Generalizations of Z-supercontinuous functions and Dδ-supercontinuous functions

[EN] Two new classes of functions, called ‘almost z-supercontinuous functions’ and ’almost Dδ-supercontinuous functions’ are introduced. The class of almost z-supercontinuous functions properly includes the class of z-supercontinuous functions (Indian J. Pure Appl. Math. 33(7), (2002), 1097-1108) as well as the class of almost clopen maps due to Ekici (Acta. Math. Hungar. 107(3), (2005), 193-206) and is properly contained in the class of almost Dδ-supercontinuous functions which in turn constitutes a proper subclass of the class of almost strongly θ-continuous functions due to Noiri and Kang (Indian J. Pure Appl. Math. 15(1), (1984), 1-8) and which in its turn include all δ-continuous functions of Noiri (J. Korean Math. Soc. 16 (1980), 161-166). Characterizations and basic properties of almost z-supercontinuous functions and almost Dδ-supercontinuous functions are discussed and their place in the hierarchy of variants of continuity is elaborated. Moreover, properties of almost strongly θ-continuous functions are investigated and sufficient conditions for almost strongly θ-continuous functions to have u θ-closed (θ-closed) graph are formulated.Kohli, J.; Singh, D.; Kumar, R. (2008). Generalizations of Z-supercontinuous functions and Dδ-supercontinuous functions. Applied General Topology. 9(2):239-251. doi:10.4995/agt.2008.1804.SWORD2392519

Signature Splitting in 7/2 [633]v band of 175Hf

In this paper, we present an explanation of signature splitting observed in the one quasiparticle rotational band (7/2(633)ν) of 175 Hf in terms of one particle plus rotor model (PRM) calculations. The role of angular momentum dependence of the inertia parameter and rotational correction term appearing in Coriolis mixing calculations to explain signature effects is discussed

Identification and characterization of novel factors in the DNA damage response

All cellular organisms contain genomic DNA which provides the instructions for their correct development and functioning. Damage to this DNA may interfere with critical cellular processes such as transcription and replication and has the potential to drive mutagenesis. In turn, this may underlie inherited disorders and accelerate progression of diseases such as cancer and neurodegenerative disorders. The protection of cells and organisms against these devastating effects of DNA damage relies on the DNA damage response (DDR), which comprises a complex network of signaling and repair pathways that coordinate the sensing, signaling and repair of DNA lesions while accommodating suitable adjustments in for instance chromatin structure and cell cycle progression. Not only does the DDR dictate the appropriate repair pathway for several types of DNA damage, including DNA double-strand breaks (DSB), it also modulates replication fork surveillance mechanisms in response to DNA replication stress (RS). While many core proteins have been studied in detail, the full repertoire of factors involved in these pathways remains unknown. Clearly, extending our knowledge on regulators of the DDR will contribute to our understanding of the development, and possibly the treatment, of the numerous disorders that are associated with defects in the DDR. The research described in this thesis has successfully identified and characterized novel factors in DSB repair and the RS response.LUMC / Geneeskund

Master curve in upper region of ductile brittle transition: a modification based on local damage approach

AbstractThe fracture behaviour of ferritic/ferritic martensitic steels in Ductile to Brittle Transition (DBT) region is well captured by Master Curve approach, except in the upper region of transition due to ductile tearing prior to cleavage. The fracture toughness behavior in the upper region of DBT is generally censored by Master Curve. In this work the Master Curve approach is modified to extend its applicability to the upper region of transition. The ductile tearing in the upper region of transition, increased sampled volume and constraint increment are addressed in this work using constraint parameter Tstress and numerical analyses using GTN damage