Incidencia del ejercicio físico y el entrenamiento vibratorio sobre la amplitud de movimiento de mujeres con fibromialgia

ResumenObjetivoEn la presente investigación hemos planteado como objetivos principales, por un lado, valorar el efecto del ejercicio físico y el entrenamiento vibratorio sobre la amplitud de movimiento en mujeres con fibromialgia (FM) y, por otro, determinar si existe alguna relación entre dicha variable y el dolor y la rigidez.MétodoLa muestra estuvo constituida por un total de cuarenta y seis mujeres (edad: 58,2±8,5 años; peso: 72,1±9,6kg; altura: 156,9±6,1cm) diagnosticadas con FM. Los participantes fueron divididos aleatoriamente en tres grupos: ejercicio físico y entrenamiento vibratorio (WBV + EJ; n=15); ejercicio físico sin vibraciones (EJ; n=15) y un grupo control (GC; n=16). Los grupos WBV + EJ y EJ realizaron dos sesiones semanales de ejercicio físico durante 8 semanas. Además, los integrantes de WBV + EJ realizaron 3 sesiones semanales de entrenamiento vibratorio (30Hz, 4mm). Las pruebas de evaluación incluyeron el test de sit and reach (variable principal), la valoración del número de tender points (TP) y una escala analógica visual (VAS) para determinar la rigidez.ResultadosLos resultados derivados del análisis intra e intergrupo no mostraron diferencias significativas en la rigidez o el número de TP, si bien, la prueba de sit and reach mostró una mejora estadísticamente significativa en WBV + EJ (58%; p<0,05). El análisis correlacional mostró una relación inversa (r =-0,55; p<0,05) entre el sit and reach y el número de TP.ConclusiónComo conclusión, podemos indicar que los datos obtenidos en la presente investigación han mostrado los efectos significativos del entrenamiento vibratorio sobre la amplitud de movimiento en mujeres con FM, aunque el número de TP o la rigidez no se vieron afectados en ningún caso.AbstractObjectiveThe main aim of this investigation was twofold: first to evaluate the effects of exercise and whole body vibration training on flexibility in women with fibromyalgia (FM) and determine whether these improvements are related to symptom severity (stiffness and bodily pain).MethodForty-six women (mean±sd, age: 58.2±8.5 years; weight: 72.1±9.6kg; height: 156.9±6.1cm) with FM were randomized into one of three groups: exercise and whole body vibration (WBV) training group (WBV + EX; n=15), exercise training group (EX), and usual-care control group (CG). WBV + EX and EX groups carried out two sessions per week of exercise training for 8 weeks. In addition, WBV + EX group performed 3 vibration-training (30Hz, 4mm) sessions per week. Outcome assessed included sit and reach test (primary outcome), tender points (TP) evaluation, and a visual analog scale (VAS) was used to determine the stiffness level.ResultsResults showed no statistical intra and intergroup differences in stiffness or the number of TP. However, a significant increment in the sit and reach performance was observed in WBV + EX (58%; p<0.05). Moreover, correlation analysis showed an inverse and significant relationship (r=-0.55; p<0.05) between sit and reach and number of TP in WBV+EX group.ConclusionIn conclusion, exercise and WBV seems to be effective on flexibility in women with FM. However, the number of TP and stiffness was not modified after the interventio

Design for FDM of flexible tooling for manufacturing aeronautical components by incremental sheet forming

IOP Conf. Series: Materials Science and Engineering 1193Nowadays, industrial production is required to reduce industrialization times and development costs for new products while maintaining high quality standards. In this context, the development of new flexible manufacturing technologies has gained relevance in the last few years. The use of Fused Deposition Modelling (FDM) additive technique has been recently proposed in different industrial sectors for manufacturing rapid tooling (dies) to be used in conventional sheet metal stamping or stretching processes with a significant decrease in costs and time savings. On the other hand, Incremental Sheet Forming (ISF) technology is characterized by an enhanced formability of the parts thus manufactured as well as for the need of a small number of tooling, reducing costs compared to conventional processes such as hydroforming or stamping. In particular, its simplest variant, Single-Point Incremental Forming (SPIF) requires the use of backing plates, which do not require tight tolerances as their only function is to collaborate in the deformation process acting as a support point. Furthermore, the strength requirements are also not a limitation since the forces involved in SPIF are very small given the local nature of the deformation. In this context, the main objective of this work is the design of a modular tooling system, manufactured using the FDM additive technique, that allows the flexible manufacturing of different aeronautical components by SPIF.Universidad de Sevilla US-1263138Ministerio de Ciencia e Innovación (MICIN). España PGC2018-095508-B-I00Junta de Andalucía P18-RT-386

Multiwavelength studies of MHD waves in the solar chromosphere: An overview of recent results

The chromosphere is a thin layer of the solar atmosphere that bridges the relatively cool photosphere and the intensely heated transition region and corona. Compressible and incompressible waves propagating through the chromosphere can supply significant amounts of energy to the interface region and corona. In recent years an abundance of high-resolution observations from state-of-the-art facilities have provided new and exciting ways of disentangling the characteristics of oscillatory phenomena propagating through the dynamic chromosphere. Coupled with rapid advancements in magnetohydrodynamic wave theory, we are now in an ideal position to thoroughly investigate the role waves play in supplying energy to sustain chromospheric and coronal heating. Here, we review the recent progress made in characterising, categorising and interpreting oscillations manifesting in the solar chromosphere, with an impetus placed on their intrinsic energetics.Comment: 48 pages, 25 figures, accepted into Space Science Review

Ultrasonically enhanced low-temperature drying of apple: Influence on drying kinetics and antioxidant potential

