Calibration of the Neutron Detection Efficiency of the COMPTEL NE213 Detector

This research was sponsored by the National Science Foundation Grant NSF PHY 87-1440

Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes pro-survival stimuli to induce apoptosis in chronic lymphocytic leukemia cells

Purpose: Chronic lymphocytic leukemia (CLL) is currently incurable with standard chemotherapeutic agents, highlighting the need for novel therapies. Overcoming proliferative and cytoprotective signals generated within the microenvironment of lymphoid organs is essential for limiting CLL progression and ultimately developing a cure. Experimental Design: We assessed the potency of cyclin-dependent kinase (CDK) inhibitor CR8, a roscovitine analog, to induce apoptosis in primary CLL from distinct prognostic subsets using flow cytometry–based assays. CLL cells were cultured in in vitro prosurvival and proproliferative conditions to mimic microenvironmental signals in the lymphoid organs, to elucidate the mechanism of action of CR8 in quiescent and proliferating CLL cells using flow cytometry, Western blotting, and quantitative real-time PCR. Results: CR8 was 100-fold more potent at inducing apoptosis in primary CLL cells than roscovitine, both in isolated culture and stromal-coculture conditions. Importantly, CR8 induced apoptosis in CD40-ligated CLL cells and preferentially targeted actively proliferating cells within these cultures. CR8 treatment induced downregulation of the antiapoptotic proteins Mcl-1 and XIAP, through inhibition of RNA polymerase II, and inhibition of NF-κB signaling at the transcriptional level and through inhibition of the inhibitor of IκB kinase (IKK) complex, resulting in stabilization of IκBα expression. Conclusions: CR8 is a potent CDK inhibitor that subverts pivotal prosurvival and proproliferative signals present in the tumor microenvironment of CLL patient lymphoid organs. Our data support the clinical development of selective CDK inhibitors as novel therapies for CLL

X-ray streak camera temporal resolution improvement using a longitudinal time-dependent field

X-ray streak cameras (XSC) have been known to be one of the fastest detectors forultrafast X-ray science. A number of applications in material science, biochemistry, accelerator physics, require sub-picosecond resolution to study new phenomena. Inthis paper, we report on a new method which can potentially improve the temporal resolution of a streak camera down to 100 femtoseconds. This method uses a time-dependent acceleration field to lengthen the photoelectron bunch, significantlyimproving the time resolution as well as reducing the time dispersion caused byinitial energy spread and the effects fromthe space charge forces. A computer simulation of an XSC using this method shows significant improvement in the resolution

Progress on modeling of ultrafast x-ray streak cameras

Streak cameras continue to be useful tools for studying phenomena on the picoseconds time scale. We have employed accelerator modeling tools to understand and possibly improve the time resolution of present and future streak cameras. This effort has resulted in an end-to-end model of the camera. This model has contributed to the recent measurement of 230 fsec (FWHM) resolution measured at 266 nm in the Advanced Light Source Streak Camera Laboratory. We describe results from this model that show agreement with the experiments. We also extrapolate the performance of this camera including several possible improvements

Bianchi type II,III and V diagonal Einstein metrics re-visited

We present, for both minkowskian and euclidean signatures, short derivations of the diagonal Einstein metrics for Bianchi type II, III and V. For the first two cases we show the integrability of the geodesic flow while for the third case a somewhat unusual bifurcation phenomenon takes place: for minkowskian signature elliptic functions are essential in the metric while for euclidean signature only elementary functions appear

On Charged Black Holes in Anti-de Sitter Space

We study the region inside the event horizon of charged black holes in five dimensional asymptotically anti-de Sitter space, using as a probe two-sided correlators which are dominated by spacelike geodesics penetrating the horizon. The spacetimes we investigate include the Reissner-Nordstrom black hole and perturbations thereof. The perturbed spacetimes can be found exactly, enabling us to perform a local scan of the region between the inner and outer horizons. Surprisingly, the two-sided correlators we calculate seem to be geometrically protected from the instability of the inner horizon.Comment: 1+37 pages, 20 ps and eps figures, LaTeX. References added and changes made to section

Dynamical Decoupling Using Slow Pulses: Efficient Suppression of 1/f Noise

The application of dynamical decoupling pulses to a single qubit interacting with a linear harmonic oscillator bath with $1/f$ spectral density is studied, and compared to the Ohmic case. Decoupling pulses that are slower than the fastest bath time-scale are shown to drastically reduce the decoherence rate in the $1/f$ case. Contrary to conclusions drawn from previous studies, this shows that dynamical decoupling pulses do not always have to be ultra-fast. Our results explain a recent experiment in which dephasing due to $1/f$ charge noise affecting a charge qubit in a small superconducting electrode was successfully suppressed using spin-echo-type gate-voltage pulses.Comment: 5 pages, 3 figures. v2: Many changes and update

Modular Equations and Distortion Functions

Modular equations occur in number theory, but it is less known that such equations also occur in the study of deformation properties of quasiconformal mappings. The authors study two important plane quasiconformal distortion functions, obtaining monotonicity and convexity properties, and finding sharp bounds for them. Applications are provided that relate to the quasiconformal Schwarz Lemma and to Schottky's Theorem. These results also yield new bounds for singular values of complete elliptic integrals.Comment: 23 page

Sub-terahertz, microwaves and high energy emissions during the December 6, 2006 flare, at 18:40 UT

The presence of a solar burst spectral component with flux density increasing with frequency in the sub-terahertz range, spectrally separated from the well-known microwave spectral component, bring new possibilities to explore the flaring physical processes, both observational and theoretical. The solar event of 6 December 2006, starting at about 18:30 UT, exhibited a particularly well-defined double spectral structure, with the sub-THz spectral component detected at 212 and 405 GHz by SST and microwaves (1-18 GHz) observed by the Owens Valley Solar Array (OVSA). Emissions obtained by instruments in satellites are discussed with emphasis to ultra-violet (UV) obtained by the Transition Region And Coronal Explorer (TRACE), soft X-rays from the Geostationary Operational Environmental Satellites (GOES) and X- and gamma-rays from the Ramaty High Energy Solar Spectroscopic Imager (RHESSI). The sub-THz impulsive component had its closer temporal counterpart only in the higher energy X- and gamma-rays ranges. The spatial positions of the centers of emission at 212 GHz for the first flux enhancement were clearly displaced by more than one arc-minute from positions at the following phases. The observed sub-THz fluxes and burst source plasma parameters were found difficult to be reconciled to a purely thermal emission component. We discuss possible mechanisms to explain the double spectral components at microwaves and in the THz ranges.Comment: Accepted version for publication in Solar Physic