The comparative responsiveness of Hospital Universitario Princesa Index and other composite indices for assessing rheumatoid arthritis activity

Objective To evaluate the responsiveness in terms of correlation of the Hospital Universitario La Princesa Index (HUPI) comparatively to the traditional composite indices used to assess disease activity in rheumatoid arthritis (RA), and to compare the performance of HUPI-based response criteria with that of the EULAR response criteria. Methods Secondary data analysis from the following studies: ACT-RAY (clinical trial), PROAR (early RA cohort) and EMECAR (pre-biologic era long term RA cohort). Responsiveness was evaluated by: 1) comparing change from baseline (Delta) of HUPI with Delta in other scores by calculating correlation coefficients; 2) calculating standardised effect sizes. The accuracy of response by HUPI and by EULAR criteria was analyzed using linear regressions in which the dependent variable was change in global assessment by physician (Delta GDA-Phy). Results Delta HUPI correlation with change in all other indices ranged from 0.387 to 0.791); HUPI's standardized effect size was larger than those from the other indices in each database used. In ACT-RAY, depending on visit, between 65 and 80% of patients were equally classified by HUPI and EULAR response criteria. However, HUPI criteria were slightly more stringent, with higher percentage of patients classified as non-responder, especially at early visits. HUPI response criteria showed a slightly higher accuracy than EULAR response criteria when using Delta GDA-Phy as gold standard. Conclusion HUPI shows good responsiveness in terms of correlation in each studied scenario (clinical trial, early RA cohort, and established RA cohort). Response criteria by HUPI seem more stringent than EULAR''s

7th Drug hypersensitivity meeting: part two

No abstract availabl

Componentes do peso vivo em cordeiros e borregos Polwarth e cruzas Texel x Polwarth Live weight components in Polwarth and Texel x Polwarth lambs and hoggets

O estudo teve por objetivo comparar e quantificar o peso vivo ao abate e seus componentes em cordeiros e borregos Polwarth (Ideal) com cruzas de Texel x ovelhas Polwarth. Foram sacrificados 59 cordeiros com 116 dias de idade, sendo 40 Polwarth (21 machos e 19 fêmeas) e 19 cruzas de Texel x ovelhas Polwarth (7 machos e 12 fêmeas) e 24 borregos com 450 dias de idade, sendo 14 Polwarth e 10 cruzas de Texel x ovelhas Polwarth. Os animais foram criados em condições extensivas de campo nativo ao sul do Brasil (Pelotas-RS) e castrados aos 30 dias de idade. Em termos de valores absolutos, para peso vivo e seus componentes, não se detectaram diferenças significativas entre cordeiros puros e cruzas; para borregos, verificou-se que os cruzas apresentaram maiores pesos (peso vivo ao abate, carcaça quente e fria, cabeça, pulmões com traquéia, fígado, gordura renal e pélvica e rins). Em valores percentuais, foram verificados efeitos significativos entre puros e cruzas, somente em cordeiros, para pele e pulmões com traquéia e, um efeito de sexo para patas e fígado. Os resultados evidenciaram que o cruzamento entre ovelhas Polwarth com Texel, para aumento da produção de carne em condições extensivas de campo nativo, é viável em borregos (maior idade e peso) e não para cordeiros.<br>This work was undertaken to compare and quantify live body weight, at slaughter, and its components of Polwarth and Polwarth x Texel (ram) lambs and hoggets. Fifty-nine lambs (116 days old) were slaughtered. From that, forty were Polwarth (21 males and 19 females) and nineteen were Polwarth x Texel cresses (7 males and 12 females). Also, twenty-four hoggets (450 days old) were slaughtered. Fourteen hoggets were Polwarth and ten Polwarth x Texel cresses. The animals were raised under range conditions on native pasture, in seuthem Brazil (Pelotas-RS), and castrated at 30 days eld. There were no significant diferences, in absolute values, for body weight and its components, among purebred lambs and crosses; for hoggets, the crosses have shown higher weights (live body weight at slaughter, warm and cool carcass, head, lungs plus trachea, liver, kidney plus pelvic fat, and kidney). In percentage values, significant effects were observed among rebred and crosses only with lambs for hide and lungs plus trachea and sex effect for legs and liver. The results have shown that the crossbreeding among Polwarth (ewes) and Texel, for the increment of meat production under range conditions, is possible at a later age and weight (hoggets) but not for lambs

