High-Order Discontinuous Galerkin Method for Boltzmann Model Equations

High-order Runge-Kutta discontinuous Galerkin (DG) method is applied to the kinetic model equations describing rarefied gas flows. A conservative DG discretization of nonlinear collision relaxation term is formulated for Bhatnagar-Gross-Krook and ellipsoidal statistical models. The numerical solutions using RKDG method of order up to four are obtained for two flow problems: the heat transfer between parallel plates and the normal shock wave. The convergence of RKDG method is compared with the conventional secondorder finite volume method for the heat transfer problem. The normal shock wave solutions obtained using RKDG are compared with the experimental measurements of density and velocity distribution function inside the shock

Prognostic significance of delirium subtypes in critically ill medical and surgical patients:a secondary analysis of a prospective multicenter study

BACKGROUND: The prognostic implication of delirium subtypes in critically ill medical and surgical patients is scarcely investigated. The objective was to determine how delirium subtypes are associated with hospital mortality and other clinical outcomes. METHODS: We performed a secondary analysis on data from a prospective multicenter study aimed at implementation of delirium-oriented measures, conducted between 2012 and 2015 in The Netherlands. We included adults (≥ 18 years) admitted to the medical or surgical intensive care unit (ICU). Exclusion criteria were neurological admission diagnosis, persistent coma or ICU readmissions. Delirium was assessed using the Confusion Assessment Method-ICU or Intensive Care Delirium Screening Checklist, and delirium subtypes (hypoactive, hyperactive, or mixed) were classified using the Richmond Agitation–Sedation Scale. The main outcome was hospital mortality. Secondary outcomes were ICU mortality, ICU length of stay, coma, mechanical ventilation, and use of antipsychotics, sedatives, benzodiazepines and opioids. RESULTS: Delirium occurred in 381 (24.4%) of 1564 patients (52.5% hypoactive, 39.1% mixed, 7.3% hyperactive). After case-mix adjustment, patients with mixed delirium had higher hospital mortality than non-delirious patients (OR 3.09, 95%CI 1.79–5.33, p = 0.001), whereas hypoactive patients did not (OR 1.34, 95%CI 0.71–2.55, p = 0.37). Similar results were found for ICU mortality. Compared to non-delirious patients, both subtypes had longer ICU stay, more coma, increased mechanical ventilation frequency and duration, and received more antipsychotics, sedatives, benzodiazepines and opioids. Except for coma and benzodiazepine use, the most unfavourable outcomes were observed in patients with mixed delirium. CONCLUSIONS: Patients with mixed delirium had the most unfavourable outcomes, including higher mortality, compared with no delirium. These differences argue for distinguishing delirium subtypes in clinical practice and future research. Trial registration ClinicalTrials.gov NCT01952899. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40560-022-00644-1

Magnetic structure in Dy/Sc superlattices

We have investigated magnetic order in superlattices of Dy and Sc grown along the hcp c axis by molecular beam epitaxy (MBE) techniques. Our neutron diffraction experiments reveal that individual Dy layers order ferromagnetically below Tc∼150 K. The magnetic coherence length along the growth direction is less than the Dy-layer thickness. Previous studies of rare-earth superlattices with Y or Lu as spacer layers have shown that magnetic coherence propagates through sufficiently thin nonmagnetic interlayers. This arises from the long-range exchange interaction that originates from nesting features in the Fermi surface of the spacer material. The lack of coupling in Dy/Sc superlattices reflects the very different Fermi surface of Sc, with much weaker nesting than Y and Lu

Anisotropic magnetic behavior in Dy/Y films and superlattices

By neutron diffraction we show that superlattices of Dy and Y grown by molecular-beam epitaxy along the hcp b axis exhibit little magnetic coupling between successive Dy layers, even for Y spacers as thin as 9 atomic planes (26). Previous studies of Dy/Y superlattices grown along the hcp c axis established that long-range three-dimensional helimagnetic ordering takes place even through Y spacer layers as thick as 120. This highly anisotropic coupling behavior is shown to have its origin in nearly-two-dimensional nesting features of the Y and Dy Fermi surfaces. Nesting along the c axis gives rise to sharp peaks along c in the wave-vector-dependent magnetic susceptibility, and causes the exchange coupling to exhibit long-range oscillations in real space. The lack of nesting features along the b axis leaves a rapid exponential decay of the exchange interaction with spin separation. From magnetic measurements by superconducting-quantum-interference-device magnetometry on b-axis superlattices and films, we deduce that the first-order ferromagnetic transition of Dy is suppressed, and that the critical field required to produce the ferromagnetic alignment is much higher than the c-axis counterpart. This difference arises from anisotropy of the energy balance of the system. The magnetic coherence in b-axis superlattices and films is anisotropic and exhibits an unusual temperature dependence

