369 research outputs found
The ovarian cancer oncobiome.
Humans and other mammals are colonized by microbial agents across the kingdom which can represent a unique microbiome pattern. Dysbiosis of the microbiome has been associated with pathology including cancer. We have identified a microbiome signature unique to ovarian cancers, one of the most lethal malignancies of the female reproductive system, primarily because of its asymptomatic nature during the early stages in development. We screened ovarian cancer samples along with matched, and non-matched control samples using our pan-pathogen array (PathoChip), combined with capture-next generation sequencing. The results show a distinct group of viral, bacterial, fungal and parasitic signatures of high significance in ovarian cases. Further analysis shows specific viral integration sites within the host genome of tumor samples, which may contribute to the carcinogenic process. The ovarian cancer microbiome signature provides insights for the development of targeted therapeutics against ovarian cancers
Applicability of perturbative QCD to decays
We develop perturbative QCD factorization theorem for the semileptonic heavy
baryon decay , whose form factors are
expressed as the convolutions of hard quark decay amplitudes with universal
and baryon wave functions. Large logarithmic
corrections are organized to all orders by the Sudakov resummation, which
renders perturbative expansions more reliable. It is observed that perturbative
QCD is applicable to decays for velocity transfer
greater than 1.2. Under requirement of heavy quark symmetry, we predict the
branching ratio , and determine
the and baryon wave functions.Comment: 12 pages in Latex file, 3 figures in postscript files, some results
are changed, but the conclusion is the sam
Sub-terahertz, microwaves and high energy emissions during the December 6, 2006 flare, at 18:40 UT
The presence of a solar burst spectral component with flux density increasing
with frequency in the sub-terahertz range, spectrally separated from the
well-known microwave spectral component, bring new possibilities to explore the
flaring physical processes, both observational and theoretical. The solar event
of 6 December 2006, starting at about 18:30 UT, exhibited a particularly
well-defined double spectral structure, with the sub-THz spectral component
detected at 212 and 405 GHz by SST and microwaves (1-18 GHz) observed by the
Owens Valley Solar Array (OVSA). Emissions obtained by instruments in
satellites are discussed with emphasis to ultra-violet (UV) obtained by the
Transition Region And Coronal Explorer (TRACE), soft X-rays from the
Geostationary Operational Environmental Satellites (GOES) and X- and gamma-rays
from the Ramaty High Energy Solar Spectroscopic Imager (RHESSI). The sub-THz
impulsive component had its closer temporal counterpart only in the higher
energy X- and gamma-rays ranges. The spatial positions of the centers of
emission at 212 GHz for the first flux enhancement were clearly displaced by
more than one arc-minute from positions at the following phases. The observed
sub-THz fluxes and burst source plasma parameters were found difficult to be
reconciled to a purely thermal emission component. We discuss possible
mechanisms to explain the double spectral components at microwaves and in the
THz ranges.Comment: Accepted version for publication in Solar Physic
High-Energy Aspects of Solar Flares: Overview of the Volume
In this introductory chapter, we provide a brief summary of the successes and
remaining challenges in understanding the solar flare phenomenon and its
attendant implications for particle acceleration mechanisms in astrophysical
plasmas. We also provide a brief overview of the contents of the other chapters
in this volume, with particular reference to the well-observed flare of 2002
July 23Comment: This is the introductory article for a monograph on the physics of
solar flares, inspired by RHESSI observations. The individual articles are to
appear in Space Science Reviews (2011
Epidemiological investigation of a case of nosocomial Legionnaires' disease in Taiwan: implications for routine environmental surveillance
AbstractAn epidemiological investigation with Legionella and molecular subtyping was conducted to determine the source of a case of nosocomial Legionnaires' disease (LD) who was hospitalized in three hospitals within a month. Legionella pneumophila serogroup 3, an uncommon serogroup for infection, was isolated from the patient's sputum. Environmental surveillance revealed Legionella colonization in all three hospitals; the patient isolate matched the isolate from the first hospital by molecular typing. Culturing the hospital water supply for Legionella is a pro-active strategy for detection of nosocomial LD even in hospitals experiencing no previous cases
Giant Shapiro steps for two-dimensional Josephson-junction arrays with time-dependent Ginzburg-Landau dynamics
Two-dimensional Josephson junction arrays at zero temperature are
investigated numerically within the resistively shunted junction (RSJ) model
and the time-dependent Ginzburg-Landau (TDGL) model with global conservation of
current implemented through the fluctuating twist boundary condition (FTBC).
