124 research outputs found
Recommended from our members
Potential for entrainment of sodium into expanding multiphase HCDA bubbles by Rayleigh-Taylor instability
The ''termination phase'' of an energetic hypothetical core disruptive accident (HCDA) in liquid-metal fast breeder reactors is characterized by expansion of a high-pressure, high-temperature multiphase bubble against the overlying pool of sodium. A number of entrainment mechanisms have been proposed to explain the entrainment rates observed in various experiments. (JDB
Hamburg's Spaces of Danger: Race, Violence and Memory in a Contemporary Global City
Germany today is experiencing the strongest upsurge of right-wing populism since the second world war, most notably with the rise of Pegida and Alternative fĂŒr Deutschland. Yet wealthy global cities like Hamburg continue to present themselves as the gatekeepers of liberal progress and cosmopolitan openness. This article argues that Hamburgâs urban boosterism relies on, while simultaneously obscuring, the same structures of racial violence that embolden reactionary movements. Drawing on the work of Walter Benjamin and Allan Pred, we present an archaeology of Hamburgâs landscape, uncovering some of its âspaces of dangerâââsites layered with histories of violence, many of which lie buried and forgotten. We find that these spaces, when they become visible, threaten to undermine Hamburgâs cosmopolitan narrative. They must, as a result, be continually erased or downplayed in order to secure the city as an attractive site for capital investment. To illustrate this argument, we give three historical examples: Hamburgâs role in the Hanseatic League during the medieval and early modern period; the city under the Nazi regime; and the recent treatment of Black African refugees. The articleâs main contribution is to better situate issues of historical landscape, collective memory and racialized violence within the political economy of todayâs global city
Genetic Variants in HSD17B3, SMAD3, and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes
Individuals with type 2 diabetes (T2D) and dyslipidemia are at an increased risk of cardiovascular disease. Fibrates are a class of drugs prescribed to treat dyslipidemia, but variation in response has been observed. To evaluate common and rare genetic variants that impact lipid responses to fenofibrate in statin-treated patients with T2D, we examined lipid changes in response to fenofibrate therapy using a genomewide association study (GWAS). Associations were followed-up using gene expression studies in mice. Common variants in SMAD3 and IPO11 were marginally associated with lipid changes in black subjects (P < 5 Ă 10 -6 ). Rare variant and gene expression changes were assessed using a false discovery rate approach. AKR7A3 and HSD17B13 were associated with lipid changes in white subjects (q < 0.2). Mice fed fenofibrate displayed reductions in Hsd17b13 gene expression (q < 0.1). Associations of variants in SMAD3, IPO11, and HSD17B13, with gene expression changes in mice indicate that transforming growth factor-beta (TGF-ÎČ) and NRF2 signaling pathways may influence fenofibrate effects on dyslipidemia in patients with T2D
Hematologic, serum biochemistry and urinary values for captive Crab-eating Fox (Cerdocyon thous) in SĂŁo Paulo state, Brazil
Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A
Untangling outcomes of de jure and de facto community-based management of natural resources
Strategic Planning for Nonprofit Sport Organizations: Empirical Verification of a Framework
- âŠ