296 research outputs found
Site investigation for the effects of vegetation on ground stability
The procedure for geotechnical site investigation is well established but little attention is currently given to investigating the potential of vegetation to assist with ground stability. This paper describes how routine investigation procedures may be adapted to consider the effects of the vegetation. It is recommended that the major part of the vegetation investigation is carried out, at relatively low cost, during the preliminary (desk) study phase of the investigation when there is maximum flexibility to take account of findings in the proposed design and construction. The techniques available for investigation of the effects of vegetation are reviewed and references provided for further consideration. As for general geotechnical investigation work, it is important that a balance of effort is maintained in the vegetation investigation between (a) site characterisation (defining and identifying the existing and proposed vegetation to suit the site and ground conditions), (b) testing (in-situ and laboratory testing of the vegetation and root systems to provide design parameters) and (c) modelling (to analyse the vegetation effects)
A Universal Vertical Stellar Density Distribution Law for the Galaxy
We reduced the observational logarithmic space densities in the vertical
direction up to 8 kpc from the galactic plane, for stars with absolute
magnitudes (5,6], (6,7] and [5,10] in the fields #0952+5245 and SA114, to a
single exponential density law. One of three parameters in the quadratic
expression of the density law corresponds to the local space density for stars
with absolute magnitudes in question. There is no need of any definition for
scaleheights or population types. We confirm with the arguments of non-discrete
thin and thick discs for our Galaxy and propose a single structure up to
several kiloparsecs from the galactic plane. The logarithmic space densities
evaluated by this law for the ELAIS field fit to the observational ones.
Whereas, there are considerable offsets for the logarithmic space densities
produced by two sets of classical galactic model parameters from the
observational ones, for the same field.Comment: 9 pages, 1 figure and 10 tables, accepted for publication in
Astrophysics & Space Scienc
Transformation elastodynamics and active exterior acoustic cloaking
This chapter consists of three parts. In the first part we recall the
elastodynamic equations under coordinate transformations. The idea is to use
coordinate transformations to manipulate waves propagating in an elastic
material. Then we study the effect of transformations on a mass-spring network
model. The transformed networks can be realized with "torque springs", which
are introduced here and are springs with a force proportional to the
displacement in a direction other than the direction of the spring terminals.
Possible homogenizations of the transformed networks are presented, with
potential applications to cloaking. In the second and third parts we present
cloaking methods that are based on cancelling an incident field using active
devices which are exterior to the cloaked region and that do not generate
significant fields far away from the devices. In the second part, the exterior
cloaking problem for the Laplace equation is reformulated as the problem of
polynomial approximation of analytic functions. An explicit solution is given
that allows to cloak larger objects at a fixed distance from the cloaking
device, compared to previous explicit solutions. In the third part we consider
the active exterior cloaking problem for the Helmholtz equation in 3D. Our
method uses the Green's formula and an addition theorem for spherical outgoing
waves to design devices that mimic the effect of the single and double layer
potentials in Green's formula.Comment: Submitted as a chapter for the volume "Acoustic metamaterials:
Negative refraction, imaging, lensing and cloaking", Craster and Guenneau
ed., Springe
Adaptive optics in high-contrast imaging
The development of adaptive optics (AO) played a major role in modern
astronomy over the last three decades. By compensating for the atmospheric
turbulence, these systems enable to reach the diffraction limit on large
telescopes. In this review, we will focus on high contrast applications of
adaptive optics, namely, imaging the close vicinity of bright stellar objects
and revealing regions otherwise hidden within the turbulent halo of the
atmosphere to look for objects with a contrast ratio lower than 10^-4 with
respect to the central star. Such high-contrast AO-corrected observations have
led to fundamental results in our current understanding of planetary formation
and evolution as well as stellar evolution. AO systems equipped three
generations of instruments, from the first pioneering experiments in the
nineties, to the first wave of instruments on 8m-class telescopes in the years
2000, and finally to the extreme AO systems that have recently started
operations. Along with high-contrast techniques, AO enables to reveal the
circumstellar environment: massive protoplanetary disks featuring spiral arms,
gaps or other asymmetries hinting at on-going planet formation, young giant
planets shining in thermal emission, or tenuous debris disks and micron-sized
dust leftover from collisions in massive asteroid-belt analogs. After
introducing the science case and technical requirements, we will review the
architecture of standard and extreme AO systems, before presenting a few
selected science highlights obtained with recent AO instruments.Comment: 24 pages, 14 figure
Gamma Ray Bursts as Probes of Quantum Gravity
Gamma ray bursts (GRBs) are short and intense pulses of -rays
arriving from random directions in the sky. Several years ago Amelino-Camelia
et al. pointed out that a comparison of time of arrival of photons at different
energies from a GRB could be used to measure (or obtain a limit on) possible
deviations from a constant speed of light at high photons energies. I review
here our current understanding of GRBs and reconsider the possibility of
performing these observations.Comment: Lectures given at the 40th winter school of theretical physics:
Quantum Gravity and Phenomenology, Feb. 2004 Polan
Supermassive Binaries and Extragalactic Jets
Some quasars show Doppler shifted broad emission line peaks. I give new
statistics of the occurrence of these peaks and show that, while the most
spectacular cases are in quasars with strong radio jets inclined to the line of
sight, they are also almost as common in radio-quiet quasars. Theories of the
origin of the peaks are reviewed and it is argued that the displaced peaks are
most likely produced by the supermassive binary model. The separations of the
peaks in the 3C 390.3-type objects are consistent with orientation-dependent
"unified models" of quasar activity. If the supermassive binary model is
correct, all members of "the jet set" (astrophysical objects showing jets)
could be binaries.Comment: 31 pages, PostScript, missing figure is in ApJ 464, L105 (see
http://www.aas.org/ApJ/v464n2/5736/5736.html
Discovery and Characterization of Peptide Inhibitors for Calcium and Integrin Binding Protein 1
Calcium and integrin binding protein 1 (CIB1) is an EF-hand-containing, small intracellular protein that has recently been implicated in cancer cell survival and proliferation. In particular, CIB1 depletion significantly impairs tumor growth in triple-negative breast cancer (TNBC). Thus, CIB1 is a potentially attractive target for cancer chemotherapy that has yet to be validated by a chemical probe. To produce a probe molecule to the CIB1 helix 10 (H10) pocket and demonstrate that it is a viable target for molecular intervention, we employed random peptide phage display to screen and select CIB1-binding peptides. The top peptide sequence selected, UNC10245092, was produced synthetically, and binding to CIB1 was confirmed by isothermal titration calorimetry (ITC) and a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. Both assays showed that the peptide bound to CIB1 with low nanomolar affinity. CIB1 was cocrystallized with UNC10245092, and the 2.1 Å resolution structure revealed that the peptide binds as an α-helix in the H10 pocket, displacing the CIB1 C-terminal H10 helix and causing conformational changes in H7 and H8. UNC10245092 was further derivatized with a C-terminal Tat-derived cell penetrating peptide (CPP) to demonstrate its effects on TNBC cells in culture, which are consistent with results of CIB1 depletion. These studies provide a first-in-class chemical tool for CIB1 inhibition in cell culture and validate the CIB1 H10 pocket for future probe and drug discovery efforts
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