Optimization of Neutrino Oscillation Parameters using Differential Evolution

We combine Differential Evolution, a new technique, with the traditional grid based method for optimization of solar neutrino oscillation parameters $\Delta m^2$ and $\tan^{2}\theta$ for the case of two neutrinos. The Differential Evolution is a population based stochastic algorithm for optimization of real valued non-linear non-differentiable objective functions that has become very popular during the last decade. We calculate well known chi-square ($\chi^2$) function for neutrino oscillations for a grid of the parameters using total event rates of chlorine (Homestake), Gallax+GNO, SAGE, Superkamiokande and SNO detectors and theoretically calculated event rates. We find minimum $\chi^2$ values in different regions of the parameter space. We explore regions around these minima using Differential Evolution for the fine tuning of the parameters allowing even those values of the parameters which do not lie on any grid. We note as much as 4 times decrease in $\chi^2$ value in the SMA region and even better goodness-of-fit as compared to our grid-based results. All this indicates a way out of the impasse faced due to CPU limitations of the larger grid method.Comment: 10 pages, 5 figures and 2 table

An X-ray Absorption Edge Detector for High-Resolution Measurement of Undulator Effective K-Parameter

The spectrum of angle-integrated undulator radiation displays a sharp edge at every harmonic photon energy. A technique utilizing this feature to measure minute changes in K-parameters of an undulator in a free-electron laser has been proposed. To date, this technique requires the use of crystal monochromators as bandpass filters whose energy centroid depends on the incident angle of the x-ray beam. In this work we propose to use the absorption edge of an appropriate element as an energy-selective detector whose response is truly independent of the angle of the x-ray beam, and hence independent of electron beam direction and emittance. We will discuss the basic design concept of the detection system and illustrate its projected performance with computer simulations

Development of a multiplex event-specific PCR assay for detection of genetically modified rice

Global rice supplies have been found contaminated with unapproved varieties of genetically modified (GM) rice in recent years, which has led to product recalls in several of countries. Faster and more effective detection of GM contamination can prevent adulterated food, feed and seed from being consumed and grown, minimize the potential environmental, health or economic damage. In this study, a simple, reliable and cost-effective multiplex polymerase chain reaction (PCR) assay for identifying genetic modifications of TT51-1, Kemingdao1 (KMD1) and Kefeng6 (KF6) rice was developed by using the event-specific fragment. The limit of detection (LOD) for each event in the multiplex PCR is approximately 0.1%. Developed multiplex PCR assays can provide a rapid and simultaneous detection of GM rice

First-passage and extreme-value statistics of a particle subject to a constant force plus a random force

We consider a particle which moves on the x axis and is subject to a constant force, such as gravity, plus a random force in the form of Gaussian white noise. We analyze the statistics of first arrival at point $x_1$ of a particle which starts at $x_0$ with velocity $v_0$. The probability that the particle has not yet arrived at $x_1$ after a time $t$, the mean time of first arrival, and the velocity distribution at first arrival are all considered. We also study the statistics of the first return of the particle to its starting point. Finally, we point out that the extreme-value statistics of the particle and the first-passage statistics are closely related, and we derive the distribution of the maximum displacement $m={\rm max}_t[x(t)]$.Comment: Contains an analysis of the extreme-value statistics not included in first versio

Stable vortex and dipole vector solitons in a saturable nonlinear medium

We study both analytically and numerically the existence, uniqueness, and stability of vortex and dipole vector solitons in a saturable nonlinear medium in (2+1) dimensions. We construct perturbation series expansions for the vortex and dipole vector solitons near the bifurcation point where the vortex and dipole components are small. We show that both solutions uniquely bifurcate from the same bifurcation point. We also prove that both vortex and dipole vector solitons are linearly stable in the neighborhood of the bifurcation point. Far from the bifurcation point, the family of vortex solitons becomes linearly unstable via oscillatory instabilities, while the family of dipole solitons remains stable in the entire domain of existence. In addition, we show that an unstable vortex soliton breaks up either into a rotating dipole soliton or into two rotating fundamental solitons.Comment: To appear in Phys. Rev.

