Nonlinear parametric instability in double-well lattices

A possibility of a nonlinear resonant instability of uniform oscillations in dynamical lattices with harmonic intersite coupling and onsite nonlinearity is predicted. Numerical simulations of a lattice with a double-well onsite anharmonic potential confirm the existence of the nonlinear instability with an anomalous value of the corresponding power index, 1.57, which is intermediate between the values 1 and 2 characterizing the linear and nonlinear (quadratic) instabilities. The anomalous power index may be a result of competition between the resonant quadratic instability and nonresonant linear instabilities. The observed instability triggers transition of the lattice into a chaotic dynamical state.Comment: A latex text file and three pdf files with figures. Physical Review E, in pres

ICER is requisite for Th17 differentiation.

Inducible cAMP early repressor (ICER) has been described as a transcriptional repressor isoform of the cAMP response element modulator (CREM). Here we report that ICER is predominantly expressed in Th17 cells through the IL-6-STAT3 pathway and binds to the Il17a promoter, where it facilitates the accumulation of the canonical enhancer RORγt. In vitro differentiation from naive ICER/CREM-deficient CD4(+) T cells to Th17 cells is impaired but can be rescued by forced overexpression of ICER. Consistent with a role of Th17 cells in autoimmune and inflammatory diseases, ICER/CREM-deficient B6.lpr mice are protected from developing autoimmunity. Similarly, both anti-glomerular basement membrane-induced glomerulonephritis and experimental encephalomyelitis are attenuated in ICER/CREM-deficient mice compared with their ICER/CREM-sufficient littermates. Importantly, we find ICER overexpressed in CD4(+) T cells from patients with systemic lupus erythematosus. Collectively, our findings identify a unique role for ICER, which affects both organ-specific and systemic autoimmunity in a Th17-dependent manner

Noise-enhanced propagation in a dissipative chain of triggers

International audienceWe study the influence of spatiotemporal noise on the propagation of square waves in an electrical dissipative chain of triggers. By numerical simulation, we show that noise plays an active role in improving signal transmission. Using the Signal to Noise Ratio at each cell, we estimate the propagation length. It appears that there is an optimum amount of noise that maximizes this length. This specific case of stochastic resonance shows that noise enhances propagation

Analysis and numerical modelling of large-scale controls on aquifer structure and hydrogeological properties in the African basement (Benin, West Africa)

The metamorphic basement units of the Upper Oueme watershed in Benin have been investigated to identify the structural controls on aquifer properties, groundwater flow and water balance at large scale. Spatial analysis of borehole and hydrogeophysical data suggests that large-scale weathering profiles, aquifer transmissivity and storage properties are better correlated to a palaeo-weathering surface. Multi-model analysis, combined with assessment of nine transient numerical groundwater models against observations, suggests the best conceptualizations are those where hydraulic conductivity and specific yield are distributed within a weathered zone determined through interpolation of weathered zone thickness. When compared to previous studies, the general groundwater balance of simulated models suggests the groundwater system contributes, on average, 49.8 m(3) s(-1) to the river flow (mostly during the rainy season). The same volumetric flow would be lost to groundwater evapo-transpiration and deep/lateral drainage of the catchment. Borehole abstraction (about 7.5 m(3) s(-1)) represents only 6% of the average groundwater recharge and 1% of the average rainfall. This suggests that despite relatively low borehole productivity, the basement aquifer system still has an important unused potential for rural to mid-scale water supply and that, at present, the main external drivers for groundwater resource sustainability are changes in climate and land use

SLE-Associated Defects Promote Altered T Cell Function.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease linked to profound defects in the function and phenotype of T lymphocytes. Here, we describe abnormal signaling pathways that have been documented in T cells from patients with SLE and discuss how they impact gene expression and immune function, in order to understand how they contribute to disease development and progression

Intra-particle oxygen diffusion limitation in solid-state fermentation

Oxygen limitation in solid-state fermentation (SSF) has been the topic of modeling studies, but thus far, there has been no experimental elucidation on oxygen-transfer limitation at the particle level. Therefore, intra-particle oxygen transfer was experimentally studied in cultures of Rhizopus oligosporus grown on the surface of solid, nutritionally defined, glucose and starch media. The fungal mat consisted of two layers - an upper layer with sparse aerial hyphae and gas-filled interstitial pores, and a dense bottom layer with liquid-filled pores. During the course of cultivation ethanol was detected in the medium indicating that oxygen was depleted in part of the fungal mat. Direct measurement of the oxygen concentrations in the fungal mat during cultivation, using oxygen microelectrodes, showed no oxygen depletion in the upper aerial layer, but revealed development of steep oxygen concentration gradients in the wet bottom layer. Initially, the fungal mat was fully oxygenated, but after 36.5 hours oxygen was undetectable at 100 m below the gas-liquid interface. This was consistent with the calculated oxygen penetration depth using a reaction-diffusion model. Comparison of the overall oxygen consumption rate from the gas phase to the oxygen flux at the gas-liquid interface showed that oxygen consumption of the microorganisms occurred mainly in the wet part of the fungal mat. The contribution of the aerial hyphae to overall oxygen consumption was negligible. It can be concluded that optimal oxygen transfer in SSF depends on the available interfacial gas-liquid surface area and the thickness of the wet fungal layer. It is suggested that the moisture content of the matrix affects both parameters and, therefore, plays an important role in optimizing oxygen transfer in SSF culture

Dataset on onshore groundwaters and offshore submarine spring of a Mediterranean karst aquifer during flow reversal and saltwater intrusion

Groundwater from various shallow and deep reservoirs converges in interaction with marine waters into the limestone aquifer of the Balaruc peninsula (Thau lagoon, southern France). This aquifer faces temporary phenomena of marine water intrusion through the Vise submarine spring located at −29.5 m below the lagoon level. Since the 1960s, seven flow reversal phenomena have occurred, the last one occurring between 11/28/2020 and 03/14/2022. During these phenomena, which can last from a few weeks to several months, the salty water is absorbed from the lagoon to the conduit of the submarine spring, which leads to the salinization of the underlying karst aquifer. The monitoring of flow, water specific conductivity and water temperature data from the karst submarine spring is a key element of the research project to understand the hydrogeological functioning of the karst aquifer under normal conditions or during flow reversal periods. This monitoring allows the characterization of the (in- or out-) flows at the submarine spring, the evaluation of the volume or mass balances, the identification of the hydrogeological and physico-chemical responses (water temperature, specific conductivity) observed within the karstic aquifer. Here, we present the means implemented offshore to acquire data at the submarine spring over the 06/25/2019 - 12/31/2022 time period together with lagoon water's physico-chemical parameters and levels and onshore groundwater's physico-chemical parameters and levels acquired at springs and boreholes from the karst aquifer

Intra-particle oxygen diffusion limitation in solid-state fermentation

Oxygen limitation in solid-state fermentation (SSF) has been the topic of modeling studies, but thus far, there has been no experimental elucidation on oxygen-transfer limitation at the particle level. Therefore, intra-particle oxygen transfer was experimentally studied in cultures of Rhizopus oligosporus grown on the surface of solid, nutritionally defined, glucose and starch media. The fungal mat consisted of two layers - an upper layer with sparse aerial hyphae and gas-filled interstitial pores, and a dense bottom layer with liquid-filled pores. During the course of cultivation ethanol was detected in the medium indicating that oxygen was depleted in part of the fungal mat. Direct measurement of the oxygen concentrations in the fungal mat during cultivation, using oxygen microelectrodes, showed no oxygen depletion in the upper aerial layer, but revealed development of steep oxygen concentration gradients in the wet bottom layer. Initially, the fungal mat was fully oxygenated, but after 36.5 hours oxygen was undetectable at 100 m below the gas-liquid interface. This was consistent with the calculated oxygen penetration depth using a reaction-diffusion model. Comparison of the overall oxygen consumption rate from the gas phase to the oxygen flux at the gas-liquid interface showed that oxygen consumption of the microorganisms occurred mainly in the wet part of the fungal mat. The contribution of the aerial hyphae to overall oxygen consumption was negligible. It can be concluded that optimal oxygen transfer in SSF depends on the available interfacial gas-liquid surface area and the thickness of the wet fungal layer. It is suggested that the moisture content of the matrix affects both parameters and, therefore, plays an important role in optimizing oxygen transfer in SSF culture