916 research outputs found
Waveguide mode imaging and dispersion analysis with terahertz near-field microscopy
Propagation of terahertz waves in hollow metallic waveguides depends on the waveguide mode. Near-field scanning probe terahertz microscopy is applied to identify the mode structure and composition in dielectric-lined hollow metallic waveguides. Spatial profiles, relative amplitudes, and group velocities of three main waveguide modes are experimentally measured and matched to the HE11, HE12, and TE11 modes. The combination of near-field microscopy with terahertz time-resolved spectroscopy opens the possibility of waveguide mode characterization in the terahertz band
Role of shear stress in endothelial cell morphology and expression of cyclooxygenase isoforms
MEDLINEŸ is the source for the MeSH terms of this document.Objective-: The goal of this study was to examine the effect of chronic heterogeneous shear stress, applied using an orbital shaker, on endothelial cell morphology and the expression of cyclooxygenases 1 and 2. Methods and results-: Porcine aortic endothelial cells were plated on fibronectin-coated Transwell plates. Cells were cultured for up to 7 days either under static conditions or on an orbital shaker that generated a wave of medium inducing shear stress over the cells. Cells were fixed and stained for the endothelial surface marker CD31 or cyclooxygenases 1 and 2. En face confocal microscopy and scanning ion conductance microscopy were used to show that endothelial cells were randomly oriented at the center of the well, aligned with shear stress nearer the periphery, and expressed cyclooxygenase-1 under all conditions. Lipopolysaccharide induced cyclooxygenase-2 and the production of 6-keto-prostaglandin F1α in all cells. Conclusion-: Cyclooxygenase-1 is expressed in endothelial cells cultured under chronic shear stress of high or low directionality.Peer reviewedSubmitted Versio
Light and Life: Exotic Photosynthesis in Binary Star Systems
The potential for hosting photosynthetic life on Earth-like planets within
binary/multiple stellar systems was evaluated by modelling the levels of
photosynthetically active radiation (PAR) such planets receive. Combinations of
M and G stars in: (i) close-binary systems; (ii) wide-binary systems and (iii)
three-star systems were investigated and a range of stable radiation
environments found to be possible. These environmental conditions allow for the
possibility of familiar, but also more exotic forms of photosynthetic life,
such as infrared photosynthesisers and organisms specialised for specific
spectral niches.Comment: Accepted for publication in: Astrobiolog
OC-0257: NTCP models for acute dysphagia resulting from (chemo)radiotherapy for head and neck cancer
The Gross-Neveu Model from String Theory
We study an intersecting D-brane model which at low energies describes
(1+1)-dimensional chiral fermions localized at defects on a stack of N_c
D4-branes. Fermions at different defects interact via exchange of massless
(4+1)-dimensional fields. At weak coupling this interaction gives rise to the
Gross-Neveu (GN) model and can be studied using field theoretic techniques. At
strong coupling one can describe the system in terms of probe branes
propagating in a curved background in string theory. The chiral symmetry is
dynamically broken at zero temperature and is restored above a critical
temperature T_c which depends on the coupling. The phase transition at T_c is
first order at strong coupling and second order at weak coupling.Comment: 32 pages, harvmac (b
Warming, euxinia and sea level rise during the PaleoceneâEocene Thermal Maximum on the Gulf Coastal Plain: implications for ocean oxygenation and nutrient cycling
The PaleoceneâEocene Thermal Maximum(PETM, ?56 Ma) was a ?200 kyr episode of globalwarming, associated with massive injections of 13C-depletedcarbon into the oceanâatmosphere system. Although climatechange during the PETM is relatively well constrained,effects on marine oxygen concentrations and nutrientcycling remain largely unclear. We identify the PETM in asediment core from the US margin of the Gulf of Mexico.Biomarker-based paleotemperature proxies (methylationof branched tetraetherâcyclization of branched tetraether(MBTâCBT) and TEX86) indicate that continental air andsea surface temperatures warmed from 27â29 to ?35 ?C,although variations in the relative abundances of terrestrialand marine biomarkers may have influenced these estimates.Vegetation changes, as recorded from pollen assemblages,support this warming.The PETM is bracketed by two unconformities. It overliesPaleocene silt- and mudstones and is rich in angular(thus in situ produced; autochthonous) glauconite grains,which indicate sedimentary condensation. A drop in the relativeabundance of terrestrial organic matter and changesin the dinoflagellate cyst assemblages suggest that risingsea level shifted the deposition of terrigenous material landward.This is consistent with previous findings of eustatic sealevel rise during the PETM. Regionally, the attribution of theglauconite-rich unit to the PETM implicates the dating of aprimate fossil, argued to represent the oldest North Americanspecimen on record.The biomarker isorenieratene within the PETM indicatesthat euxinic photic zone conditions developed, likely seasonally,along the Gulf Coastal Plain. A global data compilationindicates that O2 concentrations dropped in allocean basins in response to warming, hydrological change,and carbon cycle feedbacks. This culminated in (seasonal)anoxia along many continental margins, analogous to moderntrends. Seafloor deoxygenation and widespread (seasonal)anoxia likely caused phosphorus regeneration fromsuboxic and anoxic sediments.We argue that this fueled shelfeutrophication, as widely recorded from microfossil studies,increasing organic carbon burial along many continentalPublished by Copernicus Publications on behalf of the European Geosciences Union.Warming, euxinia and sea level rise during the PETMmargins as a negative feedback to carbon input and globalwarming. If properly quantified with future work, the PETMoffers the opportunity to assess the biogeochemical effects ofenhanced phosphorus regeneration, as well as the timescaleson which this feedback operates in view of modern and futureocean deoxygenation
A Simple Model of Liquid-liquid Phase Transitions
In recent years, a second fluid-fluid phase transition has been reported in
several materials at pressures far above the usual liquid-gas phase transition.