Multi-objective inventory routing with uncertain demand using population-based metaheuristics

This article studies a tri-objective formulation of the inventory routing problem, extending the recently studied bi-objective formulation. As compared to distance cost and inventory cost, which were discussed in previous work, it also considers stockout cost as a third objective. Demand is modeled as a Poisson random variable. State-of-the-art evolutionary multi-objective optimization algorithms and a new method based on swarm intelligence are used to compute approximation of the 3-D Pareto front. A benchmark previously used in bi-objective inventory routing is extended by incorporating a stochastic demand model with an expected value that equals the average demand of the original benchmark. The results provide insights into the shape of the optimal trade-off surface. Based on this the dependences between different objectives are clarified and discussed. Moreover, the performances of the four different algorithmic methods are compared and due to the consistency in the results, it can be concluded that a near optimal approximation to the Pareto front can be found for problems of practically relevant size.Algorithms and the Foundations of Software technolog

Soft switching voltage regulation for inductorless piezoelectric transformers: a cyclic mode analysis

This paper describes a novel methodology for predicting the ability of an inductorless driven piezoelectric transformer (PT)-based H-bridge inverters to simultaneously achieve zero-voltage switching and output regulation. A new idea for output voltage regulation by controlling deadtime interval is presented. A model is derived using cyclic-mode analysis to estimate the state-variable parameters of the circuit for a given operating condition. The model is then used to demonstrate operation in the zero-voltage switching (ZVS) region and to estimate the deadtime period, load and operating frequency along the ZVS boundary. The output voltage regulation profile is presented and regions where voltage regulation can be continuously achieved while still obtaining ZVS are shown. Both SPICE simulation and experimental results taken using a ring-dot radial-mode PT are presented as verification. The proposed method for a H-bridge PT-based inverter is able to achieve a 5V output from 15V-60V input with simultaneous ZVS and voltage regulation

The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms.

Background: The modulation of energetic homeostasis by pollutants has recently emerged as a potential contributor to the onset of metabolic disorders. Diethylhexyl phthalate (DEHP) is a widely used industrial plasticizer to which humans are widely exposed. Phthalates can activate the three peroxisome proliferatoractivated receptor (PPAR) isotypes on cellular models and induce peroxisome proliferation in rodents.Objectives: In this study, we aimed to evaluate the systemic and metabolic consequences of DEHP exposure that have remained so far unexplored and to characterize the underlying molecular mechanisms of action.Methods: As a proof of concept and mechanism, genetically engineered mouse models of PPARs were exposed to high doses of DEHP, followed by metabolic and molecular analyses.Results: DEHP-treated mice were protected from diet-induced obesity via PPARalpha-dependent activation of hepatic fatty acid catabolism, whereas the activity of neither PPARbeta nor PPARgamma was affected. However, the lean phenotype observed in response to DEHP in wild-type mice was surprisingly abolished in PPARalpha-humanized mice. These species differences are associated with a different pattern of coregulator recruitment.Conclusion: These results demonstrate that DEHP exerts species-specific metabolic actions that rely to a large extent on PPARalpha signaling and highlight the metabolic importance of the species-specific activation of PPARalpha by xenobiotic compounds. Editor's SummaryDiethylhexyl phthalate (DEHP) is an industrial plasticizer used in cosmetics, medical devices, food packaging, and other applications. Evidence that DEHP metabolites can activate peroxisome proliferatoractivated receptors (PPARs) involved in fatty acid oxidation (PPARalpha and PPARbeta) and adiposite function and insulin resistance (PPARgamma) has raised concerns about potential effects of DEHP on metabolic homeostasis. In rodents, PPARalpha activation also induces hepatic peroxisome proliferation, but this response to PPARalpha activation is not observed in humans. Feige et al. (p. 234) evaluated systemic and metabolic consequences of high-dose oral DEHP in combination with a high-fat diet in wild-type mice and genetically engineered mouse PPAR models. The authors report that mice exposed to DEHP gained less weight than controls, without modifying their feeding behavior; they also exhibited lower triglyceride levels, smaller adipocytes, and improved glucose tolerance compared with controls. These effects, which were observed in mice fed both high-fat and standard diets, appeared to be mediated by PPARalpha-dependent activation of hepatic fatty acid catabolism without apparent involvement of PPARbeta or PPARgamma. However, mouse models that expressed human (versus mouse) PPARalpha tended to gain more weight on a high-fat diet than their DHEP-unexposed counterparts. The authors conclude that findings support species-specific metabolic effects of DEHP mediated by PPARalpha activation

Modeling realistic Earth matter density for CP violation in neutrino oscillation

We examine the effect of a more realistic Earth matter density model which takes into account of the local density variations along the baseline of a possi ble 2100 km very long baseline neutrino oscillation experiment. Its influence to the measurement of CP violation is investigated and a comparison with the commonly used global density models made. Significant differences are found in the comparison of the results of the different density models.Comment: 16 pages, 8 figure