Wide Angle Polarization Analysis with Neutron Spin Filters

AbstractWe report substantial improvements in a compact wide angle neutron spin filter system that was recently employed on the Multi- Axis Crystal Spectrometer at the Center for Neutron Research at the U.S. National Institute of Standards and Technology. The apparatus consists of a cylindrical 3He polarizer cell and wide-angle 3He analyzer cells, a vertical solenoid to provide a uniform magnetic field, and a shielded radio-frequency solenoid for the polarizer cell. Nuclear magnetic resonance is employed to reverse the polarization in the polarizer cell and monitor the 3He polarization in all cells. The first experiment using this apparatus was carried out with cylindrical analyzer cells with limited angular coverage due to low polarizations in fused quartz cells. We present results for aluminosilicate glass analyzer cells that cover 110 ∘ and have long relaxation times (100h to 400h). Using two 100W diode bars spectrally narrowed with chirped volume Bragg gratings, we have obtained 65% - 80% 3He polarization in these cells. The 3He polarization has been measured by neutron transmission and electron paramagnetic resonance. Additional progress includes an improved holding field solenoid and decreased spin-flip losses

Explanation for the increase in high altitude water on Mars observed by NOMAD during the 2018 global dust storm

The Nadir and Occultation for MArs Discovery (NOMAD) instrument on board ExoMars Trace Gas Orbiter (TGO) measured a large increase in water vapor at altitudes in the range of 40‐100 km during the 2018 global dust storm on Mars. Using a three‐dimensional general circulation model, we examine the mechanism responsible for the enhancement of water vapor in the upper atmosphere. Experiments with different prescribed vertical profiles of dust show that when more dust is present higher in the atmosphere the temperature increases and the amount of water ascending over the tropics is not limited by saturation until reaching heights of 70‐100 km. The warmer temperatures allow more water to ascend to the mesosphere. Photochemical simulations show a strong increase in high‐altitude atomic hydrogen following the high‐altitude water vapor increase by a few days

Pharmacological activation of LXR alters the expression profile of tumor-associated macrophages and the abundance of regulatory T cells in the tumor microenvironment

Liver X receptors (LXR) are transcription factors from the nuclear receptor family that are activated by oxysterols and synthetic high-affinity agonists. In this study, we assessed the anti-tumor effects of synthetic LXR agonist TO901317 in a murine model of syngeneic Lewis Lung carcinoma. Treatment with TO901317 inhibited tumor growth in wild-type but not in LXR-deficient mice, indicating that the anti-tumor effects of the agonist depends on functional LXR activity in host cells. Pharmacological activation of the LXR pathway reduced the intratumoral abundance of regulatory T cells (Treg) and the expression of the Treg-attracting chemokine Ccl17 by MHCIIhigh tumor-associated macrophages (TAM). Moreover, gene expression profiling indicated a broad negative impact of the LXR agonist on other mechanisms used by TAM for the maintenance of an immunosuppressive environment. In studies exploring the macrophage response to GM-CSF or IL-4, activated LXR repressed IRF4 expression, resulting in subsequent downregulation of IRF4-dependent genes including Ccl17. Taken together, this work reveals the combined actions of the LXR pathway in the control of TAM responses that contribute to the anti-tumoral effects of pharmacological LXR activation. Moreover, these data provide new insights for the development of novel therapeutic options for the treatment of cancer

Topological String Amplitudes, Complete Intersection Calabi-Yau Spaces and Threshold Corrections

We present the most complete list of mirror pairs of Calabi-Yau complete intersections in toric ambient varieties and develop the methods to solve the topological string and to calculate higher genus amplitudes on these compact Calabi-Yau spaces. These symplectic invariants are used to remove redundancies in examples. The construction of the B-model propagators leads to compatibility conditions, which constrain multi-parameter mirror maps. For K3 fibered Calabi-Yau spaces without reducible fibers we find closed formulas for all genus contributions in the fiber direction from the geometry of the fibration. If the heterotic dual to this geometry is known, the higher genus invariants can be identified with the degeneracies of BPS states contributing to gravitational threshold corrections and all genus checks on string duality in the perturbative regime are accomplished. We find, however, that the BPS degeneracies do not uniquely fix the non-perturbative completion of the heterotic string. For these geometries we can write the topological partition function in terms of the Donaldson-Thomas invariants and we perform a non-trivial check of S-duality in topological strings. We further investigate transitions via collapsing D5 del Pezzo surfaces and the occurrence of free Z2 quotients that lead to a new class of heterotic duals.Comment: 117 pages, 1 Postscript figur

The outer disks of galaxies: "To be or not to be truncated?"

We have in recent years come to view the outer parts of galaxies as having vital clues about their formation and evolution. Here, we would like to briefly present our results from a complete sample of nearby, late-type, spiral galaxies, using data from the SDSS survey, especially focused on the stellar light distribution in the outer disk. Our study shows that only the minority of late-type galaxies show a classical, exponential Freeman Type I profile down to the noise limit, whereas the majority exhibit either downbending (stellar truncation as introduced 1979 by Piet van der Kruit) or upbending profiles.Comment: LaTeX, 6 pages. To appear in the proceedings of the "Island Universes: Structure and Evolution of Disk Galaxies" conference held in Terschelling, Netherlands, July 2005, ed. R. de Jong (Springer: Dordrecht