In this paper, we introduce a new model of this behavior based on the
Lennard-Jones interaction with a modification to mimic the different kinds of
short-range orientational order in complex materials. We have done Monte Carlo
studies of this model that clearly demonstrate the existence of a second
first-order fluid-fluid phase transition between high- and low-density liquid
phases
Transiting Exoplanets with JWST
The era of exoplanet characterization is upon us. For a subset of exoplanets
-- the transiting planets -- physical properties can be measured, including
mass, radius, and atmosphere characteristics. Indeed, measuring the atmospheres
of a further subset of transiting planets, the hot Jupiters, is now routine
with the Spitzer Space Telescope. The James Webb Space Telescope (JWST) will
continue Spitzer's legacy with its large mirror size and precise thermal
stability. JWST is poised for the significant achievement of identifying
habitable planets around bright M through G stars--rocky planets lacking
extensive gas envelopes, with water vapor and signs of chemical disequilibrium
in their atmospheres. Favorable transiting planet systems, are, however,
anticipated to be rare and their atmosphere observations will require tens to
hundreds of hours of JWST time per planet. We review what is known about the
physical characteristics of transiting planets, summarize lessons learned from
Spitzer high-contrast exoplanet measurements, and give several examples of
potential JWST observations.Comment: 22 pages, 11 figures. In press in "Astrophysics in the Next Decade:
JWST and Concurrent Facilities, Astrophysics & Space Science Library,
Thronson, H. A., Tielens, A., Stiavelli, M., eds., Springer: Dordrecht
(2008)." The original publication will be available at
http://www.springerlink.co
Expression profiles of adult T-cell leukemia-lymphoma and associations with clinical responses to zidovudine and interferon alpha
Adult T-cell leukemia-lymphoma (ATLL) is an HTLV-1-associated lymphoproliferative malignancy that is frequently fatal. We compared gene expression profiles (GEPs) of leukemic specimens from nine patients with ATLL at the time of diagnosis and immediately after combination therapy with zidovudine (AZT) and interferon alpha (IFNalpha). GEPs were also related to genetic aberrations determined by comparative genomic hybridization. We identified several genes anomalously over-expressed in the ATLL leukemic cells at the mRNA level, including LYN, CSPG2, and LMO2, and confirmed LMO2 expression in ATLL cells at the protein level. In vivo AZT-IFNalpha therapy evoked a marked induction of interferon-induced genes accompanied by repression of cell-cycle regulated genes, including those encoding ribosomal proteins. Remarkably, patients not responding to AZT-IFNalpha differed most from responding patients in lower expression of these same IFN-responsive genes, as well as components of the antigen processing and presentation apparatus. Demonstration of specific gene expression signatures associated with response to AZT-IFNalpha therapy may provide novel insights into the mechanisms of action in ATLL
ADHM/Nahm Construction of Localized Solitons in Noncommutative Gauge Theories
We study the relationship between ADHM/Nahm construction and ``solution
generating technique'' of BPS solitons in noncommutative gauge theories.
ADHM/Nahm construction and ``solution generating technique'' are the most
strong ways to construct exact BPS solitons. Localized solitons are the
solitons which are generated by the ``solution generating technique.'' The
shift operators which play crucial roles in ``solution generating technique''
naturally appear in ADHM/Nahm construction and we can construct various exact
localized solitons including new solitons: localized periodic instantons
(=localized calorons) and localized doubly-periodic instantons. Nahm
construction also gives rise to BPS fluxons straightforwardly from the
appropriate input Nahm data which is expected from the D-brane picture of BPS
fluxons. We also show that the Fourier-transformed soliton of the localized
caloron in the zero-period limit exactly coincides with the BPS fluxon.Comment: 30 pages, LaTeX, 3 figures; v3: minor changes, references added; v4:
references added, version to appear in PR
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