B(d,s)-anti-B(d,s) mixing and Lepton Flavour Violation in SUSY GUTs: impact of the first measurements of phi(s)

In this work we re-examine the correlation between B(d,s)-anti-B(d,s) mixing and Lepton Flavour Violation in the light of recent experimental measurements in the $B_s$ system. We perform a generic SUSY analysis of the allowed down squark mass insertion parameter space. In the SUSY GUT scenario this parameter space is then used to make predictions for LFV branching ratios. We find that the recent measurement for the CP phase $\phi_s$ excludes the lowest rates for tau --> mu + gamma and provides a lower bound of ~ 3E-9 for tan beta = 10. Future experimental improvements in the bound on tau --> mu + gamma and the measurement of phi(s) will constitute a strong test of the SUSY GUT scenario.Comment: 8 pages, 7 jpeg figures using pdflatex. Version published in Nuclear Physics

Bayesian approach to the assessment of the population-specific risk of inhibitors in hemophilia A patients : A case study

Background: Developing inhibitors is a rare event during the treatment of hemophilia A. The multifacets and uncertainty surrounding the development of inhibitors further complicate the process of estimating inhibitor rate from the limited data. Bayesian statistical modeling provides a useful tool in generating, enhancing, and exploring the evidence through incorporating all the available information. Methods: We built our Bayesian analysis using three study cases to estimate the inhibitor rates of patients with hemophilia A in three different scenarios: Case 1, a single cohort of previously treated patients (PTPs) or previously untreated patients; Case 2, a meta-analysis of PTP cohorts; and Case 3, a previously unexplored patient population - patients with baseline low-titer inhibitor or history of inhibitor development. The data used in this study were extracted from three published ADVATE (antihemophilic factor [recombinant] is a product of Baxter for treating hemophilia A) post-authorization surveillance studies. Noninformative and informative priors were applied to Bayesian standard (Case 1) or random-effects (Case 2 and Case 3) logistic models. Bayesian probabilities of satisfying three meaningful thresholds of the risk of developing a clinical significant inhibitor (10/100, 5/100 [high rates], and 1/86 [the Food and Drug Administration mandated cutoff rate in PTPs]) were calculated. The effect of discounting prior information or scaling up the study data was evaluated. Results: Results based on noninformative priors were similar to the classical approach. Using priors from PTPs lowered the point estimate and narrowed the 95% credible intervals (Case 1: from 1.3 [0.5, 2.7] to 0.8 [0.5, 1.1]; Case 2: from 1.9 [0.6, 6.0] to 0.8 [0.5, 1.1]; Case 3: 2.3 [0.5, 6.8] to 0.7 [0.5, 1.1]). All probabilities of satisfying a threshold of 1/86 were above 0.65. Increasing the number of patients by two and ten times substantially narrowed the credible intervals for the single cohort study (1.4 [0.7, 2.3] and 1.4 [1.1, 1.8], respectively). Increasing the number of studies by two and ten times for the multiple study scenarios (Case 2: 1.9 [0.6, 4.0] and 1.9 [1.5, 2.6]; Case 3: 2.4 [0.9, 5.0] and 2.6 [1.9, 3.5], respectively) had a similar effect. Conclusion: Bayesian approach as a robust, transparent, and reproducible analytic method can be efficiently used to estimate the inhibitor rate of hemophilia A in complex clinical settings

The Geminga Fraction

Radio-quiet gamma-ray pulsars like Geminga may account for a number of the unidentified EGRET sources in the Galaxy. The number of Geminga-like pulsars is very sensitive to the geometry of both the gamma-ray and radio beams. Recent studies of the shape and polarization of pulse profiles of young radio pulsars have provided evidence that their radio emission originates in wide cone beams at altitudes that are a significant fraction (1 -10%) of their light cylinder radius. Such wide radio emission beams will be visible at a much larger range of observer angles than the narrow core components thought to originate at lower altitude. Using 3D geometrical modeling that includes relativistic effects from pulsar rotation, we study the visibility of such radio cone beams as well as that of the gamma-ray beams predicted by slot gap and outer gap models. From the results of this study one can obtain revised predictions for the fraction of Geminga-like, radio quiet pulsars present in the gamma-ray pulsar population

CP violation in Bd,s→l+l−B_{d,s} \to l^+l^- in the model III 2HDM

We have calculated the Wilson coefficients $C_{10}, C_{Q_i}$ (i=1,2) in the $\bar{MS}$ renormalization scheme in the model III 2HDM. Using the obtained Wilson coefficients, we have analyzed the CP violation in decays $B^0_q\to l^+l^-$ (q=d,s) in the model. The CP asymmetry, $A_{CP}$, depends on the parameters of models and $A_{CP}$ in $B_d\to l^+l^-$ can be as large as 40% and 35% for $l=\tau$ and $l=\mu$ respectively. It can reach 4% for $B^0_s$ decays. Because in SM CP violation is smaller than or equal to O($10^{-3}$) which is unobservably small, an observation of CP asymmetry in the decays $B^0_q \to l^+l^- (q=d,s)$ would unambiguously signal the existence of new physics.Comment: revtex4, 16 pages, 7 figure