[EN] Low-temperature air drying represents an alternative means to hot air drying of better retaining the sensory, nutritional and functional properties of foods. However, reducing the air temperature to figures below the product s freezing point involves low drying rates, which largely places constraints on any further industrial application. The main aim of this work was to evaluate the feasibility of using power ultrasound to improve the low-temperature drying of apple, considering not only the kinetic effects but also the influence on the antioxidant potential of the dried apple. For that purpose, apple (Malus domestica cv. Granny Smith) cubes (8.8 mm side) were dried (2 m/s and a relative humidity of under 10%) at low temperatures ( 10, 5, 0, 5 and 10 C) with (20.5 kW/m3) and without ultrasound application. The drying kinetics were modeled by considering the diffusion theory, negligible shrinkage and cubic geometry. In the dried apple, total phenolic and flavonoid contents and antioxidant capacity were measured. The application of power ultrasound sped up the drying kinetics at every temperature tested, achieving drying time reductions of up to 77%, which was linked to the improvement in diffusion and convective mass transport. In overall terms, ultrasound application involved a greater degradation of polyphenol and flavonoid contents and a reduction of the antioxidant capacity, which was related to the cell disruption caused by the mechanical stress of acoustic waves.The authors acknowledge the financial support of the Spanish Ministerio de Economia y Competitividad (MINECO), the European Union (FEDER) and the Generalitat Valenciana (from the projects DPI2012-37466-CO3-03, DPI2012-37466-CO3-02, PROMETEO/2010/062 and the FPI fellowship granted to J.V. Santacatalina).Santacatalina Bonet, JV.; Rogríguez, Ó.; Simal, S.; Cárcel Carrión, JA.; Mulet Pons, A.; García Pérez, JV. (2014). Ultrasonically enhanced low-temperature drying of apple: Influence on drying kinetics and antioxidant potential. Journal of Food Engineering. 138:35-44. https://doi.org/10.1016/j.jfoodeng.2014.04.003S354413

Resveratrol Targeting of Carcinogen-Induced Brain Endothelial Cell Inflammation Biomarkers MMP-9 and COX-2 is Sirt1-Independent

The occurrence of a functional relationship between the release of metalloproteinases (MMPs) and the expression of cyclooxygenase (COX)-2, two inducible pro-inflammatory biomarkers with important pro-angiogenic effects, has recently been inferred. While brain endothelial cells play an essential role as structural and functional components of the blood-brain barrier (BBB), increased BBB breakdown is thought to be linked to neuroinflammation. Chemopreventive mechanisms targeting both MMPs and COX-2 however remain poorly investigated. In this study, we evaluated the pharmacological targeting of Sirt1 by the diet-derived and antiinflammatory polyphenol resveratrol. Total RNA, cell lysates, and conditioned culture media from human brain microvascular endothelial cells (HBMEC) were analyzed using qRT-PCR, immunoblotting, and zymography respectively. Tissue scan microarray analysis of grade I–IV brain tumours cDNA revealed increased gene expression of Sirt-1 from grade I–III but surprisingly not in grade IV brain tumours. HBMEC were treated with a combination of resveratrol and phorbol 12-myristate 13-acetate (PMA), a carcinogen known to increase MMP-9 and COX-2 through NF-κB. We found that resveratrol efficiently reversed the PMA-induced MMP-9 secretion and COX-2 expression. Gene silencing of Sirt1, a critical modulator of angiogenesis and putative target of resveratrol, did not lead to significant reversal of MMP-9 and COX-2 inhibition. Decreased resveratrol inhibitory potential of carcinogen-induced IκB phosphorylation in siSirt1-transfected HBMEC was however observed. Our results suggest that resveratrol may prevent BBB disruption during neuroinflammation by inhibiting MMP-9 and COX-2 and act as a pharmacological NF-κB signal transduction inhibitor independent of Sirt1

Surgical treatment for colorectal cancer: Analysis of the influence of an enhanced recovery programme on long-term oncological outcomes-a study protocol for a prospective, multicentre, observational cohort study

Introduction The evidence currently available from enhanced recovery after surgery (ERAS) programmes concerns their benefits in the immediate postoperative period, but there is still very little evidence as to whether their correct implementation benefits patients in the long term. The working hypothesis here is that, due to the lower response to surgical aggression and lower rates of postoperative complications, ERAS protocols can reduce colorectal cancer-related mortality. The main objective of this study is to analyse the impact of an ERAS programme for colorectal cancer on 5-year survival. As secondary objectives, we propose to analyse the weight of each of the predefined items in the oncological results as well as the quality of life. Methods and analysis A multicentre prospective cohort study was conducted in patients older than 18 years of age who are scheduled to undergo surgery for colorectal cancer. The study involved 12 hospitals with an implemented enhanced recovery protocol according to the guidelines published by the Spanish National Health Service. The intervention group includes patients with a minimum implementation level of 70%, and the control group includes those who fail to reach this level. Compliance will be studied using 18 key performance indicators, and the results will be analysed using cancer survival indicators, including overall survival, cancer-specific survival and relapse-free survival. The time to recurrence, perioperative morbidity and mortality, hospital stay and quality of life will also be studied, the latter using the validated EuroQol Five questionnaire. The propensity index method will be used to create comparable treatment and control groups, and a multivariate regression will be used to study each variable. The Kaplan-Meier estimator will be used to estimate survival and the log-rank test to make comparisons. A p value of less than 0.05 (two-tailed) will be considered to be significant. Ethics and dissemination Ethical approval for this study was obtained from the Aragon Ethical Committee (C.P.-C.I. PI20/086) on 4 March 2020. The findings of this study will be submitted to peer-reviewed journals (BMJ Open, JAMA Surgery, Annals of Surgery, British Journal of Surgery). Abstracts will be submitted to relevant national and international meetings. Trial registration number NCT04305314