Fractional giant Shapiro steps are found for {\em both} the RSJ and TDGL cases.
This implies that the local current conservation, on which the RSJ model is
based, can be relaxed to the TDGL dynamics with only global current
conservation, without changing the sequence of Shapiro steps. However, when the
maximum widths of the steps are compared for the two models some qualitative
differences are found at higher frequencies. The critical current is also
calculated and comparisons with earlier results are made. It is found that the
FTBC is a more adequate boundary condition than the conventional uniform
current injection method because it minimizes the influence of the boundary.Comment: 6 pages including 4 figures in two columns, final versio
Imaging Spectroscopy of a White-Light Solar Flare
We report observations of a white-light solar flare (SOL2010-06-12T00:57,
M2.0) observed by the Helioseismic Magnetic Imager (HMI) on the Solar Dynamics
Observatory (SDO) and the Reuven Ramaty High-Energy Solar Spectroscopic Imager
(RHESSI). The HMI data give us the first space-based high-resolution imaging
spectroscopy of a white-light flare, including continuum, Doppler, and magnetic
signatures for the photospheric FeI line at 6173.34{\AA} and its neighboring
continuum. In the impulsive phase of the flare, a bright white-light kernel
appears in each of the two magnetic footpoints. When the flare occurred, the
spectral coverage of the HMI filtergrams (six equidistant samples spanning
\pm172m{\AA} around nominal line center) encompassed the line core and the blue
continuum sufficiently far from the core to eliminate significant Doppler
crosstalk in the latter, which is otherwise a possibility for the extreme
conditions in a white-light flare. RHESSI obtained complete hard X-ray and
\Upsilon-ray spectra (this was the first \Upsilon-ray flare of Cycle 24). The
FeI line appears to be shifted to the blue during the flare but does not go
into emission; the contrast is nearly constant across the line profile. We did
not detect a seismic wave from this event. The HMI data suggest stepwise
changes of the line-of-sight magnetic field in the white-light footpoints.Comment: 14 pages, 7 figures, Accepted by Solar Physic
Logarithmic Corrections to Rotating Extremal Black Hole Entropy in Four and Five Dimensions
We compute logarithmic corrections to the entropy of rotating extremal black
holes using quantum entropy function i.e. Euclidean quantum gravity approach.
Our analysis includes five dimensional supersymmetric BMPV black holes in type
IIB string theory on T^5 and K3 x S^1 as well as in the five dimensional CHL
models, and also non-supersymmetric extremal Kerr black hole and slowly
rotating extremal Kerr-Newmann black holes in four dimensions. For BMPV black
holes our results are in perfect agreement with the microscopic results derived
from string theory. In particular we reproduce correctly the dependence of the
logarithmic corrections on the number of U(1) gauge fields in the theory, and
on the angular momentum carried by the black hole in different scaling limits.
We also explain the shortcomings of the Cardy limit in explaining the
logarithmic corrections in the limit in which the (super)gravity description of
these black holes becomes a valid approximation. For non-supersymmetric
extremal black holes, e.g. for the extremal Kerr black hole in four dimensions,
our result provides a stringent testing ground for any microscopic explanation
of the black hole entropy, e.g. Kerr/CFT correspondence.Comment: LaTeX file, 50 pages; v2: added extensive discussion on the relation
between boundary condition and choice of ensemble, modified analysis for
slowly rotating black holes, all results remain unchanged, typos corrected;
v3: minor additions and correction
Density Waves in Layered Systems with Fermionic Polar Molecules
A layered system of two-dimensional planes containing fermionic polar
molecules can potentially realize a number of exotic quantum many-body states.
Among the predictions, are density-wave instabilities driven by the anisotropic
part of the dipole-dipole interaction in a single layer. However, in typical
multilayer setups it is reasonable to expect that the onset and properties of a
density-wave are modified by adjacent layers. Here we show that this is indeed
the case. For multiple layers the critical strength for the density-wave
instability decreases with the number of layers. The effect depends on density
and is more pronounced in the low density regime. The lowest solution of the
instability corresponds to the density waves in the different layers being
in-phase, whereas higher solutions have one or several adjancet layers that are
out of phase. The parameter regime needed to explore this instability is within
reach of current experiments.Comment: 7 pages, 4 figures. Final version in EPJD, EuroQUAM special issue
"Cold Quantum Matter - Achievements and Prospects
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