Spectrum of the Y=2 Pentaquarks

By assuming a mass formula for the spectrum of the Y=2 pentaquarks, where the chromo-magnetic interaction plays a main role, and identifying the lightest state with the Theta^+(1540), we predict a spectrum in good agreement with the few I=0 and I=1 candidates proposed in the past.Comment: 12 pages, 4 figures, LaTe

Z^* Resonances: Phenomenology and Models

We explore the phenomenology of, and models for, the Z^* resonances, the lowest of which is now well established, and called the Theta. We provide an overview of three models which have been proposed to explain its existence and/or its small width, and point out other relevant predictions, and potential problems, for each. The relation to what is known about KN scattering, including possible resonance signals in other channels, is also discussed.Comment: 29 pages, uses RevTeX4; expanded version (published form

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Analysis of shared heritability in common disorders of the brain

Paroxysmal Cerebral Disorder

Predicting beef carcass composition using tissue weights of a primal cut assessed by computed tomography

8 páginas, 7 tablas, 1 figura.The potential of the composition of the forerib measured by X-ray computed tomography (CT) as a predictor of carcass composition was evaluated using data recorded on 30 Aberdeen Angus and 43 Limousin crossbred heifers and steers. The left sides of the carcasses were split into 20 cuts, which were CT scanned and fully dissected into fat, muscle and bone. Carcass and forerib tissue weights were assessed by dissection and CT. Carcass composition was assessed very accurately by CT scanning of the primal cuts (adj-R-2 = 0.97 for the three tissues). CT scanning predicted weights of fat muscle and bone of the forerib with adj-R-2 of 0.95, 0.91 and 0.75, respectively. Single regression models with the weights of fat muscle or bone in the forerib measured by CT as the only predictors to estimate fat, muscle or bone of the left carcass obtained by CT showed adjusted coefficients of determination (adj-R-2) of 0.79, 0.60 and 0.52, respectively. By additionally fitting breed and sex, accuracy increased to 0.85, 0.73 and 0.67. Using carcass and forerib weights in addition to the previous predictors improved significantly the prediction accuracy of carcass fat and muscle weights to adj-R-2 values of 0.92 and 0.96, respectively, while the highest value for carcass bone weight was 0.77 In general, equations derived using CT data had lower adj-R-2 values for bone, but better accuracies for fat and muscle compared to those obtained using dissection. CT scanning could be considered as an alternative very accurate and fast method to assess beef carcass composition that could be very useful for breeding programmes and research studies involving a large number of animals, including the calibration of other indirect methods (e.g. in vivo and carcass video image analysis).Scottish Government.Peer reviewe

In situ caecal degradation of roughages in horses Degradação cecal in situ de alimentos volumosos em equinos

The present study was carried out to evaluate the in situ degradation of dry matter (DM), neutral detergent fiber (NDF) and crude protein (CP) in roughages by the in situ caecal digestion technique in horses. The roughages evaluated were: Lucerne hay (Medicago sativa), peanut (Arachis pintoi cv. Amarillo), desmodio(Desmodium ovalifolium), stylo (Stylosanthes guianensis cv. Mineirão), pigeon pea (Cajanus cajan), lime-yellow pea (Macrotyloma axillare) and coastcross hay (Cynodon dactylon cv. coastcross). The assay was conducted in a complete randomized design with seven roughages and three replications. One mare with a cannula fitted in the caecum was used, fed diet consisting of coastcross hay (80%) and concentrate (20%) at 2.0% BW, four times a day. Nylon 6.5 × 20 cm bags were used with 45 &#956;/pore, containing 5.2 g DM/bag, inserting 3 or 4 bags in the caecum at the times of 2, 4, 6, 8, 12, 24 and 48 hours incubation. The caecum in situ degradability parameters of nutrients were obtained by Ørskov model. The DM degradability parameters of all the roughages were significant. There was no fit to the model for pigeon pea for CP and NDF and desmodio. Peanut, stylo and lime-yellow pea presented larger potentially degradable DM with values of 53, 46.5 and 40%, respectively, and higher values for the soluble fraction of 20, 21, 28.6%, with high degradability rates of 10.36, 20.26 and 14.8% h-1. Higher NDF degradation rates were observed in these foodstuffs with values of 9.1 and 11.3, 11.2% h-1, high potentially degradable fraction with values of 55, 51.8 and 47.2%, and greater CP degradation at 48 hours with values of 87, 95, and 94.8%. Peanut, stylo and lime-yellow pea presented potential for use in horses diets.<br>Objetivou-se avaliar a degradação da matéria seca (MS), fibra em detergente neutro (FDN) e proteína bruta de alimentos volumosos pela técnica da digestão cecal in situ em equinos. Avaliaram-se as forrageiras: feno de alfafa (Medicago sativa), amendoim forrageiro (Arachis pintoi cv. Amarillo), desmódio (Desmodium ovalifolium), estilosantes (Stylosanthes guianensis cv. Mineirão), guandu (Cajanus cajan), macrotiloma (Macrotyloma axillare) e feno de coastcross (Cynodon dactylon cv. coastcross). O ensaio teve duração de 35 dias e foi realizado em delineamento inteiramente casualizado com sete alimentos e três repetições. Utilizou-se uma égua fistulada no ceco, alimentada com dieta composta por feno de coastcross (80%) e concentrado (20%), fornecida quatro vezes ao dia em quantidade equivalente a 2% do peso vivo. No ceco, foram inseridos 3 a 4 sacos de náilon de porosidade 45 &#956; de 6,5 × 20 cm, contendo 5,2 g de MS/saco, nos tempos de 2, 4, 6, 8, 12, 24 e 48 horas de incubação. Os parâmetros de degradação da MS de todos os volumosos foram significativos. Não houve ajuste no modelo de degradação da PB e FDN do guandu. O amendoim, estilosantes e macrotiloma apresentaram maior fração potencialmente degradável da MS, com valores de 53, 46,5 e 40%, respectivamente, e os maiores valores da fração solúvel de 20, 21, 28,6%, além de elevadas taxas de degradação (10,36, 20,26 e 14,8%h-1). Nestes alimentos, também foram observadas as maiores taxas de degradação da FDN (9,1 e 11,3, 11,2%h-1), das frações potencialmente degradáveis (55, 51,8 e 47,2%) e as mais altas taxas de degradação da PB em 48 horas de incubação (87, 95, 94,8%, respectivamente). O amendoim forrageiro, o estilosantes e o macrotiloma apresentam potencial de uso nas dietas para equinos