INSPIRED Symposium Part 4B: Chimeric Antigen Receptor T Cell Correlative Studies-Established Findings and Future Priorities.

Chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of B cell malignancies, with multiple CAR T cell products approved for numerous indications by regulatory agencies worldwide. However, significant work remains to be done to enhance these treatments. In March 2023, a group of experts in CAR T cell therapy assembled at the National Institutes of Health in Bethesda, Maryland at the Insights in Pediatric CAR T Cell Immunotherapy: Recent Advances and Future Directions (INSPIRED) Symposium to identify key areas for research for the coming years. In session 4B, correlative studies to be incorporated into future clinical trials and real-world settings were discussed. Active areas of research identified included (1) optimizing CAR T cell product manufacturing; (2) ensuring adequate lymphodepletion prior to CAR T cell administration; (3) overcoming immunoregulatory cells and tumor stroma present in the tumor microenvironment, particularly in solid tumors; (4) understanding tumor intrinsic properties that lead to CAR T cell immunotherapy resistance; and (5) uncovering biomarkers predictive of treatment resistance, treatment durability, or immune-related adverse events. Here we review the results of previously published clinical trials and real-world studies to summarize what is currently known about each of these topics. We then outline priorities for future research that we believe will be important for improving our understanding of CAR T cell therapy and ultimately leading to better outcomes for patients

Underwriting profit margin of P/L insurance in the fuzzy-ICAPM

The ICAPM is used to study the underwriting profit margin of the P/L insurance company, including the insurances of automobile damage, automobile liability and fire, in which the parameters are the symmetric or non-symmetric triangular fuzzy numbers. From the ten-year data of a company in Taiwan we determine the lower and upper limits associated with the various α-level of the fuzzy numbers. Our results show that the best-fitting parameters of the model from our data are the asymmetric triangular fuzzy numbers. The skew factors in each insurance are determined, which could be used to perform the forecasting of the underwriting profit margin. Our results show that the systematic risk in the fuzzy environment (with best-fitting value of skew factor) becomes larger than that in the crisp environment. However, the insurance underwriting leverage and insurance financial leverage in the fuzzy environment are smaller than those in the crisp environment. Copyright Springer Science + Business Media, LLC 2006Underwriting profit margin, Insurance capital asset pricing model, Fuzzy set theory,

Adaptations for teaching social work with groups in the age of technology

This practice-based paper will describe experiences teaching social work with groups using technological enhancements. Examples from undergraduate social work education will be used to describe approaches employed in two courses in social groupwork; one which is conducted fully online and the second which employs a multi-modal format, conducted primarily online but with a required in-class component. Recommendations for teaching groupwork practice using online technology will be presented