Primary Invasive Aspergillosis of the Digestive Tract: Report of Two Cases and Review of the Literature

BACKGROUND: Disseminated aspergillosis is thought to occur as a result of vascular invasion from the lungs with subsequent bloodstream dissemination, and portals of entry other than sinuses and/or the respiratory tract remain speculative. METHODS: We report two cases of primary aspergillosis in the digestive tract and present a detailed review of eight of the 23 previously-published cases for which detailed data are available. RESULTS AND CONCLUSION: These ten cases presented with symptoms suggestive of typhlitis, with further peritonitis requiring laparotomy and small bowel segmental resection. All cases were characterized by the absence of pulmonary disease at the time of histologically-confirmed gastrointestinal involvement with vascular invasion by branched Aspergillus hyphae. These cases suggest that the digestive tract may represent a portal of entry for Aspergillus species in immunocompromised patients

New insights into the genetic etiology of Alzheimer's disease and related dementias.

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Ingénierie écologique et écologie de la restauration : spécificités et complémentarités

International audienceThe origin, objectives and applications of ecological engineering and restoration ecology are different. While the former results from the combination of ecological principles with civil engineers know-how, the latter is the result of scientific approaches. Ecological engineering aims at solving an environmental problem based on a good understanding of the living world as well adapted techniques. Its scope is broad and pragmatic. The purpose of ecological restoration is biodiversity conservation by recover-ing viable communities and functional ecosystems. These ambitious approaches are designed on the medium or long term. Both try to assert their originality through specific networks and communication media, whereas they benefit one from the other.L`origine, les objectifs et les applications de l`ingénierie écologique et de l`écologie de la restauration diffèrent. Si la première est issue de la combinaison de principes écologiques avec le savoir-faire des ingénieurs, la seconde résulte de démarches scientifiques. L`ingénierie écologique vise à résoudre un problème d`environnement à l`aide de connaissances sur le fonctionnement du vivant et de techniques adaptées. Son champ d`intervention est large et pragmatique. La restauration écologique a pour but la sauvegarde de la biodiversité par la récupération de communautés viables et d`écosystèmes fonctionnels. Ces actions ambitieuses se conçoivent à moyen et long terme. Les deux courants cherchent à confirmer leur originalité grâce à des réseaux et supports de diffusion spécifiques, alors qu`ils s`enrichissent l`un l`autre

Ingénierie écologique et écologie de la restauration : spécificités et complémentarités

International audienceThe origin, objectives and applications of ecological engineering and restoration ecology are different. While the former results from the combination of ecological principles with civil engineers know-how, the latter is the result of scientific approaches. Ecological engineering aims at solving an environmental problem based on a good understanding of the living world as well adapted techniques. Its scope is broad and pragmatic. The purpose of ecological restoration is biodiversity conservation by recover-ing viable communities and functional ecosystems. These ambitious approaches are designed on the medium or long term. Both try to assert their originality through specific networks and communication media, whereas they benefit one from the other.L`origine, les objectifs et les applications de l`ingénierie écologique et de l`écologie de la restauration diffèrent. Si la première est issue de la combinaison de principes écologiques avec le savoir-faire des ingénieurs, la seconde résulte de démarches scientifiques. L`ingénierie écologique vise à résoudre un problème d`environnement à l`aide de connaissances sur le fonctionnement du vivant et de techniques adaptées. Son champ d`intervention est large et pragmatique. La restauration écologique a pour but la sauvegarde de la biodiversité par la récupération de communautés viables et d`écosystèmes fonctionnels. Ces actions ambitieuses se conçoivent à moyen et long terme. Les deux courants cherchent à confirmer leur originalité grâce à des réseaux et supports de diffusion spécifiques, alors qu`ils s`enrichissent l`un l`autre

Mammal invaders on islands: impact, control and control impact

International audienc

Mammal invaders on islands: impact, control and control impact

International audienc

Conséquences des introductions d’espèces végétales sur les communautés d’invertébrés terrestres des îles subantarctiques

National audienc