Effectiveness of the combination elvitegravir/cobicistat/tenofovir/emtricitabine (EVG/COB/TFV/FTC) plus darunavir among treatment-experienced patients in clinical practice : A multicentre cohort study

Background: The aim of this study was to investigate the effectiveness and tolerability of the combination elvitegravir/cobicistat/tenofovir/emtricitabine plus darunavir (EVG/COB/TFV/FTC + DRV) in treatment-experienced patients from the cohort of the Spanish HIV/AIDS Research Network (CoRIS). Methods: Treatment-experienced patients starting treatment with EVG/COB/TFV/FTC + DRV during the years 2014-2018 and with more than 24 weeks of follow-up were included. TFV could be administered either as tenofovir disoproxil fumarate or tenofovir alafenamide. We evaluated virological response, defined as viral load (VL) < 50 copies/ml and < 200 copies/ml at 24 and 48 weeks after starting this regimen, stratified by baseline VL (< 50 or ≥ 50 copies/ml at the start of the regimen). Results: We included 39 patients (12.8% women). At baseline, 10 (25.6%) patients had VL < 50 copies/ml and 29 (74.4%) had ≥ 50 copies/ml. Among patients with baseline VL < 50 copies/ml, 85.7% and 80.0% had VL < 50 copies/ml at 24 and 48 weeks, respectively, and 100% had VL < 200 copies/ml at 24 and 48 weeks. Among patients with baseline VL ≥ 50 copies/ml, 42.3% and 40.9% had VL < 50 copies/ml and 69.2% and 68.2% had VL < 200 copies/ml at 24 and 48 weeks. During the first 48 weeks, no patients changed their treatment due to toxicity, and 4 patients (all with baseline VL ≥ 50 copies/ml) changed due to virological failure. Conclusions: EVG/COB/TFV/FTC + DRV was well tolerated and effective in treatment-experienced patients with undetectable viral load as a simplification strategy, allowing once-daily, two-pill regimen with three antiretroviral drug classes. Effectiveness was low in patients with detectable viral loads

AtLAST Science Overview Report

International audienceSubmillimeter and millimeter wavelengths provide a unique view of the Universe, from the gas and dust that fills and surrounds galaxies to the chromosphere of our own Sun. Current single-dish facilities have presented a tantalising view of the brightest (sub-)mm sources, and interferometers have provided the exquisite resolution necessary to analyse the details in small fields, but there are still many open questions that cannot be answered with current facilities. In this report we summarise the science that is guiding the design of the Atacama Large Aperture Submillimeter Telescope (AtLAST). We demonstrate how tranformational advances in topics including star formation in high redshift galaxies, the diffuse circumgalactic medium, Galactic ecology, cometary compositions and solar flares motivate the need for a 50m, single-dish telescope with a 1-2 degree field of view and a new generation of highly multiplexed continuum and spectral cameras. AtLAST will have the resolution to drastically lower the confusion limit compared to current single-dish facilities, whilst also being able to rapidly map large areas of the sky and detect extended, diffuse structures. Its high sensitivity and large field of view will open up the field of submillimeter transient science by increasing the probability of serendipitous detections. Finally, the science cases listed here motivate the need for a highly flexible operations model capable of short observations of individual targets, large surveys, monitoring programmes, target of opportunity observations and coordinated observations with other observatories. AtLAST aims to be a sustainable, upgradeable, multipurpose facility that will deliver orders of magnitude increases in sensitivity and mapping speeds over current and planned submillimeter observatories