Cholinergic cells in the nucleus basalis of mice express the N-methyl-D-aspartate-receptor subunit NR2C and its replacement by the NR2B subunit enhances frontal and amygdaloid acetylcholine levels

It is known that glutamatergic and cholinergic systems interact functionally at the level of the cholinergic basal forebrain. The N-methyl-D-aspartate receptor (NMDA-R) is a multiprotein complex composed of NR1, NR2 and/or NR3 subunits. The subunit composition of NMDA-R of cholinergic cells in the nucleus basalis has not yet been investigated. Here, by means of choline acetyl transferase and NR2B or NR2C double staining, we demonstrate that mice express both the NR2C and NR2B subunits in nucleus basalis cholinergic cells.We generated NR2C-2B mutant mice in which an insertion of NR2B cDNA into the gene locus of the NR2C gene replaced NR2C by NR2B expression throughout the brain. This NR2C-2B mutant was used to examine whether a subunit exchange in cholinergic neurons would affect acetylcholine (ACh) content in several brain structures. We found increased ACh levels in the frontal cortex and amygdala in the brains of NR2C-2B mutant mice. Brain ACh has been implicated in neuroplasticity, novelty-induced arousal and encoding of novel stimuli. We therefore assessed behavioral habituation to novel environments and objects as well as object recognition in NR2C-2B subunit exchange mice. The behavioral analysis did not indicate any gross behavioral alteration in the mutant mice compared with the wildtype mice. Our results show that the NR2C by NR2B subunit exchange in mice affects ACh content in two target areas of the nucleus basalis.

State transitions in the 2001/2002 outburst of XTE J1650-500

We present a study of the X-ray transient and black hole candidate XTE J1650-500 during its 2001/2002 outburst. The source made two state transitions between the hard and soft states, at luminosity levels that differed by a factor of ~5-10. The first transition, between hard and soft, lasted for ~30 days and showed two parts; one part in which the spectral properties evolve smoothly away from the hard state and another that we identify as the 'steep power law state'. The two parts showed different behavior of the Fe K emission line and QPO frequencies. The second transition, from soft to hard, lasted only \~15 days and showed no evidence of the presence of the 'steep power law state'. Comparing observations from the early rise and the decay of the outburst, we conclude that the source can be in the hard state in a range of more 10^4 in luminosity. We briefly discuss the state transitions in the framework of a two-flow model.Comment: 4 pages, 5 figures. To appear in Proc. of the II BeppoSAX Meeting: "The Restless High-Energy Universe" (Amsterdam, May 5-8, 2003), E.P.J. van den Heuvel, J.J.M. in 't Zand, and R.A.M.J. Wijers Ed

A concise review on THGEM detectors

We briefly review the concept and properties of the Thick GEM (THGEM); it is a robust, high-gain gaseous electron multiplier, manufactured economically by standard printed-circuit drilling and etching technology. Its operation and structure resemble that of GEMs but with 5 to 20-fold expanded dimensions. The millimeter-scale hole-size results in good electron transport and in large avalanche-multiplication factors, e.g. reaching 10^7 in double-THGEM cascaded single-photoelectron detectors. The multiplier's material, parameters and shape can be application-tailored; it can operate practically in any counting gas, including noble gases, over a pressure range spanning from 1 mbar to several bars; its operation at cryogenic (LAr) conditions was recently demonstrated. The high gain, sub-millimeter spatial resolution, high counting-rate capability, good timing properties and the possibility of industrial production capability of large-area robust detectors, pave ways towards a broad spectrum of potential applications; some are discussed here in brief.Comment: 8 pages, 11 figures; Invited Review at INSTR08, Novosibirsk, Feb 28-March 5 200

Scintillation and charge extraction from the tracks of energetic electrons in superfluid helium-4

An energetic electron passing through liquid helium causes ionization along its track. The ionized electrons quickly recombine with the resulting positive ions, which leads to the production of prompt scintillation light. By applying appropriate electric fields, some of the ionized electrons can be separated from their parent ions. The fraction of the ionized electrons extracted in a given applied field depends on the separation distance between the electrons and the ions. We report the determination of the mean electron-ion separation distance for charge pairs produced along the tracks of beta particles in superfluid helium at 1.5 K by studying the quenching of the scintillation light under applied electric fields. Knowledge of this mean separation parameter will aid in the design of particle detectors that use superfluid helium as a target material.Comment: 10 pages, 8 figure

