1,107 research outputs found
Semantic memory is impaired in both dementia with Lewy Bodies (DLB) and dementia of Alzheimer's type (DAT): a comparative neuropsychological study and literature review
OBJECTIVE---To test the hypothesis that semantic impairment is present in both patients with dementia with Lewy bodies (DLB) and those with dementia of Alzheimer's type (DAT).
METHODS---A comprehensive battery of neuropsychological tasks designed to assess semantic memory, visuoperceptual function, verbal fluency, and recognition memory was given to groups of patients with DLB (n=10), DAT (n=10) matched pairwise for age and mini mental state examination (MMSE), and age matched normal controls (n=15).
RESULTS---Both DLB and DAT groups exhibited impaired performance across the range of tasks designed to assess semantic memory. Whereas patients with DAT showed equivalent comprehension of written words and picture stimuli, patients with DLB demonstrated more severe semantic deficits for pictures than words. As in previous studies, patients with DLB but not those with DAT were found to have impaired visuoperceptual functioning. Letter and category fluency were equally reduced for the patients with DLB whereas performance on letter fluency was significantly better in the DAT group. Recognition memory for faces and words was impaired in both groups.
CONCLUSIONS---Semantic impairment is not limited to patients with DAT. Patients with DLB exhibit particular problems when required to access meaning from pictures that is most likely to arise from a combination of semantic and visuoperceptual impairments
Forced Stratified Turbulence: Successive Transitions with Reynolds Number
Numerical simulations are made for forced turbulence at a sequence of
increasing values of Reynolds number, R, keeping fixed a strongly stable,
volume-mean density stratification. At smaller values of R, the turbulent
velocity is mainly horizontal, and the momentum balance is approximately
cyclostrophic and hydrostatic. This is a regime dominated by so-called pancake
vortices, with only a weak excitation of internal gravity waves and large
values of the local Richardson number, Ri, everywhere. At higher values of R
there are successive transitions to (a) overturning motions with local
reversals in the density stratification and small or negative values of Ri; (b)
growth of a horizontally uniform vertical shear flow component; and (c) growth
of a large-scale vertical flow component. Throughout these transitions, pancake
vortices continue to dominate the large-scale part of the turbulence, and the
gravity wave component remains weak except at small scales.Comment: 8 pages, 5 figures (submitted to Phys. Rev. E
The large longitudinal spread of solar energetic particles during the January 17, 2010 solar event
We investigate multi-spacecraft observations of the January 17, 2010 solar
energetic particle event. Energetic electrons and protons have been observed
over a remarkable large longitudinal range at the two STEREO spacecraft and
SOHO suggesting a longitudinal spread of nearly 360 degrees at 1AU. The flaring
active region, which was on the backside of the Sun as seen from Earth, was
separated by more than 100 degrees in longitude from the magnetic footpoints of
each of the three spacecraft. The event is characterized by strongly delayed
energetic particle onsets with respect to the flare and only small or no
anisotropies in the intensity measurements at all three locations. The presence
of a coronal shock is evidenced by the observation of a type II radio burst
from the Earth and STEREO B. In order to describe the observations in terms of
particle transport in the interplanetary medium, including perpendicular
diffusion, a 1D model describing the propagation along a magnetic field line
(model 1) (Dr\"oge, 2003) and the 3D propagation model (model 2) by (Dr\"oge et
al., 2010) including perpendicular diffusion in the interplanetary medium have
been applied, respectively. While both models are capable of reproducing the
observations, model 1 requires injection functions at the Sun of several hours.
Model 2, which includes lateral transport in the solar wind, reveals high
values for the ratio of perpendicular to parallel diffusion. Because we do not
find evidence for unusual long injection functions at the Sun we favor a
scenario with strong perpendicular transport in the interplanetary medium as
explanation for the observations.Comment: The final publication is available at http://www.springerlink.co
Gallavotti-Cohen-Type symmetry related to cycle decompositions for Markov chains and biochemical applications
We slightly extend the fluctuation theorem obtained in \cite{LS} for sums of
generators, considering continuous-time Markov chains on a finite state space
whose underlying graph has multiple edges and no loop. This extended frame is
suited when analyzing chemical systems. As simple corollary we derive in a
different method the fluctuation theorem of D. Andrieux and P. Gaspard for the
fluxes along the chords associated to a fundamental set of oriented cycles
\cite{AG2}.
We associate to each random trajectory an oriented cycle on the graph and we
decompose it in terms of a basis of oriented cycles. We prove a fluctuation
theorem for the coefficients in this decomposition. The resulting fluctuation
theorem involves the cycle affinities, which in many real systems correspond to
the macroscopic forces. In addition, the above decomposition is useful when
analyzing the large deviations of additive functionals of the Markov chain. As
example of application, in a very general context we derive a fluctuation
relation for the mechanical and chemical currents of a molecular motor moving
along a periodic filament.Comment: 23 pages, 5 figures. Correction
How Many CMEs Have Flux Ropes? Deciphering the Signatures of Shocks, Flux Ropes, and Prominences in Coronagraph Observations of CMEs
We intend to provide a comprehensive answer to the question on whether all
Coronal Mass Ejections (CMEs) have flux rope structure. To achieve this, we
present a synthesis of the LASCO CME observations over the last sixteen years,
assisted by 3D MHD simulations of the breakout model, EUV and coronagraphic
observations from STEREO and SDO, and statistics from a revised LASCO CME
database. We argue that the bright loop often seen as the CME leading edge is
the result of pileup at the boundary of the erupting flux rope irrespective of
whether a cavity or, more generally, a 3-part CME can be identified. Based on
our previous work on white light shock detection and supported by the MHD
simulations, we identify a new type of morphology, the `two-front' morphology.
It consists of a faint front followed by diffuse emission and the bright
loop-like CME leading edge. We show that the faint front is caused by density
compression at a wave (or possibly shock) front driven by the CME. We also
present high-detailed multi-wavelength EUV observations that clarify the
relative positioning of the prominence at the bottom of a coronal cavity with
clear flux rope structure. Finally, we visually check the full LASCO CME
database for flux rope structures. In the process, we classify the events into
two clear flux rope classes (`3-part', `Loop'), jets and outflows (no clear
structure). We find that at least 40% of the observed CMEs have clear flux rope
structures. We propose a new definition for flux rope CMEs (FR-CMEs) as a
coherent magnetic, twist-carrying coronal structure with angular width of at
least 40 deg and able to reach beyond 10 Rsun which erupts on a time scale of a
few minutes to several hours. We conclude that flux ropes are a common
occurrence in CMEs and pose a challenge for future studies to identify CMEs
that are clearly not FR-CMEs.Comment: 26 pages, 9 figs, to be published in Solar Physics Topical Issue
"Flux Rope Structure of CMEs
The calibration of the Sudbury Neutrino Observatory using uniformly distributed radioactive sources
The production and analysis of distributed sources of 24Na and 222Rn in the
Sudbury Neutrino Observatory (SNO) are described. These unique sources provided
accurate calibrations of the response to neutrons, produced through
photodisintegration of the deuterons in the heavy water target, and to low
energy betas and gammas. The application of these sources in determining the
neutron detection efficiency and response of the 3He proportional counter
array, and the characteristics of background Cherenkov light from trace amounts
of natural radioactivity is described.Comment: 24 pages, 13 figure
The Paradox of Muscle Hypertrophy in Muscular Dystrophy
Mutations in the dystrophin gene cause Duchenne and Becker muscular dystrophy in humans and syndromes in mice, dogs, and cats. Affected humans and dogs have progressive disease that leads primarily to muscle atrophy. Mdx mice progress through an initial phase of muscle hypertrophy followed by atrophy. Cats have persistent muscle hypertrophy. Hypertrophy in humans has been attributed to deposition of fat and connective tissue (pseudohypertrophy). Increased muscle mass (true hypertrophy) has been documented in animal models. Muscle hypertrophy can exaggerate postural instability and joint contractures. Deleterious consequences of muscle hypertrophy should be considered when developing treatments for muscular dystrophy
The SWAP EUV Imaging Telescope Part I: Instrument Overview and Pre-Flight Testing
The Sun Watcher with Active Pixels and Image Processing (SWAP) is an EUV
solar telescope on board ESA's Project for Onboard Autonomy 2 (PROBA2) mission
launched on 2 November 2009. SWAP has a spectral bandpass centered on 17.4 nm
and provides images of the low solar corona over a 54x54 arcmin field-of-view
with 3.2 arcsec pixels and an imaging cadence of about two minutes. SWAP is
designed to monitor all space-weather-relevant events and features in the low
solar corona. Given the limited resources of the PROBA2 microsatellite, the
SWAP telescope is designed with various innovative technologies, including an
off-axis optical design and a CMOS-APS detector. This article provides
reference documentation for users of the SWAP image data.Comment: 26 pages, 9 figures, 1 movi
Solar cycle variations in the growth and decay of sunspot groups
We analysed the combined Greenwich (1874-1976) and Solar Optical
Observatories Network (1977-2011) data on sunspot groups. The daily rate of
change of the area of a spot group is computed using the differences between
the epochs of the spot group observation on any two consecutive days during its
life-time and between the corrected whole spot areas of the spot group at these
epochs. Positive/negative value of the daily rate of change of the area of a
spot group represents the growth/decay rate of the spot group. We found that
the total amounts of growth and decay of spot groups whose life times > or = 2
days in a given time interval (say one-year) well correlate to the amount of
activity in the same interval. We have also found that there exists a
reasonably good correlation and an approximate linear relationship between the
logarithmic values of the decay rate and area of the spot group at the first
day of the corresponding consecutive days, largely suggesting that a
large/small area (magnetic flux) decreases in a faster/slower rate. There
exists a long-term variation (about 90-year) in the slope of the linear
relationship. The solar cycle variation in the decay of spot groups may have a
strong relationship with the corresponding variations in solar energetic
phenomena such as solar flare activity. The decay of spot groups may also
substantially contribute to the coherence relationship between the total solar
irradiance and the solar activity variations.Comment: 12 pages, 7 figures, Accepted for publication in Astrophysics & Space
Science. arXiv admin note: substantial text overlap with arXiv:1105.106
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