130 research outputs found
Will the recently approved LARES mission be able to measure the Lense-Thirring effect at 1%?
After the approval by the Italian Space Agency of the LARES satellite, which
should be launched at the end of 2009 with a VEGA rocket and whose claimed goal
is a about 1% measurement of the general relativistic gravitomagnetic
Lense-Thirring effect in the gravitational field of the spinning Earth, it is
of the utmost importance to reliably assess the total realistic accuracy that
can be reached by such a mission. The observable is a linear combination of the
nodes of the existing LAGEOS and LAGEOS II satellites and of LARES able to
cancel out the impact of the first two even zonal harmonic coefficients of the
multipolar expansion of the classical part of the terrestrial gravitational
potential representing a major source of systematic error. While LAGEOS and
LAGEOS II fly at altitudes of about 6000 km, LARES will be placed at an
altitude of 1450 km. Thus, it will be sensitive to much more even zonals than
LAGEOS and LAGEOS II. Their corrupting impact \delta\mu has been evaluated by
using the standard Kaula's approach up to degree L=70 along with the sigmas of
the covariance matrices of eight different global gravity solutions
(EIGEN-GRACE02S, EIGEN-CG03C, GGM02S, GGM03S, JEM01-RL03B, ITG-Grace02s,
ITG-Grace03, EGM2008) obtained by five institutions (GFZ, CSR, JPL, IGG, NGA)
with different techniques from long data sets of the dedicated GRACE mission.
It turns out \delta\mu about 100-1000% of the Lense-Thirring effect. An
improvement of 2-3 orders of magnitude in the determination of the high degree
even zonals would be required to constrain the bias to about 1-10%.Comment: Latex, 15 pages, 1 table, no figures. Final version matching the
published one in General Relativity and Gravitation (GRG
Phenomenology of the Lense-Thirring effect in the Solar System
Recent years have seen increasing efforts to directly measure some aspects of
the general relativistic gravitomagnetic interaction in several astronomical
scenarios in the solar system. After briefly overviewing the concept of
gravitomagnetism from a theoretical point of view, we review the performed or
proposed attempts to detect the Lense-Thirring effect affecting the orbital
motions of natural and artificial bodies in the gravitational fields of the
Sun, Earth, Mars and Jupiter. In particular, we will focus on the evaluation of
the impact of several sources of systematic uncertainties of dynamical origin
to realistically elucidate the present and future perspectives in directly
measuring such an elusive relativistic effect.Comment: LaTex, 51 pages, 14 figures, 22 tables. Invited review, to appear in
Astrophysics and Space Science (ApSS). Some uncited references in the text
now correctly quoted. One reference added. A footnote adde
An Assessment of the Systematic Uncertainty in Present and Future Tests of the Lense-Thirring Effect with Satellite Laser Ranging
We deal with the attempts to measure the Lense-Thirring effect with the
Satellite Laser Ranging (SLR) technique applied to the existing LAGEOS and
LAGEOS II terrestrial satellites and to the recently approved LARES
spacecraft.The first issue addressed here is: are the so far published
evaluations of the systematic uncertainty induced by the bad knowledge of the
even zonal harmonic coefficients J_L of the multipolar expansion of the Earth's
geopotential reliable and realistic?
Our answer is negative. Indeed, if the differences Delta J_L among the even
zonals estimated in different Earth's gravity field global solutions from the
dedicated GRACE mission are assumed for the uncertainties delta J_L instead of
using their covariance sigmas sigma_JL, it turns out that the systematic
uncertainty \delta\mu in the Lense-Thirring test with the nodes Omega of LAGEOS
and LAGEOS II may be up to 3 to 4 times larger than in the evaluations so far
published () based on the use of the sigmas of one model at a time
separately. The second issue consists of the possibility of using a different
approach in extracting the relativistic signature of interest from the
LAGEOS-type data. The third issue is the possibility of reaching a realistic
total accuracy of 1% with LAGEOS, LAGEOS II and LARES, which should be launched
in November 2009 with a VEGA rocket. While LAGEOS and LAGEOS II fly at
altitudes of about 6000 km, LARES will be likely placed at an altitude of 1450
km. Thus, it will be sensitive to much more even zonals than LAGEOS and LAGEOS
II. Their corrupting impact has been evaluated with the standard Kaula's
approach up to degree L=60 by using Delta J_L and sigma_JL; it turns out that
it may be as large as some tens percent.Comment: LaTex, 19 pages, 1 figure, 12 tables. Invited and refereed
contribution to The ISSI Workshop, 6-10 October 2008, on The Nature of
Gravity Confronting Theory and Experiment in Space To appear in Space Science
Review
Emergence and maintenance of actionable genetic drivers at medulloblastoma relapse
Background
Less than 5% of medulloblastoma (MB) patients survive following failure of contemporary radiation-based therapies. Understanding the molecular drivers of medulloblastoma relapse (rMB) will be essential to improve outcomes. Initial genome-wide investigations have suggested significant genetic divergence of the relapsed disease.
