CD4 cell count and the risk of AIDS or death in HIV-Infected adults on combination antiretroviral therapy with a suppressed viral load: a longitudinal cohort study from COHERE.

BACKGROUND: Most adults infected with HIV achieve viral suppression within a year of starting combination antiretroviral therapy (cART). It is important to understand the risk of AIDS events or death for patients with a suppressed viral load. METHODS AND FINDINGS: Using data from the Collaboration of Observational HIV Epidemiological Research Europe (2010 merger), we assessed the risk of a new AIDS-defining event or death in successfully treated patients. We accumulated episodes of viral suppression for each patient while on cART, each episode beginning with the second of two consecutive plasma viral load measurements 500 copies/µl, the first of two consecutive measurements between 50-500 copies/µl, cART interruption or administrative censoring. We used stratified multivariate Cox models to estimate the association between time updated CD4 cell count and a new AIDS event or death or death alone. 75,336 patients contributed 104,265 suppression episodes and were suppressed while on cART for a median 2.7 years. The mortality rate was 4.8 per 1,000 years of viral suppression. A higher CD4 cell count was always associated with a reduced risk of a new AIDS event or death; with a hazard ratio per 100 cells/µl (95% CI) of: 0.35 (0.30-0.40) for counts <200 cells/µl, 0.81 (0.71-0.92) for counts 200 to <350 cells/µl, 0.74 (0.66-0.83) for counts 350 to <500 cells/µl, and 0.96 (0.92-0.99) for counts ≥500 cells/µl. A higher CD4 cell count became even more beneficial over time for patients with CD4 cell counts <200 cells/µl. CONCLUSIONS: Despite the low mortality rate, the risk of a new AIDS event or death follows a CD4 cell count gradient in patients with viral suppression. A higher CD4 cell count was associated with the greatest benefit for patients with a CD4 cell count <200 cells/µl but still some slight benefit for those with a CD4 cell count ≥500 cells/µl

Expressions intégrales de la permittivité complexe associées à la réponse diélectrique universelle

Les auteurs proposent des expressions intégrales permettant de calculer la permittivité complexe associée à la réponse diélectrique universelle, qui évitent le calcul de la fonction hypergéométrique gaussienne au voisinage du point singulier z = 1 dans un domaine où les développements en série habituels convergent lentement

Mesure diélectrique des systèmes diphasiques solide-solution : application à l'activation de la sphalérite par une solution cuivrique

Les auteurs développent un modèle qui décrit le comportement diélectrique d'un milieu hétérogène composé d’un solide divisé peu conducteur en suspension dans une solution ionique, comme base d'une mesure des caractéristiques du solide et d'investigation « in situ » des modifications de l'interface solide-solution apportées par une réaction chimique. Pour en illustrer une application, les auteurs précisent le changement de conductibilité de la sphalérite au cours de son activation par des ions cuivriques

Synthesis of highly oriented CVD diamond films by ultra short bias enhanced nucleation step

International audienc

Ageing impact on tribological properties of MoDTC-containing base oil

International audienc

Friction reduction efficiency of organic Mo-containing FM additives associated to ZDDP for steel and carbon-based contacts

International audienceThe lubricating properties of two different organomolybdenum additives combined with ZDDP were evaluated for different tribopairs involving carbon-based coatings, hydrogenated DLC and nanocrystalline diamond NCD. Their performances were investigated using reciprocating linear tribometer and compared with the traditional additivation MoDTC/ZDDP. The highly sulfurised moly-trimer additive and organic molybdate ester additive displayed good friction reducing properties in comparison with traditional additivation MoDTC for all tribopairs tested, especially organic molybdate ester. XPS and ToF-SIMS surface analyses performed on the tribofilms formed with these different organomolybdenum additives showed the formation of MoS2/MoS2−xOx species exhibiting a solid lubricant character, but preferentially on steel surfaces. HRTEM/EDS analyses confirmed the presence of MoS2/MoS2−xOx sheets embedded inside an oxygen-rich amorphous matrix. This is different from the traditional additivation that leads to the polyphosphate/phosphate glass matrix. Organic molybdate ester is a sulfur- and phosphorus-free additive that appears particularly interesting for achieving low friction while minimizing the S content of the lubricant

Etude dielectrique des mecanismes d'activation et de depression lors de la flottation des minerais sulfures. Cas des solides semiconducteurs

SIGLECNRS RP 440 (140) / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Etude dielectrique des mecanismes d'activation et de depression lors de la flottation des minerais sulfures. Cas des solides semiconducteurs

SIGLECNRS RP 440 (140) / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc