Synthesis, Characterization and Antifungal Studies of Some Metronidazole Complexes

Some transition metal complexes of metronidazole (met) have been prepared from the metal halide salt and the ligand at mole ratio 1:2. These complexes have been characterized by vibrational, electronics, HNMR and Atomic absorption spectroscopy. The antifungal activities of the ligand and its complexes are also described. The analysis of the spectroscopic data suggests that the ligand is bidentate in its mode of coordination and the structure of the complex is four coordinate

Synthesis, Characterization and Antimicrobial Study Of Mixed Isoniazid-Trimethoprim Metal Drug Complexes

The Mn2+, Fe2+, Cu2+, Co2+, Zn2+, Cd2+ complexes of mixed  of Trimethoprim- Isoniazid were synthesized. The complexes were characterized using solubility, melting point, conductivity measurement and infrared spectroscopy.Trimethoprim complexes of coordination of the metal to the ligands is through the nitrogen of the pyrimidine group and coordination through the nitrogen of the amine group. The antimicrobial activity of the complexes were carried out against Staphylococcus aureus, Pseudomonas aureginosa, Klebsiella pneumonia, Escherichia coli. The results show that the complexes were more active  than their ligands. Keywords: Trimethoprim, Isoniazid, synthesis, complexes, characterized, antimicrobial ligands metal

Synthesis, Characterization and Antifungal Studies of Some Metronidazole Complexes

Some transition metal complexes of metronidazole (met) have been prepared from the metal halide salt and the ligand at mole ratio 1:2. These complexes have been characterized by vibrational, electronics, HNMR and Atomic absorption spectroscopy. The antifungal activities of the ligand and its complexes are also described. The analysis of the spectroscopic data suggests that the ligand is bidentate in its mode of coordination and the structure of the complex is four coordinate

Heteroleptic Transition Metal Complexes of Eflornithine Hydrochloride Monohydrate: Synthesis, Characterization, in silico and in vitro Biological Studies

Incessant development of resistance to drugs by microorganisms remains a major setback associated with the currently available antibiotics, thereby making imperative a continuous search for alternative candidates with improved efficacy. Previous studies have shown enhanced antimicrobial activity of some bioactive molecules upon coordination with metal ions. Thus, in this study, Cu(II), Co(II), and Ni(II) complexes of eflornithine hydrochloride monohydrate (EHM) were synthesized and probed for bactericidal activity via in vitro and in silico. The characterization results such as CHN analysis, FTIR, UV-visible magnetic susceptibility and Electrospray Ionization Mass Spectrometry (ESI-MS) reveal that EHM coordinates as a bidentate ligand to each central metal ion in the molar ratio 1:2 through O and N in the COO- and NH2 group respectively, and also suggest octahedral geometry in each complex. The physicochemical and pharmacokinetics parameters predicted in silico support the bio-applicability and safety of the complexes. From the in vitro antibacterial study, the complexes demonstrate improved activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa with an average minimum inhibitory concentration (MIC) of 0.01 mg/L similar to ciprofloxacin, compared to EHM whose MIC >1.00 mg/L. Although, not all the complexes satisfy Lipinski’s drugability rule of 5 due to their molecular weight, however, coordination with metal ions improves the biological activities of EHM and the complexes demonstrate potential for further transformation into antibiotic therapeutics. © 2022, Turkish Chemical Society. All rights reserved.Tertiary Education Trust Fund, TETFundThe authors gratefully acknowledge the financial support from the World Bank Science and Technology Education Post-Basic Project (STEP-B) TETFUND, Department of Chemistry University of Ilorin, Nigeria and also Tetfund Nigeria for PhD scholarship awarded to YOA

Synthesis, Characterization and Antimicrobial Activities of Some Nicotinamide \u2013 metal

Some transition metal complexes of nicotinamide have been prepared and characterized using melting point, conductivity measurement, infrared, electronic, HNMR and atomic absorption spectroscopic methods. The antibacterial and antifungal studies of the metal complexes and the ligand have been evaluated against Escherichia coli , Staphylococcus and Bacillus subtilis , Aspergillus flavus , Aspergillus niger and penicillum species. It was found that nicotinamide formed stable metal complexes with these metal ions. The analysis of the spectroscopic data shows that nicotinamide act as monodentate, coordinating through the nitrogen atom of the pyridine ring. All the complexes exhibit 4- coordinate geometry. The results of the antimicrobial studies showed that the metal complexes have higher inhibitory activity than the original nicotinamide against the tested bacteria and fungi species