAPSE

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    Neurotrophic factors in neurodegenerative disorders: Model of parkinson’s disease

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