The hyperon-nucleon interaction: conventional versus effective field theory approach

Hyperon-nucleon interactions are presented that are derived either in the conventional meson-exchange picture or within leading order chiral effective field theory. The chiral potential consists of one-pseudoscalar-meson exchanges and non-derivative four-baryon contact terms. With regard to meson-exchange hyperon-nucleon models we focus on the new potential of the Juelich group, whose most salient feature is that the contributions in the scalar--isoscalar (\sigma) and vector--isovector (\rho) exchange channels are constrained by a microscopic model of correlated \pi\pi and KKbar exchange.Comment: 28 pages, 8 figures, submitted to Lecture Notes in Physic

Short time scale pulse stability of the Crab pulsar in the optical band

The fine structure and the variations of the optical pulse shape and phase of the Crab pulsar are studied on various time scales. The observations have been carried out on 4-m William Hershel and 6-m BTA telescopes with APD photon counter, photomultiplier based 4-channel photometer and PSD based panoramic spectrophotopolarimeter with 1$\mu$s time resolution in 1994, 1999, 2003 and 2005-2006 years. The upper limit on the pulsar precession on Dec 2, 1999 is placed in the 10 s - 2 hours time range. The evidence of a varying from set to set fine structure of the main pulse is found in the 1999 and 2003 years data. No such fine structure is detected in the integral pulse shape of 1994, 1999 and 2003 years. The drastic change of the pulse shape in the 2005-2006 years set is detected along with the pulse shape variability and quasi-periodic phase shifts.Comment: 4 pages, 6 figures. To appear in ApSS, in the proceedings of the conference "Isolated Neutron Stars: from the Interior to the Surface", London, April 2006; eds. D. Page, R. Turolla and S. Zan

Population statistics study of radio and gamma-ray pulsars in the Galactic plane

We present results of our pulsar population synthesis of ordinary isolated and millisecond pulsars in the Galactic plane. Over the past several years, a program has been developed to simulate pulsar birth, evolution and emission using Monte Carlo techniques. We have added to the program the capability to simulate millisecond pulsars, which are old, recycled pulsars with extremely short periods. We model the spatial distribution of the simulated pulsars by assuming that they start with a random kick velocity and then evolve through the Galactic potential. We use a polar cap/slot gap model for $\gamma$-ray emission from both millisecond and ordinary pulsars. From our studies of radio pulsars that have clearly identifiable core and cone components, in which we fit the polarization sweep as well as the pulse profiles in order to constrain the viewing geometry, we develop a model describing the ratio of radio core-to-cone peak fluxes. In this model, short period pulsars are more cone-dominated than in our previous studies. We present the preliminary results of our recent study and the implications for observing these pulsars with GLAST and AGILE.Comment: 6 pages, 3 figures, 1 table, accepted in Astrophysics and Space Scienc

Lepton Flavor Violating Process in Bi-maximal texture of Neutrino Mixings

We investigate the lepton flavor violation in the framework of the MSSM with right-handed neutrinos taking the large mixing angle MSW solution in the quasi-degenerate and the inverse-hierarchical neutrino masses. We predict the branching ratio of $\mu \to e+\gamma$ and $\tau \to \mu+\gamma$ processes assuming the degenerate right-handed Majorana neutrino masses. We find that the branching ratio in the quasi-degenerate neutrino mass spectrum is 100 times smaller than the ones in the inverse-hierarchical and the hierarchical neutrino spectra. We emphasize that the magnitude of $U_{e3}$ is one of important ingredients to predict BR($\mu \to e +\gamma$). The effect of the deviation from the complete-degenerate right-handed Majorana neutrino masses are also estimated. Furtheremore, we examine the S_{3\sL}\times S_{3\sR} model, which gives the quasi-degenerate neutrino masses, and the Shafi-Tavartkiladze model, which gives the inverse-hierarchical neutrino masses. Both predicted branching ratios of $\mu\to e+\gamma$ are smaller than the experimantal bound.Comment: Latex file, 38 pages, 10 figures, revised versio

N-body simulations of gravitational dynamics

We describe the astrophysical and numerical basis of N-body simulations, both of collisional stellar systems (dense star clusters and galactic centres) and collisionless stellar dynamics (galaxies and large-scale structure). We explain and discuss the state-of-the-art algorithms used for these quite different regimes, attempt to give a fair critique, and point out possible directions of future improvement and development. We briefly touch upon the history of N-body simulations and their most important results.Comment: invited review (28 pages), to appear in European Physics Journal Plu

Residue from vacuum ultraviolet irradiation of benzene ices: Insights into the physical structure of astrophysical dust

We have irradiated benzene ices deposited at 4 K on a cold, interstellar dust analog with vacuum ultraviolet (9 eV) irradiation for periods lasting from several hours to nearly a day, after which the irradiated ice was warmed to room temperature. Vacuum ultraviolet photoabsorption spectra of the aromatic residue left at room temperature were recorded and showed the synthesis of benzene derivatives. The residue was also imaged using an electron microscope and revealed crystals of various sizes and shapes. The result of our experiments suggests such geometrically shaped dust particles may be a key component of interstellar dust