Kahler moduli double inflation

We show that double inflation is naturally realized in K\"ahler moduli inflation, which is caused by moduli associated with string compactification. We find that there is a small coupling between the two inflatons which leads to amplification of perturbations through parametric resonance in the intermediate stage of double inflation. This results in the appearance of a peak in the power spectrum of the primordial curvature perturbation. We numerically calculate the power spectrum and show that the power spectrum can have a peak on observationally interesing scales. We also compute the TT-spectrum of CMB based on the power spectrum with a peak and see that it better fits WMAP 7-years data.Comment: 21 pages, 8 figure

States and transitions in black-hole binaries

With the availability of the large database of black-hole transients from the Rossi X-Ray Timing Explorer, the observed phenomenology has become very complex. The original classification of the properties of these systems in a series of static states sorted by mass accretion rate proved not to be able to encompass the new picture. I outline here a summary of the current situation and show that a coherent picture emerges when simple properties such as X-ray spectral hardness and fractional variability are considered. In particular, fast transition in the properties of the fast time variability appear to be crucial to describe the evolution of black-hole transients. Based on this picture, I present a state-classification which takes into account the observed transitions. I show that, in addition to transients systems, other black-hole binaries and Active Galactic Nuclei can be interpreted within this framework. The association between these states and the physics of the accretion flow around black holes will be possible only through modeling of the full time evolution of galactic transient systems.Comment: 30 pages, 11 figures, To appear in Belloni, T. (ed.): The Jet Paradigm - From Microquasars to Quasars, Lect. Notes Phys. 794 (2009

On the low-temperature performances of THGEM and THGEM/G-APD multipliers in gaseous and two-phase Xe

The performances of THGEM multipliers in two-phase Xe avalanche mode are presented for the first time. Additional results on THGEM operation in gaseous Xe at cryogenic temperatures are provided. Stable operation of a double-THGEM multiplier was demonstrated in two-phase Xe with gains reaching 600. These are compared to existing data, summarized here for two-phase Ar, Kr and Xe avalanche detectors incorporating GEM and THGEM multipliers. The optical readout of THGEMs with Geiger-mode Avalanche Photodiodes (G-APDs) has been investigated in gaseous Xe at cryogenic temperature; avalanche scintillations were recorded in the Near Infrared (NIR) at wavelengths of up to 950 nm. At avalanche charge gain of 350, the double-THGEM/G-APD multiplier yielded 0.07 photoelectrons per initial ionization electron, corresponding to an avalanche scintillation yield of 0.7 NIR photons per avalanche electron over 4pi. The results are compared with those of two-phase Ar avalanche detectors. The advantages, limitations and possible applications are discussed.Comment: 22 pages, 14 figures. Revised Figs. 10,11 and Table 1. To be published in JINS

Accretion and ejection in black-hole X-ray transients

Aims: We summarize the current observational picture of the outbursts of black-hole X-ray transients (BHTs), based on the evolution traced in a hardness-luminosity diagram (HLD), and we offer a physical interpretation. Methods: The basic ingredient in our interpretation is the Poynting-Robertson Cosmic Battery (PRCB, Contopoulos & Kazanas 1998), which provides locally the poloidal magnetic field needed for the ejection of the jet. In addition, we make two assumptions, easily justifiable. The first is that the mass-accretion rate to the black hole in a BHT outburst has a generic bell-shaped form. This is guaranteed by the observational fact that all BHTs start their outburst and end it at the quiescent state. The second assumption is that at low accretion rates the accretion flow is geometrically thick, ADAF-like, while at high accretion rates it is geometrically thin. Results: Both, at the beginning and the end of an outburst, the PRCB establishes a strong poloidal magnetic field in the ADAF-like part of the accretion flow, and this explains naturally why a jet is always present in the right part of the HLD. In the left part of the HLD, the accretion flow is in the form of a thin disk, and such a disk cannot sustain a strong poloidal magnetic filed. Thus, no jet is expected in this part of the HLD. The counterclockwise traversal of the HLD is explained as follows: the poloidal magnetic field in the ADAF forces the flow to remain ADAF and the source to move upwards in the HLD rather than to turn left. Thus, the history of the system determines the counterclockwise traversal of the HLD. As a result, no BHT is expected to ever traverse the entire HLD curve in the clockwise direction. Conclusions: We offer a physical interpretation of accretion and ejection in BHTs with only one parameter, the mass transfer rate.Comment: Accepted for publication in A&