Methods
We undertook large-scale integrated characterization of the molecular features of rMB—molecular subgroup, novel subtypes, copy number variation (CNV), and driver gene mutation. 119 rMBs were assessed in comparison with their paired diagnostic samples (n = 107), alongside an independent reference cohort sampled at diagnosis (n = 282). rMB events were investigated for association with outcome post-relapse in clinically annotated patients (n = 54).
Results
Significant genetic evolution occurred over disease-course; 40% of putative rMB drivers emerged at relapse and differed significantly between molecular subgroups. Non-infant MBSHH displayed significantly more chromosomal CNVs at relapse (TP53 mutation-associated). Relapsed MBGroup4 demonstrated the greatest genetic divergence, enriched for targetable (eg, CDK amplifications) and novel (eg, USH2A mutations) events. Importantly, many hallmark features of MB were stable over time; novel subtypes (>90% of tumors) and established genetic drivers (eg, SHH/WNT/P53 mutations; 60% of rMB events) were maintained from diagnosis. Critically, acquired and maintained rMB events converged on targetable pathways which were significantly enriched at relapse (eg, DNA damage signaling) and specific events (eg, 3p loss) predicted survival post-relapse.
Conclusions
rMB is characterised by the emergence of novel events and pathways, in concert with selective maintenance of established genetic drivers. Together, these define the actionable genetic landscape of rMB and provide a basis for improved clinical management and development of stratified therapeutics, across disease-course
On realcompact topological vector spaces
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Mitigating risk of exceeding environmental limits requires ambitious food system interventions
Transforming the global food system is necessary to avoid exceeding planetary boundaries. A robust evidence base is crucial to assess the scale and combination of interventions required for a sustainable transformation. We developed a risk assessment framework, underpinned by a meta-regression of 60 global food system modeling studies, to quantify the potential of individual and combined interventions to mitigate the risk of exceeding the boundaries for land-system change, freshwater use, climate change, and biogeochemical flows by 2050. Limiting the risk of exceedance across four key planetary boundaries requires a high but plausible level of ambition in all demand-side (diet, population, waste) and most supply-side interventions. Attaining the required level of ambition for all interventions relies on embracing synergistic actions across the food system
Stoichiometry and doping in large gap compound semiconductors
Current theoretical models on self-compensation in large gap semiconductors assume that intrinsic stoichiometric defects dominate and explain electrical properties quite satisfactorily without any contribution from impurities. Some recent results show on the contrary that impurities are in fact dominant at least at room temperature. The paper, starting from one particular material (ZnTe), is an attempt to understand the real physico-chemistry of self-compensation and the reasons for the success of simplified theories assuming the crystal to be very pure.Les théories courantes sur l'autocompensation des semiconducteurs composés à large bande interdite (travaux de Kröger en particulier) qui font appel à l'intervention de défauts de stœchiométrie expliquent relativement bien les propriétés électriques sans intervention des impuretés. Un certain nombre de résultats récents montrent au contraire que celles-ci jouent en fait un rôle déterminant au moins à température ambiante. On tentera de comprendre qualitativement, à partir d'un matériau particulier (ZnTe), la physicochimie réelle de l'autocompensation et les raisons du succès apparent des théories simplifiées qui supposent le cristal pur
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